Abstract: Provided herein are methods of delivering a low viscosity fluid to a targeted sub-region of a subject's nasal cavity via delivery as a continuous liquid stream.

Abstract: The present disclosure describes devices for intranasal drug delivery to targeted regions and sub-regions of a nasal cavity of a subject, including the turbinates. The devices may have a housing with a dispensing element, and a positioning or trigger element coupled to the housing that positions the dispensing element within the nasal channel and limits its depth of insertion. The dispensing element may comprise a side opening for dispensing a composition. Devices of the present disclosure may provide a convenient and effective way to deliver compositions intranasally to the targeted regions and subregions while limiting off-target delivery.

Abstract: A computing system can obtain, through one or more sensor systems onboard an autonomous vehicle, a motion input, a surface element registration input representing one or more tracked surface elements, and a lane alignment input representing one or more lane boundaries. The computing system can provide the motion input, the surface element registration input, and the lane alignment input to a pose estimation system including a localization filter. The pose estimation system can generate one or more pose states of the autonomous vehicle, including a local pose and a global pose. The computing system can determine a motion plan for the autonomous vehicle based on the one or more pose states.

Abstract: The present disclosure describes devices for intranasal delivery. The devices may have a housing with a dispensing element, and a positioning or trigger element coupled to the housing that engages a columella region of the subject to position the dispensing element within the nasal channel and limit its depth of insertion. The devices can also include two insertable portions, each for insertion into a nasal channel of the subject, and an actuator that delivers the composition from either or both of the insertable portions. The devices can be transitioned from a first configuration to a second configuration. Devices of the present disclosure may provide a convenient and effective way to deliver compositions intranasally and to accomplish lateralized delivery to targeted regions of the brain.

Abstract: The present disclosure describes devices for intranasal delivery. The devices may have a housing with a dispensing element, and a positioning or trigger element coupled to the housing that engages a columella region of the subject to position the dispensing element within the nasal channel and limit its depth of insertion. The devices can also include two insertable portions, each for insertion into a nasal channel of the subject, and an actuator that delivers the composition from either or both of the insertable portions. The devices can be transitioned from a first configuration to a second configuration. Devices of the present disclosure may provide a convenient and effective way to deliver compositions intranasally and to accomplish lateralized delivery to targeted regions of the brain.

Abstract: A computing system can obtain, through one or more sensor systems onboard an autonomous vehicle, a motion input, a surface element registration input representing one or more tracked surface elements, and a lane alignment input representing one or more lane boundaries. The computing system can provide the motion input, the surface element registration input, and the lane alignment input to a pose estimation system including a localization filter. The pose estimation system can generate one or more pose states of the autonomous vehicle, including a local pose and a global pose. The computing system can determine a motion plan for the autonomous vehicle based on the one or more pose states.

Abstract: An automated dental drill includes a dental drill housing that includes a mouthpiece housing section and a one or more degrees of freedom drive housing section; an end effector drive support having a shaft section that is at least partially positioned in the mouthpiece housing section, and an end effector for the cutting of a native tooth or dental appliance to a desired tolerance. The end effector is positioned on the end effector drive support. The automated dental drill also includes a power source that drives the end effector and is coupled to the end effector and a one or more degrees of freedom drive assembly to direct the end effector along one or more degrees of freedom relative to the mouthpiece housing section.

Abstract: The present disclosure describes devices for intranasal delivery. The devices may have a housing with a dispensing element, and a positioning or trigger element coupled to the housing that engages a columella region of the subject to position the dispensing element within the nasal channel and limit its depth of insertion. The devices can also include two insertable portions, each for insertion into a nasal channel of the subject, and an actuator that delivers the composition from either or both of the insertable portions. The devices can be transitioned from a first configuration to a second configuration. Devices of the present disclosure may provide a convenient and effective way to deliver compositions intranasally and to accomplish lateralized delivery to targeted regions of the brain.

Abstract: Provided herein are methods of delivering a low viscosity fluid to a targeted sub-region of a subject's nasal cavity via delivery as a continuous liquid stream.

Abstract: The present disclosure describes formulations, methods, and devices for intranasal delivery to a subject. The formulations may form two fluids which are immiscible at intranasal environmental conditions, such that when a formulation is delivered to a nasal cavity the two fluids separate with the more dense of the fluids settling below the less dense of the two fluids. One or more of the two fluids may concentrate a therapeutic agent or sampling fluid against a selected portion of the nasal cavity and the more dense of the two fluids can increase retention time of the formulation within the nasal cavity. Devices of the present disclosure may provide a convenient and effective way to deliver dual-density formulations intranasally.

Abstract: An automated dental drill includes an end effector, including a dental tool for disposition at least partially in a patient's mouth and to perform an operation on a tooth. A tooth clamp releasably rigidly attaches to at least one tooth. A drive assembly is controlled by a processor and positions the end effector with a first at least three degrees of freedom, relative to the tooth clamp. The drive assembly remains outside the patient's mouth. A clamp connector connects the tooth clamp to the drive assembly. With the tooth clamp coupled to the drive assembly and the tooth clamp attached to the at least one tooth, position and orientation of the drive assembly remain fixed, relative to the at least one tooth. A passive cantilever arm, mechanically coupled between a support structure and the drive assembly, has a second at least three degrees of freedom and supports the drive assembly.

Abstract: A localization system can obtain a LIDAR observation oriented relative to a vehicle frame, the vehicle frame oriented with respect to a pose of a vehicle; access a local environment map descriptive of the environment of the vehicle, wherein the local environment map is oriented relative to a keyframe at a given time, the local environment map including a plurality of surfels and generated in real-time during a current operational instance of the vehicle based on one or more prior LIDAR observations captured during the current operational instance of the vehicle; determine a transform between the vehicle frame and the keyframe by aligning the LIDAR observation to the local environment map based on a similarity between the LIDAR observation and the local environment map; and determine an updated pose of the vehicle based on the transform and the pose of the vehicle in the vehicle frame at the given.

Abstract: The present disclosure describes devices for intranasal delivery. The devices may have a housing with a dispensing element, and a positioning or trigger element coupled to the housing that engages a columella region of the subject to position the dispensing element within the nasal channel and limit its depth of insertion. The devices can also include two insertable portions, each for insertion into a nasal channel of the subject, and an actuator that delivers the composition from either or both of the insertable portions. The devices can be transitioned from a first configuration to a second configuration. Devices of the present disclosure may provide a convenient and effective way to deliver compositions intranasally and to accomplish lateralized delivery to targeted regions of the brain.

Abstract: Provided herein are methods of delivering a low viscosity fluid to a targeted sub-region of a subject's nasal cavity via delivery as a continuous liquid stream.

Abstract: The present disclosure describes devices for intranasal delivery. The devices may have a housing with a dispensing element, and a positioning or trigger element coupled to the housing that engages a columella region of the subject to position the dispensing element within the nasal channel and limit its depth of insertion. The devices can also include two insertable portions, each for insertion into a nasal channel of the subject, and an actuator that delivers the composition from either or both of the insertable portions. The devices can be transitioned from a first configuration to a second configuration. Devices of the present disclosure may provide a convenient and effective way to deliver compositions intranasally and to accomplish lateralized delivery to targeted regions of the brain.

Abstract: A set of commands for each of a plurality of actuators to alter an aircraft's state responsive to one or more inputs is produced. The set of commands is provided to fewer than all actuators comprising the plurality of actuators.

Abstract: The present disclosure relates a device that includes a rotary union body. Included with the rotary union body is a circumferential air channel, a seal channel, and an intake air channel. The intake air channel is connected to the circumferential air channel. Also disclosed is a hub assembly system that includes a hub and a rotary union body. Included with the rotary union body is a circumferential air channel, a seal channel and an intake air channel. Here the intake air channel is connected to the circumferential air channel.

Abstract: A computing system can obtain, through one or more sensor systems onboard an autonomous vehicle, a motion input, a surface element registration input representing one or more tracked surface elements, and a lane alignment input representing one or more lane boundaries. The computing system can provide the motion input, the surface element registration input, and the lane alignment input to a pose estimation system including a localization filter. The pose estimation system can generate one or more pose states of the autonomous vehicle, including a local pose and a global pose. The computing system can determine a motion plan for the autonomous vehicle based on the one or more pose states.

Abstract: A set of commands for each of a plurality of actuators to alter an aircraft's state responsive to one or more inputs is produced. The set of commands is provided to fewer than all actuators comprising the plurality of actuators.