Abstract: Disclosed herein are static mixer assemblies, and related methods of fabrication and use. The disclosure provides advantageous static mixer assemblies, and improved systems/methods for utilizing and/or fabricating the static mixer assemblies. The disclosure provides static mixer assemblies fabricated at least in part by additive manufacturing (e.g., via a 3D printing process, such as, for example, via a fused deposition modeling (“FDM”) process), and related methods of use. The static mixer assemblies of the present disclosure can be particularly well-suited for applications such as, without limitation, high performance liquid chromatography (“HPLC”) applications. The additive manufacturing or 3D printing processes (e.g., FDM or LAMT techniques) as described herein can be used to manufacture static mixer assemblies with complex shapes/designs (e.g., and that are highly effective yet small in shape).

Abstract: The present disclosure provides advantageous porous assemblies, and improved systems and methods for utilizing and/or fabricating the porous assemblies. More particularly, the present disclosure provides porous assemblies fabricated at least in part by additive manufacturing (e.g., via a 3D printing process, such as, for example, via an electron beam additive manufacturing process, via a laser additive manufacturing technology, via an inkjet or a binder jet additive manufacturing process, etc.), the porous assemblies including a porous monolith support structure or substrate for a sensitive or active layer of a multi-layer application (e.g., for sensitive/active layers in fuel cell/electrolyzer/battery and other multi-layer applications).

Abstract: Disclosed herein are phase separator devices, and related methods of fabrication and use. The disclosure provides improved phase separator devices for phase separation of input feeds, and systems/methods for utilizing and fabricating the devices. The disclosure provides phase separator devices utilizing inertial separation and porous media extraction for the phase separation of two-phase input feeds (e.g., to separate an input feed of a two-phase mixture to a first phase output (e.g., to a liquid output flow) and to a second phase output (e.g., to a gas output flow)). The device can separate a mixed fluid flow of both liquid and gases. The liquid and gas can include liquid and vapor phases of the same chemical/constituent (e.g., ammonia), or may include liquid and gases of two different constituents (e.g., liquid water and air). The phase separator devices can be utilized at standard gravity to micro-gravity to zero gravity environments.

Abstract: The present disclosure provides advantageous rotary interfaces for fluid assemblies (e.g., rotary interfaces for fluid flow in bioreactor applications), and related methods of fabrication and use. More particularly, the present disclosure provides improved rotary interfaces for fluid flow through porous impellers for filtration and/or sparging for fluid assemblies (e.g., bioreactor applications), and related methods of fabrication and use. Disclosed herein is a fluid assembly (e.g., bioreactor) that includes a porous impeller which is in fluid communication with a hollow shaft that can be used to transport a reaction fluid to an external storage tank or the like. The fluid assembly/bioreactor can include a coupling mechanism that transmits rotary motion from a motor to a primary shaft and then to a hollow secondary shaft, while at the same time permitting removal of a filtrate from the fluid assembly or bioreactor via the hollow secondary shaft and a porous impeller.

Abstract: The present disclosure relates generally to the field of medical devices and drug delivery. In particular, the present disclosure relates to implantable medical devices, systems and methods for controlled and consistent drug release through a porous body into a patient.

Abstract: Disclosed herein are phase separator devices, and related methods of fabrication and use. The disclosure provides improved phase separator devices for phase separation of input feeds, and systems/methods for utilizing and fabricating the devices. The disclosure provides phase separator devices utilizing inertial separation and porous media extraction for the phase separation of two-phase input feeds (e.g., to separate an input feed of a two-phase mixture to a first phase output (e.g., to a liquid output flow) and to a second phase output (e.g., to a gas output flow)). The device can separate a mixed fluid flow of both liquid and gases. The liquid and gas can include liquid and vapor phases of the same chemical/constituent (e.g., ammonia), or may include liquid and gases of two different constituents (e.g., liquid water and air). The phase separator devices can be utilized at standard gravity to micro-gravity to zero gravity environments.

Abstract: Disclosed herein are advantageous phase separator devices, and related methods of fabrication and use thereof. The present disclosure provides improved phase separator devices for phase separation of feedstreams, and improved systems/methods for utilizing and fabricating the phase separator devices. More particularly, the present disclosure provides porous (e.g., three-dimensional gradient porous) phase separator devices for phase separation of fluid mixtures (e.g., to separate a two-phase fluid mixture) to a first fluid phase flow (e.g., to a liquid flow) and to a second fluid phase flow (e.g., to a gas flow). At least a portion of the phase separator devices of the present disclosure can be fabricated via machining, powder metallurgy (e.g., sintering), and/or produced utilizing additive manufacturing techniques.

Abstract: A static mixer device comprising a housing having a proximal end, a distal end, and an opening extending between the proximal and distal ends. In certain embodiments, a plurality of metal frits is positioned within the opening of the housing, each of the metal frits extending across a cross-sectional dimension of the opening and having interconnected porosity. In other embodiments, one or more mixer elements fabricated using laser additive manufacturing technology and having novel configurations are positioned within the opening of the housing. In yet other embodiments, the housing comprises multiple openings having different diameters from each other, with each opening either extending through the housing with a constant diameter or with one or more of the openings having a varying diameter.

Abstract: Various embodiments are generally directed to techniques for splitting fluid flows with porous medium, such as a porous medium with metal particles, for instance. Some embodiments are particularly directed to a flow splitting assembly that creates a differential flow at a calibrated flow split. In one or more embodiments, for example, an apparatus for flow spitting may include a manifold comprising first, second and third manifold openings in fluid communication. In one or more such embodiments, introduction of a flow to the first manifold opening via an inlet filter may cause a differential flow at a calibrated flow split between a first restrictor coupled to the second opening of the manifold and a second restrictor coupled to the third opening of the manifold. In various embodiments, each restrictor may include one or more porous medium composed of metal particles.

Abstract: A static mixer device comprising a housing having a proximal end, a distal end, and an opening extending between the proximal and distal ends. In certain embodiments, a plurality of metal frits is positioned within the opening of the housing, each of the metal frits extending across a cross-sectional dimension of the opening and having interconnected porosity. In other embodiments, one or more mixer elements fabricated using laser additive manufacturing technology and having novel configurations are positioned within the opening of the housing. In yet other embodiments, the housing comprises multiple openings having different diameters from each other, with each opening either extending through the housing with a constant diameter or with one or more of the openings having a varying diameter.

Abstract: A composite structure includes a substrate with pores of a first mean pore size and a coating on at least one surface of that substrate. This coating has pores of a second mean pore size where the first mean pore size is equal to or greater than said second mean pore size. When the pore size of the coating is effective to capture particulate greater than 0.2 micron, the composite may be formed into a filter effective to remove microbes from a fluid medium. One method to form the porous coating on the substrate includes: (1) forming a suspension of sinterable particles in a carrier fluid and containing the suspension in a reservoir; (2) maintaining the suspension by agitation; (3) transferring the suspension to an ultrasonic spray nozzle; (4) applying a first coating of the suspension to the substrate; and (5) sintering the sinterable particles to the substrate.

Abstract: A composite structure includes a substrate with pores of a first mean pore size and a coating on at least one surface of that substrate. This coating has pores of a second mean pore size where the first mean pore size is equal to or greater than said second mean pore size. When the pore size of the coating is effective to capture particulate greater than 0.2 micron, the composite may be formed into a filter effective to remove microbes from a fluid medium. One method to form the porous coating on the substrate includes the steps of: (a) forming a suspension of sinterable particles in a carrier fluid and containing the suspension in a reservoir; (b) maintaining the suspension by agitation in the reservoir; (c) immersing the substrate in the reservoir; (c) applying a first coating of the suspension to the substrate; (d) removing the substrate with the applied first coating from the reservoir; and (e) sintering the sinterable particles to the substrate thereby forming a coated substrate.

Abstract: A composite structure includes a substrate with pores of a first mean pore size and a coating on at least one surface of that substrate. This coating has pores of a second mean pore size where the first mean pore size is equal to or greater than said second mean pore size. When the pore size of the coating is effective to capture particulate greater than 0.2 micron, the composite may be formed into a filter effective to remove microbes from a fluid medium. One method to form the porous coating on the substrate includes: (1) forming a suspension of sinterable particles in a carrier fluid and containing the suspension in a reservoir; (2) maintaining the suspension by agitation; (3) transferring the suspension to an ultrasonic spray nozzle; (4) applying a first coating of the suspension to the substrate; and (5) sintering the sinterable particles to the substrate.

Abstract: A method for forming a porous coating with nanosize pores on a substrate includes the steps of (a) forming a suspension of sinterable particles in a carrier fluid; (b) maintaining the suspension by agitating the carrier fluid; (c) applying a first coating of the suspension to the substrate; and (d) sintering the sinterable particles to the substrate. A thin layer of this nanoporous coating is deposited onto a substrate having micropores. The substrate provides strength and structural support while the properties of the nano powder layer controls flow and filtration aspects of the device. This composite has sufficient strength for handling and use in industrial processes. Since the nano powder layer is thin, the pressure drop across the layer is substantially less than conventional thicker nano powder structures.