Abstract: Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

Abstract: Novel quinazolinones useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

Abstract: A sorting machine 10 having a lifting and rotating apparatus 11 which includes a rotatable platform 16 upon which a stack of pallets 1 can rest so as to be supported from underneath and a scissor lift 14 for raising and lowering the stack so that the uppermost pallet 1 is moved firstly to an inspection level where it is rotated with the rotatable platform 16 for exposing its top and sides to an operator and then to a transfer level. The machine 10 also has a support device 12 having tynes 17 which moves into an extended position to support and maintain the pallet 1 at the transfer level when the scissor lift 14 is lowered to thereby expose the bottom of the pallet to the operator, and a transfer carriage 13 to engage opposite sides of the pallet 1 and support the pallet 1 from underneath. The pallet 1 is then transported by the transfer carriage 13 to one of a plurality of outfeed stations 25 after the support device 12 is moved into its retracted position.