Patents by Inventor James J. Frost

James J. Frost has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts
    Patent number: 8524193
    Abstract: The invention provides lipophilic salts, particularly, lipophilic salts comprising a pharmaceutically acceptable anion and at least one phosphonium or ammonium cation. In certain embodiments, the cation is labeled with one or more radioisotopes. The lipophilic salts of the invention exhibit an affinity for dysfunctional mitochondria, and are useful for the imaging of cardiovascular diseases and disorders. The invention also provides pharmaceutical compositions and methods of using the lipophilic salts.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: September 3, 2013
    Assignee: The Johns Hopkins University
    Inventors: Igal Madar, Hayden T. Ravert, Robert Francis Dannals, Ursula A. Scheffel, James J. Frost
  • Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts
    Patent number: 7112318
    Abstract: The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with 18F for non-invasive assessment of ??m, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: September 26, 2006
    Assignee: The Johns Hopkins University
    Inventors: Igal Madar, Hayden T. Ravert, Robert Francis Dannals, Ursula A. Scheffel, James J. Frost
  • Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts
    Publication number: 20040033197
    Abstract: The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with 18F for non-invasive assessment of &Dgr;&PSgr;m, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT.
    Type: Application
    Filed: February 6, 2003
    Publication date: February 19, 2004
    Applicant: The Johns Hopkins University
    Inventors: Igal Madar, Hayden T. Ravert, Robert Francis Dannals, Ursula A. Scheffel, James J. Frost