Abstract: The present invention relates to novel Chimeric Antigen Receptor (CAR) constructs, including CAR-T constructs, compositions for use with said constructs, and methods of treating patients with cancer and autoimmune diseases.

Abstract: Systems and methods relating to identifying raw materials and predicting gas production based on the identified raw materials. Machine learning models are used to identify (through pattern matching or curve fitting) raw materials. Once the raw materials are identified, expected gases and their quantities produced through fermentation are determined using another machine learning model. The predicted gases and amounts are then sent to a user.

Abstract: Methods are provided for the treatment or prevention of metastasis by the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with a cell impermeable ENPP1 inhibitor to treat or prevent metastasis. Aspects of the methods include administering to a subject in need thereof a therapeutically effective amount of an immune checkpoint inhibitor, a chemotherapeutic agent, and/or radiation treatment, in combination with a therapeutically effective amount of a cell impermeable ENPP1 inhibitor to treat or prevent metastasis.

Abstract: Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with a cell impermeable ENPP1 inhibitor to inhibit cGAMP hydrolysis activity of ENPP1. Aspects of the methods include administering to a subject in need thereof a therapeutically effective amount of a CAR expressing immune cell in combination with a therapeutically effective amount of a cell impermeable ENPP1 inhibitor to inhibit the hydrolysis of cGAMP.

Abstract: An apparatus for and a method of analyzing a sample. A laser section may include a laser arranged to direct a laser beam in a first direction towards the sample. The laser beam ablating and ionizing at least a portion of the sample to generate ions. An ion source section may include a sample holder for holding the sample. At least one component is arranged to apply an electric field for extracting at least a portion of the ions to form an ion beam traveling in a second direction. A time-of-flight section may include a detector arranged to receive the ion beam.

Abstract: A polishing composition includes an anionic abrasive, a pH adjuster a low-k removal rate inhibitor, a ruthenium removal rate enhancer, and water. A method of polishing a substrate includes the steps of: applying the polishing composition described herein to a surface of a substrate, wherein the surface comprises ruthenium or a hard mask material; and bringing a pad into contact with the surface of the substrate and moving the pad in relation to the substrate.

Abstract: A polishing composition includes an anionic abrasive; a pH adjuster; a transition metal catalyst; and an amino acid. A method of polishing a substrate includes the steps of: applying the polishing composition described herein to a surface of a substrate, wherein the surface comprises tungsten or molybdenum; and bringing a pad into contact with the surface of the substrate and moving the pad in relation to the substrate.

Abstract: Provided are engineered T-cell receptors comprising fusion proteins comprising a transmembrane domain and an intracellular domain capable of providing a stimulatory signal or an inhibitory signal, and immune cells comprising same.

Abstract: The use of oxidatively transformed carotenoid or a component thereof to enhance the immune response in a subject for the treatment of infection or to enhance the immune response to an antigen in a subject being immunized. Also disclosed are pharmaceutical compositions and kits containing the oxidatively transformed carotenoid.

Abstract: The present invention relates to a carrier for golf clubs that can be transformed into a substantially flat arrangement when not in use. The golf club carrier comprises at least one modular unit, wherein the modular unit comprises: (i) a support structure configured to be movable between a substantially flat position and a rolled position; (ii) a plurality of carrier members attached to the support structure in a spaced apart configuration, each carrier member comprising a closed bottom portion and an open top portion, wherein said open top portion can receive a golf club shaft; and (iii) a first fastening means attached to the support structure for releasably fastening to a support structure of a further modular unit or for releasably fastening to a cover structure which is configured to wrap around the support structure of the modular unit when the support structure is in a rolled position.

Abstract: The invention relates to a method of inhibiting chemotherapy induced upregulation of Cathepsin S on the surface of tumor cells, the method comprising the administration of a Cathepsin S inhibitor to said cells. Also provided is a therapy comprising an anti Cathepsin S antibody, in particular an anti-Cathepsin S antibody which does not inhibit the proteolytic effect of Cathepsin S but nevertheless inhibits angiogenesis and a combination treatment comprising a Cathepsin S inhibitor and a therapeutic agent.

Abstract: There is provided a method for suppressing a pro-inflammatory immune response in a cell, comprising providing to a cell sialic acid or analogs thereof, wherein the sialic acid or analogs are presented by a substrate such that a pro-inflammatory immune response in a cell is suppressed or an anti-inflammatory immune response is increased in a cell. Further, there is provided a method of treatment of inflammatory disease in a subject in need thereof. There is also provided a drug delivery device and a biomaterial which can modulate the inflammatory response in a subject.

Abstract: Described are cross-specific antibody molecules with binding specificity for both AREG and HBEGF. The antibody molecules may be used in methods of treatment of cancer and diseases associated with angiogenesis.

Abstract: The present invention relates to a recoil reducer for a firearm. The recoil reducer includes a means to reduce the energy transmitted from the firearm via the use of a soft viscoelastic gel, which is surrounded by means to further reduce the energy transmitted, above that provided solely by the characteristics of the gel, while at the same time holding the soft gel in place and assisting it to return to its pre-distortion state.

Abstract: Capacitive touch sensors are integrated with a head-mounted display (HMD) device or other video eyewear devices to create a more reliable and more intuitive user interface. The sensors, which may be implemented as an array, control various aspects of a left and right channel multimedia presentation, such as interpupillary distance or stereoscopic convergence, brightness, volume, or power mode.

Abstract: There is provided a method for suppressing a pro-inflammatory immune response in a cell, comprising providing to a cell sialic acid or analogs thereof, wherein the sialic acid or analogs are presented by a substrate such that a pro-inflammatory immune response in a cell is suppressed or an anti-inflammatory immune response is increased in a cell. Further, there is provided a method of treatment of inflammatory disease in a subject in need thereof. There is also provided a drug delivery device and a biomaterial which can modulate the inflammatory response in a subject.

Abstract: Audio in an audio conference is spatialized using either virtual sound-source positioning or sound-field capture. A spatial audio conference is provided between a local and remote parties using audio conferencing devices (ACDs) interconnected by a network. Each ACD captures spatial audio information from the local party, generates either one, or three or more, audio data streams which include the captured information, and transmits the generated stream(s) to each remote party. Each ACD also receives the generated audio data stream(s) transmitted from each of the remote parties, processes the received streams to generate a plurality of audio signals, and renders the signals to produce a sound-field that is perceived by the local party, where the sound-field includes the spatial audio information captured from the remote parties. A sound-field capture device is also provided which includes at least three directional microphones symmetrically configured about a center axis in a semicircular array.

Abstract: The use of oxidatively transformed carotenoid or a component thereof to enhance the immune response in a subject for the treatment of infection or to enhance the immune response to an antigen in a subject being immunized. Also disclosed are pharmaceutical compositions and kits containing the oxidatively transformed carotenoid.

Abstract: Described are cross-specific antibody molecules with binding specificity for both AREG and HBEGF. The antibody molecules may be used in methods of treatment of cancer and diseases associated with angiogenesis.

Abstract: The perceptual scalable audio coding/decoding technique lies in the use of a psychoacoustic mask to guide residue coding in enhancement layer coders. At the encoder, a psychoacoustic mask is calculated for the enhancement layer coders or is simply extracted from the coded base layer bitstream. One can also decode the coded base layer bitstream into the audio waveform, and calculate the psychoacoustic mask from the decoded base layer waveform. Furthermore, a predictive technology can be used to refine the psychoacoustic mask derived from the base layer bitstream to form a more accurate psychoacoustic mask of the enhancement layer. In addition, one can calculate the enhancement layer psychoacoustic mask from the original audio, and send the difference between the enhancement layer psychoacoustic mask and the base layer psychoacoustic mask as side information to the decoder. This psychoacoustic mask may then be used for the perceptual coding and decoding of the residue.