Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: An apparatus for communicating with mobile receivers for emergency notification and other purposes comprises a localized (low power) transmitter capable of transmitting short bursts of compressed audio or video messages over a selected spatial range. The apparatus further contains a means of measuring the relative speed of the transmitter and receiver(s) and adjusting the transmission accordingly (for example by increasing the output power, shortening the burst length, or increasing the burst repetition rate). In this way, the effective “footprint” of the transmitter and/or the message length is matched to the time the receiver(s) pass within range of the transmitter so that each receiver is able to capture at least one complete burst in the available time. The transmitter may be relatively fixed, for instance on a highway overpass, for communicating with vehicles passing on the highway.

Abstract: A method of selectively and quantitatively removing and concentrating at least one selected ion from a multiple ion solution in which other ions are present is disclosed. The method comprises(a) bringing a complexing agent for the selected ion(s) into contact with the multiple ion solution to remove and concentrate selected ion(s) from the multiple ion solution, wherein the complexing agent is selected from the group of macrocyclic compounds having at least four --A--CH.sub.2 --CH.sub.2 -- groups in which A is selected from O, O--CH.sub.2, S, S--CH.sub.2, N--R and N--R--CH.sub.2 in which R is selected from H, lower alkyl and benzyl, with the macrocyclic compounds further having a hydrocarbon side chain having an end group ##STR1## in which X is selected from the group consisting of lower alkyl, benzyl, phenyl, halogen, O--CH.sub.3, O--C.sub.2 H.sub.

Abstract: The invention has composition of matter and process aspects. The composition of matter aspect relates to the compounds selected from the class consisting of: ##STR1## in which Silica is sand or silica gel. The process aspect involves the use of any of these compounds packed in a column through which a solution of the multiple ions is flowed to complex with the compound and separate a desired selected ion from a multiple ion solution, breaking the complex by flowing a receiving liquid through the column to free the desired ion and recovering the freed desired ion from the receiving liquid.

Abstract: A process of recovering cesium ions from mixtures of ions containing them and other ions, e.g., a solution of nuclear waste materials, which comprises establishing a separate source phase containing such a mixture of ions, establishing a separate recipient phase, establishing a liquid membrane phase in interfacial contact with said source and recipient phases, said membrane phase containing a ligand, preferably a selected calixarene as depicted in the drawing, maintaining said interfacial contact for a period of time long enough to transport by said ligand a substantial portion of the cesium ion from the source phase to the recipient phase, and recovering the cesium ion from the recipient phase. The separation of the source and recipient phases may be by the membrane phase only, e.g., where these aqueous phases are emulsified as dispersed phases in a continuous membrane phase, or may include a physical barrier as well, e.g.