Patents by Inventor James J. Mencel

James J. Mencel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for making polymorphs of bromfenac sodium and bromfenac sodium formulations
    Patent number: 9914697
    Abstract: Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: March 13, 2018
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh Matharu, Gurijala Venu Reddy, James J. Mencel, Xiaoyong Sun
  • Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs
    Patent number: 9216947
    Abstract: Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: December 22, 2015
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh Matharu, Gurijala Venu Reddy, James J. Mencel, Xiaoyong Sun
  • METHODS FOR MAKING POLYMORPHS OF BROMFENAC SODIUM AND BROMFENAC SODIUM FORMULATIONS
    Publication number: 20150274641
    Abstract: Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.
    Type: Application
    Filed: June 12, 2015
    Publication date: October 1, 2015
    Inventors: Saroop Singh MATHARU, Gurijala Venu REDDY, James J. MENCEL, Xiaoyong Sun
  • Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs
    Patent number: 9061968
    Abstract: Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: June 23, 2015
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh Matharu, Gurijala Venu Reddy, James J. Mencel, Xiaoyong Sun
  • Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs
    Patent number: 9045388
    Abstract: Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: June 2, 2015
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh Matharu, Gurijala Venu Reddy, James J. Mencel, Xiaoyong Sun
  • LOW ABUK OXYCODONE, ITS SALTS AND METHODS OF MAKING SAME
    Publication number: 20140206871
    Abstract: A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8,14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14-hydroxycodeinone and can be readily separated from oxycodone.
    Type: Application
    Filed: March 21, 2014
    Publication date: July 24, 2014
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Erno M Keskeny, James J. Mencel, Jen-Sen Dung
  • Low ABUK oxycodone, its salts and methods of making same
    Patent number: 8703950
    Abstract: A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8,14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14-hydroxycodeinone and can be readily separated from oxycodone.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: April 22, 2014
    Assignee: Johnson Matthey Public Limited Co.
    Inventors: Erno M. Keskeny, James J. Mencel, Jen-Sen Dung
  • POLYMORPHS OF BROMFENAC SODIUM AND METHODS FOR PREPARING BROMFENAC SODIUM POLYMORPHS
    Publication number: 20140018428
    Abstract: Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.
    Type: Application
    Filed: September 13, 2013
    Publication date: January 16, 2014
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh Matharu, Gurijala Venu Reddy, James J. Mencel, Xiaoyong Sun
  • POLYMORPHS OF BROMFENAC SODIUM AND METHODS FOR PREPARING BROMFENAC SODIUM POLYMORPHS
    Publication number: 20140011880
    Abstract: Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.
    Type: Application
    Filed: September 13, 2013
    Publication date: January 9, 2014
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh Matharu, Gurijala Venu Reddy, James J. Mencel, Xiaoyong Sun
  • POLYMORPHS OF BROMFENAC SODIUM AND METHODS FOR PREPARING BROMFENAC SODIUM POLYMORPHS
    Publication number: 20130289120
    Abstract: Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.
    Type: Application
    Filed: June 24, 2013
    Publication date: October 31, 2013
    Inventors: Saroop Singh Matharu, Gurijala Venu Reddy, James J. Mencel, Xiaoyong Sun
  • Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs
    Patent number: 8481780
    Abstract: Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: July 9, 2013
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh Matharu, Gurijala Venu Reddy, James J. Mencel, Xiaoyong Sun
  • POLYMORPHS OF BROMFENAC SODIUM AND METHODS FOR PREPARING BROMFENAC SODIUM POLYMORPHS
    Publication number: 20130023588
    Abstract: Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.
    Type: Application
    Filed: September 25, 2012
    Publication date: January 24, 2013
    Inventors: Saroop Singh Matharu, Gurijala Venu Reddy, James J. Mencel, Xiaoyong Sun
  • Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs
    Patent number: 8299295
    Abstract: Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: October 30, 2012
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh Matharu, Gurijala Venu Reddy, James J. Mencel, Xiaoyong Sun
  • LOW ABUK OXYCODONE, ITS SALTS AND METHODS OF MAKING SAME
    Publication number: 20120259118
    Abstract: A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8,14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14-hydroxycodeinone and can be readily separated from oxycodone.
    Type: Application
    Filed: July 1, 2011
    Publication date: October 11, 2012
    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
    Inventors: Erno M. Keskeny, James J. Mencel, Jen-Sen Dung
  • POLYMORPHS OF BROMFENAC SODIUM AND METHODS FOR PREPARING BROMFENAC SODIUM POLYMORPHS
    Publication number: 20110092596
    Abstract: Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.
    Type: Application
    Filed: September 27, 2010
    Publication date: April 21, 2011
    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
    Inventors: Saroop Singh Matharu, Gurijala Venu Reddy, James J. Mencel, Xiaoyong Sun
  • Method for making analgesics
    Patent number: 7851482
    Abstract: Improved analgesic oxymorphone hydrochloride contains less than 10 ppm of alpha, beta unsaturated ketones and pharmaceutical preparations comprising such oxymorphone hydrochloride. The oxymorphone hydrochloride is produced by reducing a starting material oxymorphone hydrochloride using gaseous hydrogen and under specified acidity, solvent system and temperature conditions. A specific polymorph of oxymorphone hydrochloride may be obtained by hydration.
    Type: Grant
    Filed: October 3, 2007
    Date of Patent: December 14, 2010
    Assignee: Johnson Matthey Public Limited Compnay
    Inventors: Jen-Sen Dung, Erno M. Keskeny, James J. Mencel
  • METHOD FOR MAKING PHARMACEUTICAL COMPOUNDS
    Publication number: 20100125146
    Abstract: A method of making a phenylethylamine of formula B: wherein R2, R3, R4, R5, R6, R?, R? and Rn are each independently selected from hydrogen, alkyl, acyl, aryl, amido, amino acids, sugars and nucleotides. The method includes the reduction of a compound of formula A in the absence of base: wherein R2, R3, R4, R5, R6, R?, R? and Rn are as defined above.
    Type: Application
    Filed: November 19, 2008
    Publication date: May 20, 2010
    Applicant: Johnson Matthey Public Limited Company
    Inventors: James J. Mencel, Paul Fishbein
  • METHOD FOR MAKING ANALGESICS
    Publication number: 20080146601
    Abstract: Improved analgesic oxymorphone hydrochloride contains less than 10 ppm of alpha, beta unsaturated ketones and pharmaceutical preparations comprising such oxymorphone hydrochloride. The oxymorphone hydrochloride is produced by reducing a starting material oxymorphone hydrochloride using gaseous hydrogen and under specified acidity, solvent system and temperature conditions. A specific polymorph of oxymorphone hydrochloride may be obtained by hydration.
    Type: Application
    Filed: October 3, 2007
    Publication date: June 19, 2008
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Jen-Sen Dung, Emo M. Keskeny, James J. Mencel
  • STABLE NON-HYGROSCOPIC CRYSTALLINE FORM OF N-[N-[N-(4-(PIPERIDIN-4-YL)BUTANOYL)-N-ETHYLGLYCYL]ASPARTYL]-L-&bgr;-CYCLOHEXYL ALANINE AMIDE, INTERMEDIATES THEREOF, AND PREPARATION THEREOF AND OF ANTITHROMBOTIC AZACYCLOALKYLALKANOYL PEPTIDES AND PSEUDOPEPTIDES
    Patent number: 6753409
    Abstract: The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-&bgr;-cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula wherein: A, B, Z, E1, E2, G, R, m, n, and p are as defined herein.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: June 22, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Zofia J. Chrzan, James J. Mencel, David Toledo-Velasquez, Vincent Windisch, Rick G. Woodward, Diane C. Salazar, Narasimha M. Vemuri, Anthony J. Gardetto, Matthew R. Powers, Gregory G. Kubiak, Robert C. Liu, Benoit J. Vanasse, James P. Sherbine, Walter Rodriguez, Adam W. Sledeski
  • Process for the preparation of resin-bound cyclic peptides
    Patent number: 6569993
    Abstract: This invention is directed to a process for the solid phase, fragment-based synthesis of resin-bound cyclic peptide analogs of parathyroid hormones and analogs of parathyroid hormone-related proteins, which analogs contain at least one bridge between the side chains of two non-adjacent amino acid residues, and to peptide fragments useful therefor.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: May 27, 2003
    Assignee: Aventis Pharma S.A.
    Inventors: Adam W. Sledeski, James J. Mencel