Patents by Inventor James Jiu

James Jiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microbial process for 9.alpha.-hydroxylation of steroids
    Patent number: 4397947
    Abstract: Valuable 9.alpha.-hydroxy steroids are prepared via microbial enzymatic oxidation (MEO) by conventional fermentation means, without the need for a .DELTA..sup.1 dehydrogenation inhibitor, utilizing novel microorganism Nocardia canicruria ATCC 31548. Also disclosed is a novel method using any .DELTA..sup.1 dehydrogenase producing organism and a novel bio-reactor technique means for preparing said steroids.
    Type: Grant
    Filed: June 12, 1981
    Date of Patent: August 9, 1983
    Assignee: G. D. Searle & Co.
    Inventors: William J. Marsheck, James Jiu, Ping T. Wang
  • 2-(2-Amino-4-chlorophenoxy)benzyl alcohol and diacetate derivative
    Patent number: 4086268
    Abstract: 8-Chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine is transformed by various microorganisms into compounds having useful pharmacological properties or useful as intermediates in the synthesis of various pharmaceutical compounds. Among the microorganisms useful for this purpose are Trichoderma lignorum NRRL 8138, Hormodendrum sp. NRRL 8133, Cladosporium lignicolum NRRL 8131, Hormodendrum cladosporioides NRRL 8132, Pullularia pullulans NRRL 8137, Penicillium sp. NRRL 8136, Mucor sp. NRRL 8135, Chaetomium sp. NRRL 8130, and Hormodendrum sp. NRRL 8134.
    Type: Grant
    Filed: September 20, 1976
    Date of Patent: April 25, 1978
    Assignee: G. D. Searle & Co.
    Inventors: James Jiu, Seth S. Mizuba
  • Process of preparing 3-oxo-pregna-4,17(20)-dien-21-carboxylic acid and esters with mycobacterium
    Patent number: 4032408
    Abstract: The present invention is concerned with the preparation of 3-oxo-pregna-4,17(20)-dien-21-carboxylic acid and esters thereof by the microbial degradation of fucosterol, cholesterol, stigmasterol, campesterol or sitosterol with Mycobacterium sp. NRRL B-8054. The compounds of the present invention are useful antispasmodic agents and are also active against influenza virus.
    Type: Grant
    Filed: August 4, 1976
    Date of Patent: June 28, 1977
    Assignee: G. D. Searle & Co.
    Inventors: James Jiu, William J. Marsheck
  • Microbial transformation of 8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine
    Patent number: 3997401
    Abstract: 8-Chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine is transformed by various microorganisms into compounds having useful pharmacological properties or useful as intermediates in the synthesis of various pharmaceutical compounds. Among the microorganisms useful for this purpose are Trichoderma lignorum NRRL 8138, Hormodendrum sp. NRRL 8133, Cladosporium lignicolum NRRL 8131, Hormodendrum cladosporioides NRRL 8132, Pullularia pullulans NRRL 8137, Penicillium sp. NRRL 8136, Mucor sp. NRRL 8135, Chaetomium sp. NRRL 8130, and Hormodendrum sp. NRRL 8134.
    Type: Grant
    Filed: December 8, 1975
    Date of Patent: December 14, 1976
    Assignee: G. D. Searle & Co.
    Inventors: James Jiu, Seth S. Mizuba
  • 3-Oxo-pregna-4,17(20)-dien-20-carboxylic acid and esters
    Patent number: 3994933
    Abstract: The present invention is concerned with the preparation of 3-oxo-pregna-4,17(20)-dien-21-carboxylic acid and esters thereof by the microbial degradation of fucosterol, cholesterol, stigmasterol, campesterol or sitosterol with Mycobacterium sp. NRRL B-8054. The compounds of the present invention are useful antispasmodic agents and are also active against influenza virus.
    Type: Grant
    Filed: April 30, 1975
    Date of Patent: November 30, 1976
    Assignee: G. D. Searle & Co.
    Inventors: James Jiu, William J. Marsheck