Abstract: An apparatus includes an intracardiac tissue engagement sensor configured to sense engagement with a valve leaflet of a heart valve. The intracardiac tissue engagement sensor includes a pair of outer electrodes configured to generate an electric field, and an inner electrode disposed between the outer electrodes. The inner electrode is configured to measure a modified voltage of the electric field based on a distance to the valve leaflet that is positioned proximate to the first inner electrode.

Abstract: An apparatus includes an intracardiac tissue engagement sensor configured to sense engagement with a valve leaflet of a heart valve. The intracardiac tissue engagement sensor includes a first jaw and a second jaw configured for movement relative to one another, where the first jaw and the second jaw are configured to receive a valve leaflet in a space between the first jaw and the second jaw. The intracardiac tissue engagement sensor also includes an emitter coupled to the first jaw, where the emitter is configured to emit energy in an unmodified state, and a receiver coupled to the second jaw. The receiver is configured to receive the energy in a modified state, or not receive the energy, based on interaction with the valve leaflet that is positioned between the emitter and the receiver.

Abstract: Intracardiac devices (e.g., guidewires, catheters, sheaths) with multiple sensors for use in cardiac valve replacement, structural heart procedures, and other medical procedures are provided. The multiple sensors allow for measurements to be made at multiple locations (e.g., on both sides of a heart valve) without having to move the intracardiac device as well as facilitate tracking of the intracardiac device within the anatomy of the patient. In some aspects, the intracardiac devices include one or more electrodes for pacing a heartbeat of the patient, including while obtaining measurements (e.g., pressure measurements) with the multiple sensors. Associated systems and methods are also provided.

Abstract: A simulated environment includes a motion control system. The motion control system may comprise a suspension structure, a housing slidably engaged to the suspension structure such that the suspension controller translates in a planar manner relative to the suspension structure. A rotary component may be rotatably attached to the housing. A plurality of winches may be attached to the rotary component, the plurality of winches having cables to allow longitudinal movement of the cables parallel to a force of gravity.

Abstract: A simulated environment includes a motion control system. The motion control system comprises a suspension structure, a housing slidably engaged to the suspension structure such that the suspension controller translates in a planar manner relative to the suspension structure. A rotary component is rotatably attached to the housing. A plurality of winches are attached to the rotary component, the plurality of winches having cables to allow longitudinal movement of the cables parallel to a force of gravity.

Abstract: One variation of a method for delivering a digital medicine experience to a user includes: loading the digital medicine experience at a sensory immersion vessel; calculating a target value of a bioindicator of the physiological state of the user, the target value of the bioindicator corresponding to a target physiological state of the user; at an initial time, rendering sensory representations of a set of elements in a multi-sensory virtual environment within the sensory immersion vessel at an initial progression rate; at a time during the digital medicine experience, succeeding the initial time, measuring a value of the bioindicator; calculating a progression rate through the digital medicine experience based on a difference between the value of the bioindicator and the target value of the bioindicator; and at a second time succeeding the time, rendering sensory representations of the set of elements in the multi-sensory virtual environment at the progression rate.

Abstract: One variation of a method for delivering a digital medicine experience to a user includes: loading the digital medicine experience at a sensory immersion vessel; calculating a target value of a bioindicator of the physiological state of the user, the target value of the bioindicator corresponding to a target physiological state of the user; at an initial time, rendering sensory representations of a set of elements in a multi-sensory virtual environment within the sensory immersion vessel at an initial progression rate; at a time during the digital medicine experience, succeeding the initial time, measuring a value of the bioindicator; calculating a progression rate through the digital medicine experience based on a difference between the value of the bioindicator and the target value of the bioindicator; and at a second time succeeding the time, rendering sensory representations of the set of elements in the multi-sensory virtual environment at the progression rate.

Abstract: Systems and methods for integrating data related to aircraft operations such as data from flight logs, flight tracker, maintenance, connectivity, router into modules, for a specific aircraft that can be communicated to and displayed on a single device display in real-time. Systems and methods for integrating data related to aircraft operations into modules, that is both aircraft-specific (engine data, take-off and landing times) and personnel specific (i.e. crew scheduling, passenger manifestos), that includes a web-based interface which incorporates multiple data fields, and can display and communicate on devices, including but not limited to desktop computers, portable devices, such as smart phones, tablets and laptops.

Abstract: In example implementations, an apparatus is provided. The apparatus includes a plurality of power outputs, a logic controller and a single switch. Each one of the plurality of power outputs is communicatively coupled to a respective current/power sensor. The logic controller is communicatively coupled to the respective current/power sensor of each one of the plurality of power outputs. The single switch is communicatively coupled to the logic controller and the respective current/power sensor of each one of the plurality of power outputs. Power to each one of the plurality of power outputs is controlled by the logic controller via the single switch.

Abstract: A system for determining a goodness of a deep learning model comprises a memory coupled with a processor. The processor accesses a first set of vectors representative of images of a biological assay. The vectors of the first set of vectors are outputs of a first deep learning model. The processor creates a first distribution of a first plurality of pairwise comparisons of vectors, of the first set of vectors, which were generated from image pairs with similar cell perturbations. The processor creates a second distribution of a second plurality of pairwise comparisons of vectors, of the first set of vectors, which were generated from image pairs with dissimilar cell perturbations. The processor determines a difference between the first distribution and the second distribution and uses the difference to make a determination of goodness of the deep learning model as applied to the biological assay.

Abstract: A system for selecting CRISPR guides for knocking out one or more target genes in a target cell from a multiplicity of candidate guides comprises a memory and a processor. The processor determines whether the candidate guide meets a plurality of thresholds. The thresholds are associated with: a transcript support level; targeting a consensus sequence of a target gene; which exon of the target gene is targeted; targeting of a primary transcript, targeting of a common isoform; a precomputed prediction of editing outcomes; mapping to an expressed sequence; fraction of gene expression attributable to targeted transcripts; a common SNP overlap threshold; which exon of the target gene is targeted; overlap of a selected guide; predicted frameshift percentage; maximum and minimum GC content; off target score; where a coding sequence is targeted. In response to meeting the thresholds, the processor selects the candidate guide as a selected CRISPR guide.

Abstract: The present disclosure provides CRISPC-Cas systems for the creating mutated genes within cells within wells of an addressable well plate.

Abstract: A simulated environment includes a motion control system. The motion control system comprises a suspension structure, a housing slidably engaged to the suspension structure such that the suspension controller translates in a planar manner relative to the suspension structure. A rotary component is rotatably attached to the housing. A plurality of winches are attached to the rotary component, the plurality of winches having cables to allow longitudinal movement of the cables parallel to a force of gravity.

Abstract: The flow of teams of one or more players is controlled through different geographical areas of a mixed virtual reality and physical experience that takes place on an attraction stage. The geographical areas may include rooms, compartments, or other geographical areas through which a team may progress. Within each geographical area, a team may engage in an experience and accomplish one or more checkpoints. Based on the time to achieve each checkpoint, the experience may be shortened or lengthened, either within the particular geographical area or the experience as a whole, to control the flow of the particular team through the series of geographical areas.

Abstract: In part, the disclosure related to systems and methods of merging a simulation experience with physical objects and sensory stimuli generated outside of the simulation in a controlled physical environment to enhance the simulated experience.

Abstract: The flow of teams of one or more players is controlled through different geographical areas of a mixed virtual reality and physical experience that takes place on an attraction stage. The geographical areas may include rooms, compartments, or other geographical areas through which a team may progress. Within each geographical area, a team may engage in an experience and accomplish one or more checkpoints. Based on the time to achieve each checkpoint, the experience may be shortened or lengthened, either within the particular geographical area or the experience as a whole, to control the flow of the particular team through the series of geographical areas.

Abstract: In example implementations, an apparatus is provided. The apparatus includes a plurality of power outputs, a logic controller and a single switch. Each one of the plurality of power outputs is communicatively coupled to a respective current/power sensor. The logic controller is communicatively coupled to the respective current/power sensor of each one of the plurality of power outputs. The single switch is communicatively coupled to the logic controller and the respective current/power sensor of each one of the plurality of power outputs. Power to each one of the plurality of power outputs is controlled by the logic controller via the single switch.

Abstract: One variation of a method for delivering a digital medicine experience to a user includes: loading the digital medicine experience at a sensory immersion vessel; calculating a target value of a bioindicator of the physiological state of the user, the target value of the bioindicator corresponding to a target physiological state of the user; at an initial time, rendering sensory representations of a set of elements in a multi-sensory virtual environment within the sensory immersion vessel at an initial progression rate; at a time during the digital medicine experience, succeeding the initial time, measuring a value of the bioindicator; calculating a progression rate through the digital medicine experience based on a difference between the value of the bioindicator and the target value of the bioindicator; and at a second time succeeding the time, rendering sensory representations of the set of elements in the multi-sensory virtual environment at the progression rate.

Abstract: Methods, systems and devices for real position reports between an aircraft and a terrestrial network using SwiftBroadband and a set of calculation instructions which identifies the specific aircraft and calculates multiple variables including, but not limited to, Speed, Heading, Departure Airport, and Arrival Airport. Once all variables have been calculated the system tracks the aircraft status on a map for multiple platforms. The position tracking system generates position reports that can be integrated into combined mapping system of other source data to give the most accurate position data possible.

Abstract: Systems and methods for integrating data related to aircraft operations such as data from flight logs, flight tracker, maintenance, connectivity, router into modules, for a specific aircraft that can be communicated to and displayed on a single device display in real-time. Systems and methods for integrating data related to aircraft operations into modules, that is both aircraft-specific (engine data, take-off and landing times) and personnel specific (i.e. crew scheduling, passenger manifestos), that includes a web-based interface which incorporates multiple data fields, and can display and communicate on devices, including but not limited to desktop computers, portable devices, such as smart phones, tablets and laptops.