Patents by Inventor James J. D. Hsieh

James J. D. Hsieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of Taspase1 protease activity
    Patent number: 7964700
    Abstract: A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the myeloid/lymphoid or mixed-lineage leukemia (i.e., MLL) protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inhibitors of Taspase1. Methods of using the inhibitors of Taspase1 are also described. For example an inhibitor of Taspase1 can be used to treat a cancer, e.g., leukemia, in a subject.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: June 21, 2011
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: James J. D. Hsieh, Stanley J. Korsmeyer, Susan Korsmeyer, legal representative, Emily H. Y. Cheng
  • Taspase1 and Methods of Use
    Publication number: 20080177034
    Abstract: A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the myeloid/lymphoid or mixed-lineage leukemia (i.e., MLL) protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inhibitors of Taspase1. Methods of using the inhibitors of Taspase1 are also described. For example an inhibitor of Taspase1 can be used to treat a cancer, e.g., leukemia, in a subject.
    Type: Application
    Filed: September 6, 2007
    Publication date: July 24, 2008
    Inventors: James J.D. Hsieh, Stanley J. Korsmeyer, Susan Korsmeyer, Emily H. Y. Cheng