Abstract: A parking enforcement device can be secured to a surface adjacent to the area designated as NO PARKING. The enforcement device can include an elongated hollow body, a window provided to the tubular body, a battery, an internal frame assembly disposed inside of the elongated hollow body, and a camera disposed inside of the elongated hollow body. The internal frame assembly defines a cavity in which the battery is located. A camera support pole extends vertically upwards from the internal frame assembly. The camera is secured to the camera support pole and located vertically along the camera support pole such that the camera views outward through the window. A solar panel can be provided atop the parking enforcement device to recharge the battery.

Abstract: A device for coupling a propulsor to a marine vessel. The device includes a mounting bracket configured for attachment to the marine vessel. A support frame has a carriage and is configured for the propulsor to be coupled thereto, where the carriage is configured to slidably engage with the mounting bracket into a fixed position. A member is manually engageable to prevent the carriage from sliding out of the fixed position. The propulsor is coupled to the marine vessel by sliding the carriage into the fixed position and engaging the member, where the propulsor is operable to propel the marine vessel in water when the carriage is in the fixed position, and where the propulsor is configured for decoupling from the marine vessel by disengaging the member and sliding the carriage out of engagement with the mounting bracket.

Abstract: Small-molecule inhibitors of Botulinum toxin, including BoNTA, BoNTD and BoNTE are provided, as well as methods of using the inhibitors.

Abstract: This disclosure relates to materials and methods for inhibiting Botulinum neurotoxin, and more particularly to materials and methods for inhibiting the zinc endopeptidase of Botulinum neurotoxin serotypes A, D and/or E (BoNTA, BoNTD and/or BoNTE).

Abstract: Substrates of botulinum toxin serotype A (BoNT A), kits comprising the substrates, and methods of using the substrates are disclosed. BoNT A cleaves SNAP-25 and the substrates that are based upon a portion of SNAP-25. Various amino acid modifications to the sequence of the peptide based on SNAP-25 are performed. Fluorescence labels that act as donors and acceptors may be added to the substrate to aid in the study of BoNT A.

Abstract: This disclosure relates to materials and methods for inhibiting Botulinum neurotoxin, and more particularly to materials and methods for inhibiting the zinc endopeptidase of Botulinum neurotoxin serotypes A, D and/or E (BoNTA, BoNTD and/or BoNTE).

Abstract: A bracket for mounting a cable to a surface is presented. The bracket restricts lateral and longitudinal movement of a cable while enabling rotational movement. The bracket may be mounted to a first surface so that the cable may be inserted into a second surface. The bracket generally includes a mounting portion, first and second flanges, and an arm. To reduce longitudinal movement of the cable, the cable is inserted through the first flange and fixedly coupled to a ferrule, which is coupled between the second flange and the notch of the arm. To restrict lateral movement of the cable, a first flange includes a tab that when in a raised position, enables the cable to be inserted through the first flange. After which, the tab is lowered to reduce the size of the aperture. The bracket may also include a cap that is fixedly removable from the cable.

Abstract: Small-molecule inhibitors of Botulinum toxin, including BoNTA, BoNTD and BoNTE are provided, as well as methods of using the inhibitors.

Abstract: A termination system for a cable integrated to control a damper, wherein an end portion of the cable is provided about an opening formed in a ceiling or wall, the system includes: a suspension mount having a base and an opened region, the base has an aperture to receive the cable a retaining bar is secured to the suspension mount such that the ceiling or wall is positioned between the suspension mount and the retaining bar and such that the opened region of the suspension mount is positioned over the opening formed in the ceiling or wall, the retaining bar further including a central opening; and a cap having an inside portion and a peg extending from the inside portion, the cap further having an outer periphery sized larger than the retaining bar and larger than the opening formed in the ceiling or wall, and the central opening of the retaining bar is sized to engage the peg, wherein engagement of the peg with the central opening enables the cap to obscure from visibility the retaining bar, the opening in th

Abstract: Disclosed herein is a pharmacophore model for inhibiting Botulinum neurotoxin A metalloprotease activity which comprises a first plane A, a second plane B, a first hydrophobic moiety C, a second hydrophobic moiety D and a positive ionizable substituent E. The pharmacophore model may further comprise a heteroatom in the first plane A. In some embodiments, the distance between the center of the first plane A and the center of the second plane B is about 6.5 to about 9.5 ?. In some embodiments, the distance between the center of the first hydrophobic moiety C and the center of the second hydrophobic moiety D is about 8.0 to about 16.0 ?. In some embodiments, the distance between the center of the first plane to the center of the first hydrophobic moiety C is about 3.0 to about 5.0 ?. In some embodiments, the distance between the center of the second plane to the center of the second hydrophobic moiety C is about 3.0 to about 5.0 ?.

Abstract: A bracket for mounting a cable to a surface is presented. The bracket restricts lateral and longitudinal movement of a cable while enabling rotational movement. The bracket may be mounted to a first surface so that the cable may be inserted into a second surface. The bracket generally includes a mounting portion, first and second flanges, and an arm. To reduce longitudinal movement of the cable, the cable is inserted through the first flange and fixedly coupled to a ferrule, which is coupled between the second flange and the notch of the arm. To restrict lateral movement of the cable, a first flange includes a tab that when in a raised position, enables the cable to be inserted through the first flange. After which, the tab is lowered to reduce the size of the aperture. The bracket may also include a cap that is fixedly removable from the cable.

Abstract: In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or proteins that can serve as FRET substrates and (2) modified peptides or proteins that can serve as immobilized substrates. In both types a fluorescent molecules is present in the substrate, eliminating the requirement for the addition of a fluorigenic reagent. The assays described can be readily adapted for use in automated or robotic systems.

Abstract: In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or proteins that can serve as FRET substrates and (2) modified peptides or proteins that can serve as immobilized substrates. In both types a fluorescent molecules is present in the substrate, eliminating the requirement for the addition of a fluorigenic reagent. The assays described can be readily adapted for use in automated or robotic systems.

Abstract: In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or proteins that can serve as FRET substrates and (2) modified peptides or proteins that can serve as immobilized substrates. In both types a fluorescent molecules is present in the substrate, eliminating the requirement for the addition of a fluorigenic reagent. The assays described can be readily adapted for use in automated or robotic systems.

Abstract: In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or proteins that can serve as FRET substrates and (2) modified peptides or proteins that can serve as immobilized substrates. In both types a fluorescent molecules is present in the substrate, eliminating the requirement for the addition of a fluorigenic reagent. The assays described can be readily adapted for use in automated or robotic systems.

Abstract: In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or proteins that can serve as FRET substrates and (2) modified peptides or proteins that can serve as immobilized substrates. In both types a fluorescent molecules is present in the substrate, eliminating the requirement for the addition of a fluorigenic reagent. The assays described can be readily adapted for use in automated or robotic systems.

Abstract: This invention is a tool for plunge cutting comprising a motor, a transmission connected to the motor and a blade assembly connected to the transmission, wherein the blades move in an oppositely reciprocating and sliding manner to provide plunge cuts of variable depth with closed ends and a continuous perimeter. The tool of the invention may be held and operated with one hand.

Abstract: A label-based assay is described, through modifications of substrate strure and derivatization of serum albumin, which can be used to determine type A proteolytic activity without separation of products.

Abstract: A package for retaining and displaying a plurality of cylindrical items in separated compartments as formed from a pair of compatibly configured plastic clam shells secured to one another. The plastic clam shells define a front package portion having a plurality of cylindrical item receptacles and a rear package portion having another plurality of cylindrical item receptacles. The front and rear package portions are interconnected to permit predetermined movement of the front and rear package portions relative to one another between a first display position in which the front and rear package portions are disposed in generally superimposed, adjacent relation to one another and a second access position in which the front and rear package portions are substantially displaced from one another to permit ready access to the cylindrical items retained in the item receptacles.