Abstract: A method of operating a telemetry system includes automatically populating a base field of a schema in an event definition using a logging library of the telemetry system for an event of an instrumented application, and automatically populating a conditional field of the schema in the event definition using the logging library in response to a selected condition for the event.

Abstract: Kits and methods for diagnosing risk of developing lung cancers and uses thereof are described. In a first aspect, described herein are lung cancer risk test kits that include reagents for measurement of multiple low VAF (defined as VAF<1%) mutants in a set of lung cancer driver genes; and, instructions therefor.

Abstract: A method of operating a telemetry system includes automatically populating a first set of fields in a schema of an event definition using a logging library of the telemetry system, and receiving the set of fields via a request message in an application protocol.

Abstract: A device for distributing gas near a weld location includes a cap, a funnel, an inlet, and an aperture. The cap includes a sidewall and an annular lip, and defines a reservoir between the sidewall and the annular lip. The annular lip includes a proximal-most edge. The cap defines an opening, and defines a longitudinal axis. The funnel is disposed adjacent a distal end of the cap. The inlet is disposed in mechanical cooperation with the cap. The aperture is disposed through the sidewall of the cap and is in fluid communication with the inlet. The aperture is disposed distally of the proximal-most edge of the annular lip. Gas is configured to flow through the inlet, through the aperture and into the reservoir. The reservoir is configured to allow the gas to uniformly overflow the proximal-most edge of the annular lip and flow distally through the opening defined by the cap.

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract: An electrosurgical instrument includes first and second jaw members each including an outer jaw housing, a tissue-treating plate, and a longitudinally-extending knife channel. The electrosurgical instrument also includes a knife actuator and a knife assembly operably coupled to the knife actuator. The knife assembly includes an elongated tube defining a longitudinal lumen and an elongated shaft having a proximal portion coupled to the knife actuator and a distal portion configured to be received through the longitudinal lumen. The distal portion of the elongated shaft includes an enlarged distal end portion configured to prevent movement of the elongated shaft relative to the elongated tube. The knife assembly also includes a knife blade having a pair of opposing lateral sides and a sharpened distal end configured to cut tissue. The elongated tube is configured to be coupled to one of the pair of opposing lateral sides of the knife blade.

Abstract: Pyrazole carboxamide compounds of Formula I are provided, with various substituents, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk, and for treating cancer and immune disorders such as inflammation mediated by Btk. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract: Pyrazole carboxamide compounds of Formula I are provided, with various substituents, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk, and for treating cancer and immune disorders such as inflammation mediated by Btk. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: A device for distributing gas near a weld location includes a cap, a funnel, an inlet, and an aperture. The cap includes a sidewall and an annular lip, and defines a reservoir between the sidewall and the annular lip. The annular lip includes a proximal-most edge. The cap defines an opening, and defines a longitudinal axis. The funnel is disposed adjacent a distal end of the cap. The inlet is disposed in mechanical cooperation with the cap. The aperture is disposed through the sidewall of the cap and is in fluid communication with the inlet. The aperture is disposed distally of the proximal-most edge of the annular lip. Gas is configured to flow through the inlet, through the aperture and into the reservoir. The reservoir is configured to allow the gas to uniformly overflow the proximal-most edge of the annular lip and flow distally through the opening defined by the cap.

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R1, R2, R3, R4 and R5are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract: Pyrazole carboxamide compounds of Formula I are provided, with various substituents, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk, and for treating cancer and immune disorders such as inflammation mediated by Btk. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: Compounds having the formula I wherein R1, R2, R3, R4, R5, Ra, Rb, Rc, Rd, Re, n, r, s and t are as defined herein and which compounds are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.

Abstract: Compounds having the formula I, or a pharmaceutically acceptable salt thereof, wherein R1, R2, X1, X2, and Ar are as defined herein, are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders using such compounds.

Abstract: 8-Fluorophthalazin-1(2h)-one compounds of Formula I where one or two of X1, X2, and X3 are N, are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: An automated device facilitates the assembly a surgical instrument that includes a knife with a high aspect ratio. The automated device includes a fixture for restraining a subassembly of the surgical instrument that includes the knife. A blade grip on the device is movable relative to the fixture, and is configured to urge the knife into a restrained position in the subassembly suitable for the subsequent assembly of an additional instrument component. A grip actuator is provided to move the blade grip.

Abstract: An automated device facilitates the assembly a surgical instrument that includes a knife with a high aspect ratio. The automated device includes a fixture for restraining a subassembly of the surgical instrument that includes the knife. A blade grip on the device is movable relative to the fixture, and is configured to urge the knife into a restrained position in the subassembly suitable for the subsequent assembly of an additional instrument component. A grip actuator is provided to move the blade grip.

Abstract: An automated device facilitates the assembly a surgical instrument that includes a knife with a high aspect ratio. The automated device includes a fixture for restraining a subassembly of the surgical instrument that includes the knife. A blade grip on the device is movable relative to the fixture, and is configured to urge the knife into a restrained position in the subassembly suitable for the subsequent assembly of an additional instrument component. A grip actuator is provided to move the blade grip.

Abstract: An automated device facilitates the assembly a surgical instrument that includes a knife with a high aspect ratio. The automated device includes a fixture for restraining a subassembly of the surgical instrument that includes the knife. A blade grip on the device is movable relative to the fixture, and is configured to urge the knife into a restrained position in the subassembly suitable for the subsequent assembly of an additional instrument component. A grip actuator is provided to move the blade grip.