Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: This invention modifies and redesigns a spring-loaded, retractable supply hose mechanisms used to pan out, retract, and store hoses used for gases (e.g., oxygen), treatments, or fluids, specifically this inventor's prior art, the Retractable Oxygen Supply Hose Mechanism, U.S. Pat. No. 6,065,490. This invention incorporates an “Adaptor Cap” or “Removable Cap” to prevent slippage of the Swivel connector, incorporates a “Removable Cap” into the upper disc or flange of the supply-hose reel and/or into the mechanism housing cover that acts as an “anti-rotational” device, and features bearing surfaces to prevent reel slippage. This internal ratchet system better prevents binding and kinking of the patient's supply, thereby facilitating the storage and the quick-controlled release of the desired amount of oxygen supply hose for patient's Medical Oxygen and other gases delivery, therapy, or treatments.

Abstract: This invention modifies and redesigns a spring-loaded, retractable supply hose mechanisms used to pan out, retract, and store hoses used for gases (e.g., oxygen), treatments, or fluids, specifically this inventor's prior art, the Retractable Oxygen Supply Hose Mechanism, U.S. Pat. No. 6,065,490. This invention incorporates an “Adaptor Cap” or “Removable Cap” to prevent slippage of the Swivel connector, incorporates a “Removable Cap” into the upper disc or flange of the supply-hose reel and/or into the mechanism housing cover that acts as an “anti-rotational” device, and features bearing surfaces to prevent reel slippage. This internal ratchet system better prevents binding and kinking of the patient's supply, thereby facilitating the storage and the quick-controlled release of the desired amount of oxygen supply hose for patient's Medical Oxygen and other gases delivery, therapy, or treatments.

Abstract: This invention modifies and redesigns a spring-loaded, retractable supply hose mechanisms used to pan out, retract, and store hoses used for gases (e.g., oxygen), treatments, or fluids, specifically this inventor's prior art, the Retractable Oxygen Supply Hose Mechanism, U.S. Pat. No. 6,065,490. This invention incorporates an “Adaptor Cap” or “Removable Cap” to prevent slippage of the Swivel connector, incorporates a “Removable Cap” into the upper disc or flange of the supply-hose reel and/or into the mechanism housing cover that acts as an “anti-rotational” device, and features bearing surfaces to prevent reel slippage. This internal ratchet system better prevents binding and kinking of the patient's supply, thereby facilitating the storage and the quick-controlled release of the desired amount of oxygen supply hose for patient's Medical Oxygen and other gases delivery, therapy, or treatments.

Abstract: A method and apparatus for modeling an object in software are disclosed. The method includes generating a three-dimensional geometry of the object from a plurality of points obtained from a plurality of images of the object, the images having been acquired from a plurality of perspectives; and generating a three-dimensional model from the three-dimensional geometry for integration into an object recognition system. The apparatus may be a program storage medium encoded with instructions that, when executed by a computer, perform such a method or a computer programmed to perform such a method.

Abstract: The compounds of the formula ##STR1## in which one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen, C.sub.1-8 -alkyl, C.sub.3-6 -cycloalkyl, phenyl optionally substituted by halogeno, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy and/or trifluoromethyl, or C.sub.7-10 -phenylalkyl optionally substituted in the phenyl moiety by halogeno, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy and/or trifluormethyl, and the other two are hydrogen, or salts thereof.These compounds have valuable pharmaceutical properties.

Abstract: The compounds of the formula ##STR1## in which one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen, C.sub.1 -.sub.8 -alkyl, C.sub.3 -.sub.6 -cycloalkyl, phenyl optionally substituted by halogeno, C.sub.1 -.sub.4 -alkyl, C.sub.1 -.sub.4 -alkoxy and/or trifluoromethyl, or C.sub.7 -.sub.10 -phenylalkyl optionally substituted in the phenyl moiety by halogeno, C.sub.1 -.sub.4 -alkyl, C.sub.1 -.sub.4 -alkoxy and/or trifluormethyl, and the other two are hydrogen, or salts thereof.These compounds have valuable pharmaceutical properties.

Abstract: The compounds of the formula ##STR1## in which one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen, C.sub.1-8 -alkyl, C.sub.3-6 -cycloalkyl, phenyl optionally substituted by halogeno, C.sub. 1-4 -alkyl, C.sub. -4 -alkoxy and/or trifluoromethyl, or C.sub.7-10 -phenylalkyl optionally substituted in the phenyl moiety by halogeno, C.sub.1-4 -alkyl C.sub.1-4 -alkoxy and/or trifluormethyl, and the other two are hydrogen, or salts thereof.These compounds have valuable pharmaceutical properties.

Abstract: The compounds of the formula ##STR1## in which one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen, C.sub.1 -.sub.8 -alkyl, C.sub.3 -.sub.6 -cycloalkyl, phenyl optionally substituted by halogeno, C.sub.1 -.sub.4 -alkyl, C.sub.1 -.sub.4 -alkoxy and/or trifluoromethyl, or C.sub.7 -.sub.10 -phenylalkyl optionally substituted in the phenyl moiety by halogeno, C.sub.1 -.sub.4 -alkyl, C.sub.1 -.sub.4 -alkoxy and/or trifluoromethyl, and the other two are hydrogen, or salts thereof.These compounds have valuable pharmaceutical properties.

Abstract: The compounds of the formula ##STR1## in which one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen, C.sub.1-8 -alkyl, C.sub.3-6 -cycloalkyl, phenyl optionally substituted by halogeno, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy and/or trifluoromethyl, or C.sub.7-10 -phenylalkyl optionally substituted in the phenyl moiety by halogeno, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy and/or trifluormethyl, and the other two are hydrogen, or salts thereof.These compounds have valuable pharmaceutical properties.

Abstract: New anticorrosive compositions comprise:(A) an applicational medium selected from (a) surface coatings and (b) wholly or partly aqueous non-coating media,(B) as corrosion inhibitor, an effective corrosion-inhibiting amount of at least one aliphatic or cycloaliphatic mono-, di-, tri- or tetra-carboxylic acid ester or anhydride which is substituted in the aliphatic or cycloaliphatic residue by one or more groups having the formula ##STR1## in which X is oxygen, sulphur or NH; and each R, independently, is hydrogen, alkyl, haloalkyl, alkoxy, alkylthio, alkylsulphonyl, cycloalkyl, phenyl, alkylphenyl, phenylalkyl, halogen, cyano, nitro, hydroxy, --COOH, --COOalkyl or a primary-, secondary- or tertiary amino- or carbamoyl group; or a non-toxic base addition salts of those components (B) which contain free carboxyl group.

Abstract: The compounds of the formula ##STR1## in which one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen, C.sub.1-8 -alkyl, C.sub.3-6 -cycloalkyl, phenyl optionally substituted by halogeno, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy and/or trifluoromethyl, or C.sub.7-10 -phenylalkyl optionally substituted in the phenyl moiety by halogeno, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy and/or trifluormethyl, and the other two are hydrogen, or salts thereof.These compounds have valuable pharmaceutical properties.

Abstract: A corrosion-inhibiting coating composition containing(a) a film-former and(b) as the corrosion inhibitor, an effective amount of an aliphatic or cycloaliphatic mono-, di-, tri- or tetra- carboxylic acid which is substituted in its aliphatic or cycloaliphatic radical by at least one group of the formula I ##STR1## in which X is oxygen, sulfur or NH and each R independently of the others is hydrogen, alkyl, halogenoalkyl, alkoxy, alkylthio, alkylsulfonyl, cycloalkyl, phenyl, alkylphenyl, phenylalkyl, halogen, --CN, --NO.sub.2, --COOH, --COOalkyl, --OH or a primary, secondary or tertiary amino or carbamoyl group, R not being --NH.sub.2 in the case of a monocarboxylic acid in which X is sulfur, and also base addition salts of these compounds are useful as corrosion inhibitors.