Abstract: Methods are provided for the treatment or prevention of metastasis by the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with a cell impermeable ENPP1 inhibitor to treat or prevent metastasis. Aspects of the methods include administering to a subject in need thereof a therapeutically effective amount of an immune checkpoint inhibitor, a chemotherapeutic agent, and/or radiation treatment, in combination with a therapeutically effective amount of a cell impermeable ENPP1 inhibitor to treat or prevent metastasis.

Abstract: Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with a cell impermeable ENPP1 inhibitor to inhibit cGAMP hydrolysis activity of ENPP1. Aspects of the methods include administering to a subject in need thereof a therapeutically effective amount of a CAR expressing immune cell in combination with a therapeutically effective amount of a cell impermeable ENPP1 inhibitor to inhibit the hydrolysis of cGAMP.

Abstract: In one embodiment, a processing device includes a plurality of display interfaces, a plurality of display controllers, and display synchronization circuitry. The display interfaces are used to interface with a plurality of display devices, and the display controllers are used to output video frames to the display devices via the display interfaces. Moreover, the display synchronization circuitry includes a clock synchronization interface and a frame synchronization interface. The clock synchronization interface is used to synchronize a clock rate across the display controllers, while the frame synchronization interface is used to synchronize a frame rate across the display controllers.

Abstract: The invention provides devices for active modification of thermal radiation, the devices comprising: (i) a substrate; (ii) one or more polymeric permeable membranes comprising an ionic liquid electrolyte; (iii) one or more electrodes comprising carbon nanotubes deposited onto the surface of at least one of the one or more polymeric membranes; and (iv) a protective encapsulation layer. The invention also provides methods of making such devices.

Abstract: An apparatus for and a method of analyzing a sample. A laser section may include a laser arranged to direct a laser beam in a first direction towards the sample. The laser beam ablating and ionizing at least a portion of the sample to generate ions. An ion source section may include a sample holder for holding the sample. At least one component is arranged to apply an electric field for extracting at least a portion of the ions to form an ion beam traveling in a second direction. A time-of-flight section may include a detector arranged to receive the ion beam.

Abstract: A guide wire safety device for preventing retained guidewire events comprises a mainbody component located between a Luer hub component for connection to a Luer hub and a locking sleeve component for connection to a catheter, wherein the main body component houses a means for gripping a guidewire.

Abstract: A polishing composition includes an anionic abrasive, a pH adjuster a low-k removal rate inhibitor, a ruthenium removal rate enhancer, and water. A method of polishing a substrate includes the steps of: applying the polishing composition described herein to a surface of a substrate, wherein the surface comprises ruthenium or a hard mask material; and bringing a pad into contact with the surface of the substrate and moving the pad in relation to the substrate.

Abstract: A polishing composition includes an anionic abrasive; a pH adjuster; a transition metal catalyst; and an amino acid. A method of polishing a substrate includes the steps of: applying the polishing composition described herein to a surface of a substrate, wherein the surface comprises tungsten or molybdenum; and bringing a pad into contact with the surface of the substrate and moving the pad in relation to the substrate.

Abstract: Provided are engineered T-cell receptors comprising fusion proteins comprising a transmembrane domain and an intracellular domain capable of providing a stimulatory signal or an inhibitory signal, and immune cells comprising same.

Abstract: A firearm flash arrestor device may include a housing having a housing cavity. An entrance cap, having an entrance aperture, may be coupled to a first end of the housing, and an exit cap, having an exit aperture, may be coupled to an opposing second end of the housing. The device may also include one or more baffles configured to be positioned within the housing cavity. Each baffle may include a baffle wall that may be coupled to a baffle plate, a central aperture that may be disposed in the baffle plate, and one or more peripheral apertures that may be formed into the baffle plate and baffle wall. The one or more baffles may be disposed in the housing cavity so that the central aperture of each baffle is aligned with the entrance aperture and exit aperture to provide a path for a projectile to travel through the device.

Abstract: In one embodiment, a processing device includes a plurality of display interfaces, a plurality of display controllers, and display synchronization circuitry. The display interfaces are used to interface with a plurality of display devices, and the display controllers are used to output video frames to the display devices via the display interfaces. Moreover, the display synchronization circuitry includes a clock synchronization interface and a frame synchronization interface. The clock synchronization interface is used to synchronize a clock rate across the display controllers, while the frame synchronization interface is used to synchronize a frame rate across the display controllers.

Abstract: The invention relates to a method for determining a scale inhibitor concentration in a sample comprising at least a first scale inhibitor, which is a synthetic organic compound comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample to interact with a reagent comprising a lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement, and the concentration of the at least first scale inhibitor in the sample is determined by using the detected sample signal.

Abstract: Systems, devices, and methods for impacting, by a small unmanned aerial vehicle (SUAV), a net having at least three sides; and converting the kinetic energy of the SUAV into at least one of: elastic potential energy of one or more tensioned elastic cords connected to at least one corner of the net, gravitational potential energy of a frame member connected to at least one corner of the net, rotational kinetic energy of the frame member connected to at least one corner of the net, and elastic potential energy of the frame member connected to at least one corner of the net.

Abstract: The use of oxidatively transformed carotenoid or a component thereof to enhance the immune response in a subject for the treatment of infection or to enhance the immune response to an antigen in a subject being immunized. Also disclosed are pharmaceutical compositions and kits containing the oxidatively transformed carotenoid.

Abstract: A system for in-situ identification of a working fluid disposed in at least one piece of equipment, the system including: a working fluid reservoir that contains the working fluid; an in-situ sensor disposed in the working fluid reservoir such that it detects properties of the working fluid or computes properties from the generated spectra of the working fluid; a transmitter that transmits the detected spectra of the working fluid and equipment identification information; and a cloud computing system that receives the detected spectra and the equipment identification information transmitted from the transmitter, wherein the cloud computing system compares the spectra and equipment identification information against a reference database to determine whether or not the spectra of the working fluid substantially matches the stored reference spectra associated with the expected or specified fluid for the equipment.

Abstract: A method for improving wear control, while maintaining or improving energy efficiency, in an engine or other mechanical component lubricated with a lubricating oil, by using as the lubricating oil a formulated oil. The formulated oil includes at least one lubricating oil base stock having one or more liquid crystals represented by the formula: R1-(A)m-Y—(B)n—R2 wherein R1 and R2 are the same or different and are a substituted or unsubstituted, hydrocarbon, alkoxy or alkylthio group having from 2 to 24 carbon atoms; A and B are the same or different and are a cycloaliphatic group or aromatic group, provided at least one of A and B is an aromatic group; Y is a covalent bond, —CH2-CH2-, —CH?CH—, —OCOO—, —CO—, —CSO—, —CSS—, —CS—, —O—, —S—, —SO—, —SO2-, —CH2O—, —OCH2O—, —NO—, —ONO2, or —C?N; and m and n are independently 0, 1, 2 or 3. The lubricating oil base stock has a kinematic viscosity of 2 cSt to 200 cSt at 40° C., and 1 cSt to 25 cSt at 100° C.

Abstract: A method for improving friction and wear control, while maintaining or improving energy efficiency, in an engine or other mechanical component lubricated with a lubricating oil, by using as the lubricating oil a formulated oil. The formulated oil has a composition including at least one lubricating oil base stock. The at least one lubricating oil base stock includes one or more liquid crystals, wherein the one or more liquid crystals are represented by the formula: A?(R1)n wherein A is a mono-ring or a multi-ring aromatic group, R1 is the same or different and is a substituted or unsubstituted, hydrocarbon, alkoxy, or alkylthio group having from 2 to 24 carbon atoms, and n is a value from 1 to 12. The lubricating oil base stock has a kinematic viscosity of 2 cSt to 200 cSt at 40° C., as determined according to ASTM D445, and a kinematic viscosity of 1 cSt to 25 cSt at 100° C., as determined according to ASTM D445.

Abstract: The invention relates to a method for analysing a sample comprising at least a first and a second scale inhibitor, which scale inhibitors are synthetic organic compounds comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample interact with a reagent comprising lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement. The total concentration of the first and the second scale inhibitor is determined by using the detected sample signal, and the concentration of the first scale inhibitor in the sample is determined. The concentration of the second scale inhibitor is determined mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration.

Abstract: Systems, devices, and methods for impacting, by a small unmanned aerial vehicle (SUAV), a net having at least three sides; and converting the kinetic energy of the SUAV into at least one of: elastic potential energy of one or more tensioned elastic cords connected to at least one corner of the net, gravitational potential energy of a frame member connected to at least one corner of the net, rotational kinetic energy of the frame member connected to at least one corner of the net, and elastic potential energy of the frame member connected to at least one corner of the net.

Abstract: The invention relates to a method for determining a scale inhibitor concentration in a sample comprising at least a first scale inhibitor, which is a synthetic organic compound comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample to interact with a reagent comprising a lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement, and the concentration of the at least first scale inhibitor in the sample is determined by using the detected sample signal.