Patents by Inventor James J. Pestka

James J. Pestka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7250295
    Abstract: The present invention provides transgenic plants cells that express a peptide mimotope of the non-peptide mycotoxin deoxynivalenol. In particular, the peptide mimotope competes with deoxynivalenol for binding to a monoclonal antibody and is antagonistic to the inhibitory effects of deoxynivalenol on in vitro protein synthesis. ransgenic plants expressing the peptide mimotype are resistant to deoxynivalenol.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: July 31, 2007
    Assignee: Board of Trustees of Michigan State University
    Inventors: Lynn Patrick Hart, James J. Pestka, Qiaoping Yuan
  • Publication number: 20030165991
    Abstract: The present invention provides a peptide mimotope of the non-peptide mycotoxin deoxynivalenol. In particular, the peptide mimotope competes with deoxynivalenol for binding to a monoclonal antibody and is antagonistic to the inhibitory effects of deoxynivalenol on in vitro protein synthesis. The present invention also provides a method that uses the peptide mimotope to determine whether corn, grains or mixed feed is contaminated with fungi that produces deoxynivalenol. The present invention further provides transgenic plants resistant to deoxynivalenol.
    Type: Application
    Filed: April 9, 2002
    Publication date: September 4, 2003
    Applicant: Board of Trustees operating Michigan State University
    Inventors: Lynn Patrick Hart, James J. Pestka, Qiaoping Yuan
  • Patent number: 6537762
    Abstract: The present invention provides a peptide mimotope of the non-peptide mycotoxin deoxynivalenol. In particular, the peptide mimotope competes with deoxynivalenol for binding to a monoclonal antibody and is antagonistic to the inhibitory effects of deoxynivalenol on in vitro protein synthesis. The present invention also provides a method that uses the peptide mimotope to determine whether corn, grains or mixed feed is contaminated with fungi that produces deoxynivalenol. The present invention further provides transgenic plants resistant to deoxynivalenol.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: March 25, 2003
    Assignee: Board of Trustees of Michigan State University
    Inventors: Lynn Patrick Hart, James J. Pestka, Qiaoping Yuan
  • Patent number: 4835100
    Abstract: Novel monoclonal antibodies to an aflatoxin B.sub.1 and G.sub.1 in a test kit and used in a method of testing are described. The method for producing the monoclonal antibodies uses repeated administration of aflatoxin B.sub.1 or the related analog compound as a 1-position polypeptide to a murine and production of a hybridoma to generate the novel monoclonal antibodies. The novel antibodies have limited cross-reactivity to aflatoxins B.sub.2, G.sub.2 and M.sub.1. Aflatoxin B.sub.1 or aflatoxin G.sub.1 are detected in foods and the like using the test kit and method.
    Type: Grant
    Filed: October 31, 1986
    Date of Patent: May 30, 1989
    Assignee: Neogen Corporation
    Inventors: Deborah E. Dixon, L. Patrick Hart, James J. Pestka
  • Patent number: 4772551
    Abstract: A method for producing monoclonal antibodies to a trichothecene mycotoxin which are used in a test kit and method of testing are described. The method for producing the monoclonal antibodies uses repeated administration, preferably subcutaneously of a trichothecene polypeptide to a murine and production of a hybridoma to generate the monoclonal antibodies. Trichothecenes are detected in foods and the like using the test kit and method.
    Type: Grant
    Filed: December 26, 1985
    Date of Patent: September 20, 1988
    Assignee: Neogen Corporation
    Inventors: L. Patrick Hart, James J. Pestka, Elie H. Gendloff
  • Patent number: 4610877
    Abstract: The present invention relates to novel immunogens which can be employed in a method for eliminating the offensive odor associated with the preparation of meats derived from uncastrated male pigs. "Boar taint," as the characteristic odor has been termed, can be eliminated, or at least substantially reduced by the administration of novel immunogen compositions which are chemical conjugates formed of certain C.sub.19 .DELTA..sup.16 -steroids and their mixtures with a carrier protein. The immunogens can be administered in conventional forms including a vaccine.
    Type: Grant
    Filed: October 19, 1984
    Date of Patent: September 9, 1986
    Assignee: Research Corporation
    Inventors: Albert M. Pearson, Roger I. Brooks, Maynard G. Hogberg, James J. Pestka, J. Ian Gray