Patents by Inventor James Karras

James Karras has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted Macrocyclic Compounds and Related Methods of Treatment
    Publication number: 20240368182
    Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.
    Type: Application
    Filed: April 5, 2024
    Publication date: November 7, 2024
    Inventors: Lewis D. PENNINGTON, Younggi CHOI, Hoan HUYNH, Brian M. AQUILA, Ingo Andreas MUGGE, Yuan HU, James R. WOODS, Brian Kenneth RAYMER, Jörg Martin BENTZIEN, Jonathan Ward LEHMANN, Michael R. HALE, Srinivasa KARRA, Roman A. VALIULIN, Daljit MATHARU
  • Substituted macrocyclic compounds and related methods of treatment
    Patent number: 12054495
    Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.
    Type: Grant
    Filed: November 22, 2022
    Date of Patent: August 6, 2024
    Assignee: Alkermes, Inc.
    Inventors: Lewis D. Pennington, Younggi Choi, Hoan Huynh, Brian M. Aquila, Ingo Andreas Mugge, Yuan Hu, James R. Woods, Roman A. Valiulin, Brian Kenneth Raymer, Jörg Martin Bentzien, Michael R. Hale, Jonathan Ward Lehmann, Daljit Matharu, Srinivasa Karra
  • Security platform
    Patent number: 11625460
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for interconnecting devices. One of the methods includes authenticating, by a security platform, a user. The method includes generating, by the security platform, an authentication token for the user. The method includes receiving a selection of an IoT application by the user, the IoT application configured to control an IoT device. The method includes providing, by the security platform, the authentication token to the IoT application to authenticate the user with the selected application. The method also includes providing, by the selected application, control of the IoT device to the user.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: April 11, 2023
    Assignee: United Services Automobile Association (USAA)
    Inventors: Thomas Bret Buckingham, James Karras, John Shelton, Michael Wayne Lester, Bharat Prasad, James Eric McCarty, Gabriel C. Fernandez, Debra Randall Casillas, Sudarshan Rangarajan, Christopher Thomas Wilkinson
  • Security platform
    Patent number: 11218478
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for interconnecting devices. One of the methods includes authenticating, by a security platform, a user. The method includes generating, by the security platform, an authentication token for the user. The method includes receiving a selection of an IoT application by the user, the IoT application configured to control an IoT device. The method includes providing, by the security platform, the authentication token to the IoT application to authenticate the user with the selected application. The method also includes providing, by the selected application, control of the IoT device to the user.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: January 4, 2022
    Assignee: United Services Automobile Association (USAA)
    Inventors: Thomas Bret Buckingham, James Karras, John Shelton, Michael Wayne Lester, Bharat Prasad, James Eric McCarty, Gabriel C. Fernandez, Debra Randall Casillas, Sudarshan Rangarajan, Christopher Thomas Wilkinson
  • Security platform
    Patent number: 10425414
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for interconnecting devices. One of the methods includes authenticating, by a security platform, a user. The method includes generating, by the security platform, an authentication token for the user. The method includes receiving a selection of an IoT application by the user, the IoT application configured to control an IoT device. The method includes providing, by the security platform, the authentication token to the IoT application to authenticate the user with the selected application. The method also includes providing, by the selected application, control of the IoT device to the user.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: September 24, 2019
    Assignee: United Services Automobile Association (USAA)
    Inventors: Thomas Bret Buckingham, James Karras, John Shelton, Michael Wayne Lester, Bharat Prasad, James Eric McCarty, Gabriel C. Fernandez, Debra Randall Casillas, Sudarshan Rangarajan, Christopher Thomas Wilkinson
  • MODULATION OF STAT5 EXPRESSION
    Publication number: 20100311814
    Abstract: Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT5 are provided.
    Type: Application
    Filed: February 22, 2010
    Publication date: December 9, 2010
    Applicant: ISIS PHARMACEUTICALS, INC.
    Inventors: SUSAN M. FREIER, JAMES KARRAS
  • Modulation of Stat 6 Expression for the Treatment of Airway Hyperresponsiveness
    Publication number: 20100202977
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of STAT 6 in a cell, tissue, or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of STAT 6, airway hyperresponsiveness, and/or pulmonary inflammation.
    Type: Application
    Filed: May 12, 2006
    Publication date: August 12, 2010
    Inventors: James Karras, Jeffrey R. Crosby, Brett P. Monia, Susan M. Freier
  • MODULATION OF STAT 6 EXPRESSION FOR THE TREATMENT OF AIRWAY HYPERRESPONSIVENESS
    Publication number: 20090191133
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of STAT 6 in a cell, tissue, or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of STAT 6, airway hyperresponsiveness, and/or pulmonary inflammation.
    Type: Application
    Filed: June 26, 2008
    Publication date: July 30, 2009
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: James KARRAS, Jeffrey CROSBY, Brett MONIA, Susan Freier
  • Isis Pharmaceuticals, Inc.
    Publication number: 20080311052
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of STAT 6 in a cell, tissue, or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of STAT 6, airway hyperresponsiveness, and/or pulmonary inflammation.
    Type: Application
    Filed: May 12, 2006
    Publication date: December 18, 2008
    Inventors: James Karras, Jeffrey R. Crosby, Brett P. Monia, Susan M. Freier
  • ANTISENSE OLIGONUCLEOTIDE MODULATION OF STAT3 EXPRESSION
    Publication number: 20080051359
    Abstract: Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion of apoptosis are provided. Methods for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 or insufficient apoptosis are also provided.
    Type: Application
    Filed: July 27, 2007
    Publication date: February 28, 2008
    Inventor: James Karras
  • OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN
    Publication number: 20080027019
    Abstract: Compositions and methods for the treatment of asthma with oligonucleotides which specifically hybridize with nucleic acids encoding B7 proteins.
    Type: Application
    Filed: May 14, 2007
    Publication date: January 31, 2008
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Timothy Vickers, C. Bennett, Susan Freier, James Karras
  • MODULATION OF STAT5 EXPRESSION
    Publication number: 20070293663
    Abstract: Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT5 are provided.
    Type: Application
    Filed: November 3, 2006
    Publication date: December 20, 2007
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Susan Freier, James Karras
  • DOUBLE STRANDED NUCLEIC ACID MOLECULES TARGETED TO IL-4 RECEPTOR ALPHA
    Publication number: 20070270366
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
    Type: Application
    Filed: December 19, 2006
    Publication date: November 22, 2007
    Inventors: James Karras, Susan Gregory, Andrew Watt, Jeffrey Crosby
  • COMPOSITIONS AND THEIR USES DIRECTED TO IL-4R ALPHA
    Publication number: 20070161594
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-?, airway hyperresponsiveness, and/or pulmonary inflammation.
    Type: Application
    Filed: October 11, 2006
    Publication date: July 12, 2007
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: James Karras, Susan Gregory, Susan Freier, Kenneth Dobie
  • COMPOSITIONS AND THEIR USES DIRECTED TO IL-4R ALPHA
    Publication number: 20070161593
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-?, airway hyperresponsiveness, and/or pulmonary inflammation.
    Type: Application
    Filed: October 11, 2006
    Publication date: July 12, 2007
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: James Karras, Susan Gregory, Susan Freier, William Gaarde, Mausumee Guha
  • Compositions and methods for the modulation of the expression of b7 protein
    Publication number: 20070135364
    Abstract: Anti sense oligonucleotide compositions which specifically hybridize with nucleic acids encoding B7 proteins, and use of these compositions for inhibiting expression of B7 mRNA.
    Type: Application
    Filed: May 19, 2004
    Publication date: June 14, 2007
    Inventors: C. Bennett, Timothy Vickers, James Karras, Susan Freier
  • Modulation of STAT5 expression
    Patent number: 7176303
    Abstract: Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT5 are provided.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: February 13, 2007
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Susan M. Freier, James Karras
  • Modulation of STAT 6 expression for the treatment of airway hyperresponsiveness
    Publication number: 20060258610
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of STAT 6 in a cell, tissue, or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of STAT 6, airway hyperresponsiveness, and/or pulmonary inflammation.
    Type: Application
    Filed: May 11, 2006
    Publication date: November 16, 2006
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: James Karras, Jeffrey Crosby, Brett Monia, Susan Freier
  • Compositions and their uses directed to thymus and activation-regulated chemokine (TARC)
    Publication number: 20060234972
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of TARC in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of TARC, airway hyperresponsiveness, and/or pulmonary inflammation.
    Type: Application
    Filed: March 27, 2006
    Publication date: October 19, 2006
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: James Karras, Kenneth Dobie
  • Antisense oligonucleotide modulation of STAT3 expression
    Publication number: 20060217339
    Abstract: Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion of apoptosis are provided. Methods for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 or insufficient apoptosis are also provided.
    Type: Application
    Filed: March 15, 2006
    Publication date: September 28, 2006
    Inventor: James Karras