Patents by Inventor James K. Kirklin

James K. Kirklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENHANCING COAGULATION OR REDUCING FIBRINOLYSIS
    Publication number: 20140234432
    Abstract: Methods for controlling bleeding (e.g., enhancing coagulation and reducing fibrinolysis) in a subject are disclosed. The methods include selecting a subject in need of enhanced coagulation or reduced fibrinolysis, and administering to the subject a carbon monoxide releasing molecule (CORM). Examples of CORMs include tricarbonyldichlororuthenium (II) dimer, tricarbonylchloro-(glycinato)ruthenium (II), sodium boranocarbonate, dimanganese decacarbonyl, and iron pentacarbonyl. Further disclosed are compositions and methods for treating a subject in need of a blood product by administering to the subject a composition including a CORM and a blood product (e.g., cryoprecipitate or fresh frozen plasma).
    Type: Application
    Filed: February 21, 2014
    Publication date: August 21, 2014
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: Vance G. Nielsen, James F. George, James K. Kirklin
  • Enhancing coagulation or reducing fibrinolysis
    Patent number: 8697747
    Abstract: Methods for controlling bleeding (e.g., enhancing coagulation and reducing fibrinolysis) in a subject are disclosed. The methods include selecting a subject in need of enhanced coagulation or reduced fibrinolysis, and administering to the subject a carbon monoxide releasing molecule (CORM). Examples of CORMs include tricarbonyldichloro-ruthenium (II) dimer, tricarbonylchloro-(glycinato)ruthenium (II), sodium boranocarbonate, dimanganese decacarbonyl, and iron pentacarbonyl. Further disclosed are compositions and methods for treating a subject in need of a blood product by administering to the subject a composition including a CORM and a blood product (e.g., cryoprecipitate or fresh frozen plasma).
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: April 15, 2014
    Assignee: THe UAB Research Foundation
    Inventors: Vance G. Nielsen, James F. George, James K. Kirklin
  • ENHANCING COAGULATION OR REDUCING FIBRINOLYSIS
    Publication number: 20120045518
    Abstract: Methods for controlling bleeding (e.g., enhancing coagulation and reducing fibrinolysis) in a subject are disclosed. The methods include selecting a subject in need of enhanced coagulation or reduced fibrinolysis, and administering to the subject a carbon monoxide releasing molecule (CORM). Examples of CORMs include tricarbonyldichloro-ruthenium (II) dimer, tricarbonylchloro-(glycinato)ruthenium (II), sodium boranocarbonate, dimanganese decacarbonyl, and iron pentacarbonyl. Further disclosed are compositions and methods for treating a subject in need of a blood product by administering to the subject a composition including a CORM and a blood product (e.g., cryoprecipitate or fresh frozen plasma).
    Type: Application
    Filed: March 5, 2010
    Publication date: February 23, 2012
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: Vance G. Nielsen, James F. George, James K. Kirklin