Patents by Inventor James K. Blodgett

James K. Blodgett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic suppression of specific immune response by administration of oligomeric forms of antigen of controlled chemistry
    Patent number: 6375951
    Abstract: The invention features a non-immunogenic construct for reducing a non-primary antibody response to an epitope of a T-dependent antigen. The construct is free of high molecular weight immunostimulatory molecules and contains copies of the epitope which bind to a B cell membrane immunoglobulin receptor specific for the epitope but fail to form an imnunon.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: April 23, 2002
    Assignee: Johns Hopkins University
    Inventors: Howard M. Dintzis, Renée Z. Dintzis, James K. Blodgett, John C. Cheronis, Gary Kirschenheuter
  • Bradykinin antagonist
    Patent number: 6075120
    Abstract: A bradykinin antagonist of the formula:(BKAn)(X)(Y)where BKAn is a bradykinin antagonist peptide; Y is a pharmacore; and X is a bridging link chemically joining the BKAn and Y components.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: June 13, 2000
    Assignee: Cortech, Inc.
    Inventors: John C. Cheronis, James K. Blodgett, Val Smith Goodfellow, Manoj Vinayak Marathe, Lyle W. Spruce, Eric T. Whalley
  • Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry
    Patent number: 6022544
    Abstract: The invention features a method for reducing an undesired antibody response in a mammal by administering to the mammal a non-immunogenic construct which is free of high molecular weight immunostimulatory molecules. The construct which contains at least two copies of a B cell membrane immunoglobulin receptor epitope bound to a pharmaceutically acceptable non-immunogenic carrier directly binds to B cell membrane immunoglobulin receptors but fails to form an immunon.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: February 8, 2000
    Assignee: The John Hopkins University
    Inventors: Howard M. Dintzis, Renee Z. Dintzis, James K. Blodgett, John C. Cheronis, Gary Kirschenheuter
  • Bradykinin antagonists
    Patent number: 5863899
    Abstract: A bradykinin antagonist of the formula:(BKAn) (X) (Y)where BKAn is a bradykinin antagonist peptide; Y is a Pharmacophore; and X is a bridging link chemically joining the BKAn and Y components.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: January 26, 1999
    Assignee: Cortech, Inc.
    Inventors: John C. Cheronis, James K. Blodgett, Val Smith Goodfellow, Manoj Vinayak Marathe, Lyle W. Spruce, Eric T. Whalley
  • Bradykinin antagonists
    Patent number: 5635593
    Abstract: A brandykinin antagonist of the formula:X(BKA).sub.nwherein BKA is the peptide chain of a bradykinin antagonist peptide, X is a linking group and n is a whole number greater than 1. The BKA substituents may be the same or different. Monomeric antagonists of the formula X(BKA) are also disclosed. Also disclosed are bradykinin antagonists of the formula:(Y)(X)(BKA)where X and BKA have the meanings indicated above and Y is the peptide chain of an antagonist or agonist for a non-bradykinin receptor.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: June 3, 1997
    Assignee: Cortech, Inc.
    Inventors: John C. Cheronis, James K. Blodgett, Eric T. Whalley, Shadrach R. Eubanks, Lisa G. Allen, Khe T. Nguyen
  • Bradykinin antagonists
    Patent number: 5620958
    Abstract: A bradykinin antagonist of the formula:X(BKA).sub.nwherein BKA is the peptide chain of a bradykinin antagonist peptide, X is a linking group and n is a whole number greater than 1. The BKA substituents may be the same or different. Monomeric antagonists of the formula X(BKA) are also disclosed. Also disclosed are bradykinin antagonists of the formula:(Y)(X)(BKA)where X and BKA have the meanings indicated above and Y is the peptide chain of an antagonist or agonist for a non-bradykinin receptor.
    Type: Grant
    Filed: April 13, 1994
    Date of Patent: April 15, 1997
    Assignee: Coretech, Inc.
    Inventors: John C. Cheronis, James K. Blodgett, Eric T. Whalley, Shadrach R. Eubanks, Lisa G. Allen, Khe T. Nguyen
  • Compounds and methods for suppressing an immune response to sulfomethoxozale containing substances
    Patent number: 5599912
    Abstract: The present invention provides methods of detecting and suppressing an undesired immune response, and agents suitable for use therein. More specifically, the present invention, provides agents and methods for their use, directed at detecting and suppressing an undesired immune response to compositions containing sulfamethoxazole.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: February 4, 1997
    Assignee: Coretech, Inc.
    Inventors: Timothy C. Rodell, Vidal De La Cruz, Catherine McCall, James K. Blodgett, Donald A. McLeod