Patents by Inventor James J. Holecek

James J. Holecek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemically defined medium for human mesenchymal stem cells
    Patent number: 5908782
    Abstract: A composition and method for maintaining the viability of human mesenchymal precursor cells in a serum-free environment which composition includes (1) a minimum essential medium; (2) serum albumin; (3) an iron source; (4) insulin or an insulin-like growth factor; and (5) at least one amino acid selected from the group consisting of glutamine, arginine and and cysteine, and is free of serum. Also, a composition and method for culture expanding human mesenchymal precursor cells in a serum-free environment. This composition further includes a mitogen, paricularly a serotonergic agonist. The cells are preferably isolated human mesenchymal stem cells.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 1, 1999
    Assignee: Osiris Therapeutics, Inc.
    Inventors: Daniel R. Marshak, James J. Holecek