Patents by Inventor James J. Huang

James J. Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
    Patent number: 5047505
    Abstract: Plasmid pUC8 and DNA coding for hIL-1.beta. are used to construct hybrid plasmids capable of high level expression in E. coli of soluble proteins, including mature hIL-1.beta. and derivatives of mature hIL-1.beta. having amino acid substitutions and insertions at one or all of positions 1 to 4 at the amino terminus. Derivatives of hIL-1.beta. with alterations at the N-terminus have been produced which have either enhanced or decreased bioactivity compared to native monocyte derived hIL-1.beta..
    Type: Grant
    Filed: December 18, 1987
    Date of Patent: September 10, 1991
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventor: James J. Huang