Abstract: Techniques are provided for generating sound using a speaker mounted to an enclosure (e.g., speaker cabinet) wherein a gas pressure level (e.g., air pressure level) inside the enclosure is lower than an ambient air pressure level outside the enclosure. The reduced gas pressure level within the enclosure provides an environment with a reduced pressure level at a back side of a speaker cone of the speaker, which enhances a low frequency response for a given speaker size, while also minimizing resonant frequencies and phase cancellation issues which could otherwise occur with conventional speaker systems in which acoustic sound waves are generated at the back side of the speaker cone. A pressure compensation system is utilized counteract a force applied to the front side of the speaker cone as a result of the gas pressure level inside the enclosure being lower than the ambient air pressure level outside the enclosure.

Abstract: Methods for prophylaxis, treatment, and reduction of infection, re-infection, and transmission rates of Coronaviruses and more particularly Coronavirus Disease 2019 (COVID-19) resulting from a SARS-CoV-2 viral infection with the use of a pharmaceutical preparation comprising one or more coated or uncoated digestive enzymes, such as pancreatic enzymes and porcine pancreatic enzymes are described herein.

Abstract: Techniques are provided for generating sound using a speaker mounted to an enclosure (e.g., speaker cabinet) wherein a gas pressure level (e.g., air pressure level) inside the enclosure is lower than an ambient air pressure level outside the enclosure. The reduced gas pressure level within the enclosure provides an environment with a reduced pressure level at a back side of a speaker cone of the speaker, which enhances a low frequency response for a given speaker size, while also minimizing resonant frequencies and phase cancellation issues which could otherwise occur with conventional speaker systems in which acoustic sound waves are generated at the back side of the speaker cone. A pressure compensation system is utilized counteract a force applied to the front side of the speaker cone as a result of the gas pressure level inside the enclosure being lower than the ambient air pressure level outside the enclosure.

Abstract: Methods for prophylaxis, treatment, and reduction of infection, re-infection, and transmission rates of Coronaviruses and more particularly Coronavirus Disease 2019 (COVID-19) resulting from a SARS-CoV-2 viral infection with the use of a pharmaceutical preparation comprising one or more coated or uncoated digestive enzymes, such as pancreatic enzymes and porcine pancreatic enzymes are described herein.

Abstract: Described herein are compositions which include digestive enzymes and which are formulated to reduce one or more symptoms of Celiac disease. Also described herein is a method for treating a subject with Celiac disease using digestive enzymes and their derivatives to alleviate the symptoms of Celiac disease. The method comprises administering to the individual an effective amount of digestive enzymes that are either naturally or recombinantly derived, or their derivatives, in an amount effective to reduce one or more symptoms of Celiac disease.

Abstract: Systems, methods, and apparatus are provided for recording high output power levels of sound at low sound pressure levels. For example, an apparatus comprises an enclosure, a speaker disposed within the enclosure, a microphone disposed within the enclosure, and an evacuation port. The evacuation port is configured to connect to a system that reduces a pressure level within the enclosure to a level that is less than an ambient air pressure level outside the enclosure. The enclosure is sealed or otherwise configured to provide a sealed enclosure, to maintain the reduced air pressure within the enclosure. The speaker can be driven by an amplifier at high output power levels to generate a distorted sound of an amplified electric musical instrument for recording purposes, while the reduced pressure level within the enclosure serves to attenuate the sound pressure level and perceived loudness which emanates from the speaker.

Abstract: Described herein are compositions which include digestive enzymes and which are formulated to reduce one or more symptoms of Celiac Disease. Also described herein is a method for treating a subject with Celiac Disease using digestive enzymes and their derivatives to alleviate the symptoms of Celiac Disease. The method comprises administering to the individual an effective amount of digestive enzymes that are either naturally or recombinantly derived, or their derivatives, in an amount effective to reduce one or more symptoms of Celiac Disease.

Abstract: Compositions and methods for treating or preventing E. coli infections are provided. The compositions can be formulated as pharmaceutical compositions or as disinfectants, sanitizers, detergents or antiseptics, and can be used to eradicate or reduce E. coli populations and thereby treat or prevent infection by E. coli. The compositions include one or more digestive enzymes, e.g., one or more protease, lipases, and amylases. Methods of use of the compositions are also provided.

Abstract: Methods for prophylaxis, treatment, and reduction of infection, re-infection, and transmission rates of Coronaviruses and more particularly Coronavirus Disease 2019 (COVID-19) resulting from a SARS-CoV-2 viral infection with the use of a pharmaceutical preparation comprising one or more coated or uncoated digestive enzymes, such as pancreatic enzymes and porcine pancreatic enzymes are described herein.

Abstract: Techniques are provided for generating sound using a speaker mounted to an enclosure (e.g., speaker cabinet) wherein a gas pressure level (e.g., air pressure level) inside the enclosure is lower than an ambient air pressure level outside the enclosure. The reduced gas pressure level within the enclosure provides an environment with a reduced pressure level at a back side of a speaker cone of the speaker, which enhances a low frequency response for a given speaker size, while also minimizing resonant frequencies and phase cancellation issues which could otherwise occur with conventional speaker systems in which acoustic sound waves are generated at the back side of the speaker cone. A pressure compensation system is utilized counteract a force applied to the front side of the speaker cone as a result of the gas pressure level inside the enclosure being lower than the ambient air pressure level outside the enclosure.

Abstract: Disclosed herein are methods of using coated digestive enzyme preparations and enzyme delivery systems and pharmaceutical compositions comprising the preparations for treatment of subjects having behavioral disorders, neurological disorders or mental health disorders. Disclosed herein are methods of treating core and non-core symptoms of behavioral disorders, neurological disorders or mental health disorders. Also disclosed herein are products for use in methods of treatment and methods of making the same.

Abstract: Systems, methods, and apparatus are provided for recording high output power levels of sound at low sound pressure levels. For example, an apparatus comprises an enclosure, a speaker disposed within the enclosure, a microphone disposed within the enclosure, and an evacuation port. The evacuation port is configured to connect to a system that reduces a pressure level within the enclosure to a level that is less than an ambient air pressure level outside the enclosure. The enclosure is sealed or otherwise configured to provide a sealed enclosure, to maintain the reduced air pressure within the enclosure. The speaker can be driven by an amplifier at high output power levels to generate a distorted sound of an amplified electric musical instrument for recording purposes, while the reduced pressure level within the enclosure serves to attenuate the sound pressure level and perceived loudness which emanates from the speaker.

Abstract: Techniques are provided for generating sound using a speaker mounted to an enclosure (e.g., speaker cabinet) wherein a gas pressure level (e.g., air pressure level) inside the enclosure is lower than an ambient air pressure level outside the enclosure. The reduced gas pressure level within the enclosure provides an environment with a reduced pressure level at a back side of a speaker cone of the speaker, which enhances a low frequency response for a given speaker size, while also minimizing resonant frequencies and phase cancellation issues which could otherwise occur with conventional speaker systems in which acoustic sound waves are generated at the back side of the speaker cone. A pressure compensation system is utilized counteract a force applied to the front side of the speaker cone as a result of the gas pressure level inside the enclosure being lower than the ambient air pressure level outside the enclosure.

Abstract: Compositions and methods for treating or preventing S. aureus infections are provided. The compositions can be formulated as pharmaceutical compositions or as disinfectants, sanitizers, detergents or antiseptics, and can be used to eradicate or reduce S. aureus populations and thereby treat or prevent infection by S. aureus. The compositions include one or more digestive enzymes, for example, one or more protease, lipases, and amylases. Methods of use of the compositions are also provided.

Abstract: This disclosure relates to early diagnosis and assessment tools for Parkinson's disease, movement disorder, neurological disease, and/or chronic pain, designed to drive innovation and to accelerate best Parkinson's disease, movement disorders, neurological disease, and chronic pain research. The present disclosure facilitates improved access to Parkinson's disease, movement disorders, neurological disease, and chronic pain patients along with innovative data capture methods that are designed to leading to improved therapies and assisting in finding a cure for Parkinson's disease, movement disorders, neurological diseases, and/or chronic pain. In addition the present disclosure is broadly applicable as a diagnosis and assessment tool to all movement disorders and many neurological diseases and/or chronic pain.

Abstract: This disclosure relates to early diagnosis and assessment tools for Parkinson's disease, movement disorder, neurological disease, and/or chronic pain, designed to drive innovation and to accelerate best Parkinson's disease, movement disorders, neurological disease, and chronic pain research. The present disclosure facilitates improved access to Parkinson's disease, movement disorders, neurological disease, and chronic pain patients along with innovative data capture methods that are designed to leading to improved therapies and assisting in finding a cure for Parkinson's disease, movement disorders, neurological diseases, and/or chronic pain. In addition the present disclosure is broadly applicable as a diagnosis and assessment tool to all movement disorders and many neurological diseases and/or chronic pain.

Abstract: Systems, methods, and apparatus are provided for recording high output power levels of sound at low sound pressure levels. For example, an apparatus comprises an enclosure, a speaker disposed within the enclosure, a microphone disposed within the enclosure, and an evacuation port. The evacuation port is configured to connect to a system that reduces a pressure level within the enclosure to a level that is less than an ambient air pressure level outside the enclosure. The enclosure is sealed or otherwise configured to provide a sealed enclosure, to maintain the reduced air pressure within the enclosure. The speaker can be driven by an amplifier at high output power levels to generate a distorted sound of an amplified electric musical instrument for recording purposes, while the reduced pressure level within the enclosure serves to attenuate the sound pressure level and perceived loudness which emanates from the speaker.

Abstract: Compositions and methods for treating or preventing S. aureus infections are provided. The compositions can be formulated as pharmaceutical compositions or as disinfectants, sanitizers, detergents or antiseptics, and can be used to eradicate or reduce S. aureus populations and thereby treat or prevent infection by S. aureus. The compositions include one or more digestive enzymes, e.g., one or more protease, lipases, and amylases. Methods of use of the compositions are also provided.

Abstract: Techniques are provided for generating sound using a speaker mounted to an enclosure (e.g., speaker cabinet) wherein a gas pressure level (e.g., air pressure level) inside the enclosure is lower than an ambient air pressure level outside the enclosure. The reduced gas pressure level within the enclosure provides an environment with a reduced pressure level at a back side of a speaker cone of the speaker, which enhances a low frequency response for a given speaker size, while also minimizing resonant frequencies and phase cancellation issues which could otherwise occur with conventional speaker systems in which acoustic sound waves are generated at the back side of the speaker cone. A pressure compensation system is utilized counteract a force applied to the front side of the speaker cone as a result of the gas pressure level inside the enclosure being lower than the ambient air pressure level outside the enclosure.

Abstract: Data compression and decompression methods for compressing and decompressing data based on an actual or expected throughput (bandwidth) of a system. In one embodiment, a controller tracks and monitors the throughput (data storage and retrieval) of a data compression system and generates control signals to enable/disable different compression algorithms when, e.g., a bottleneck occurs so as to increase the throughput and eliminate the bottleneck.