Patents by Inventor James Kealey
James Kealey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11939584Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.Type: GrantFiled: July 31, 2021Date of Patent: March 26, 2024Assignee: PRECIGEN, INC.Inventors: Xinhua Zhao, Mark Anton Held, Tina Huynh, Lily Yuin Chao, Na Trinh, Matthias Helmut Schmalisch, Bryan Yeh, James Kealey, Kevin Lee Dietzel
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Patent number: 11905513Abstract: Methods of genetically modifying microorganisms using advanced genome editing are disclosed. Methods of modifying the genome of these microorganisms for point mutations, deletions, and DNA insertions are also disclosed. Further, inhibiting expression of genes without manipulating the genome of the microorganism is disclosed. In some cases, the microorganism can be a methylotroph, e.g., a methanotroph.Type: GrantFiled: October 11, 2018Date of Patent: February 20, 2024Assignee: MBP TITAN, LLCInventors: Xuezhi Li, James Kealey, Kevin Lee Dietzel
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Publication number: 20230051667Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as isobutanol are disclosed. For example, genetically modified methanotrophs that are capable of generating isobutanol at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.Type: ApplicationFiled: July 11, 2022Publication date: February 16, 2023Applicant: PRECIGEN, INC.Inventors: Jeffrey David ORTH, Louis A. CLARK, Lily Yuin CHAO, Na My TRINH, Christopher Cheyney FARWELL, Xinhua ZHAO, Matthias Helmut SCHMALISCH, Grayson Thomas WAWRZYN, Xuezhi LI, Mark Anton HELD, Kevin Lee DIETZEL, James KEALEY
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Patent number: 11421235Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into multicarbon products. Methods of making these genetically modified microorganisms and methods of using them. Vectors encoding enzymes for use in converting carbon substrates into multicarbon products.Type: GrantFiled: April 27, 2018Date of Patent: August 23, 2022Assignee: PRECIGEN, INC.Inventors: Jeffrey David Orth, Louis A. Clark, Lily Yuin Chao, Na My Trinh, Christopher Cheyney Farwell, Xinhua Zhao, Matthias Helmut Schmalisch, Grayson Thomas Wawrzyn, Xuezhi Li, Mark Anton Held, Kevin Lee Dietzel, James Kealey
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Publication number: 20220112506Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO; 1,4-BDO; isobutyraldehyde; isobutanol; 1-butanol; n-butanol; ethanol; fatty alcohols; and fatty acid methyl ester are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO; 1,4-BDO; isobutyraldehyde; isobutanol; 1-butanol; n-butanol; ethanol; fatty alcohols; and fatty acid methyl ester at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed. These microorganisms and methods make use of molecular switches to regulate gene expression.Type: ApplicationFiled: November 8, 2021Publication date: April 14, 2022Applicant: PRECIGEN, INC.Inventors: Mark Anton HELD, Xinhua ZHAO, Lily Yuin CHAO, Na TRINH, James KEALEY, Kevin Lee DIETZEL
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Publication number: 20220064677Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 1,4-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 1,4-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.Type: ApplicationFiled: September 13, 2021Publication date: March 3, 2022Applicant: PRECIGEN, INC.Inventors: Xinhua ZHAO, Tina HUYNH, Jeffrey ORTH, Lily Yuin CHAO, James KEALEY
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Publication number: 20220049259Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.Type: ApplicationFiled: July 31, 2021Publication date: February 17, 2022Applicant: PRECIGEN, INC.Inventors: Xinhua ZHAO, Mark Anton HELD, Tina HUYNH, Lily Yuin CHAO, Na TRINH, Matthias Helmut SCHMALISCH, Bryan YEH, James KEALEY, Kevin Lee DIETZEL
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Patent number: 11198877Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO; 1,4-BDO; isobutyraldehyde; isobutanol; 1-butanol; n-butanol; ethanol; fatty alcohols; and fatty acid methyl ester are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO; 1,4-BDO; isobutyraldehyde; isobutanol; 1-butanol; n-butanol; ethanol; fatty alcohols; and fatty acid methyl ester at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed. These microorganisms and methods make use of molecular switches to regulate gene expression.Type: GrantFiled: January 30, 2018Date of Patent: December 14, 2021Assignee: PRECIGEN, INC.Inventors: Mark Anton Held, Xinhua Zhao, Lily Yuin Chao, Na Trinh, James Kealey, Kevin Lee Dietzel
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Patent number: 11155837Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 1,4-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 1,4-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.Type: GrantFiled: March 13, 2018Date of Patent: October 26, 2021Assignee: PRECIGEN, INC.Inventors: Xinhua Zhao, Tina Huynh, Jeffrey Orth, Lily Yuin Chao, James Kealey
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Publication number: 20210317446Abstract: Methods of genetically modifying microorganisms using advanced genome editing are disclosed. Methods of modifying the genome of these microorganisms for point mutations, deletions, and DNA insertions are also disclosed. Further, inhibiting expression of genes without manipulating the genome of the microorganism is disclosed. In some cases, the microorganism can be a methylotroph, e.g., a methanotroph.Type: ApplicationFiled: October 11, 2018Publication date: October 14, 2021Applicant: MBP TITAN LLCInventors: Xuezhi Li, James Kealey, Kevin Lee Dietzel
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Patent number: 11111496Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.Type: GrantFiled: January 30, 2018Date of Patent: September 7, 2021Assignee: PRECIGEN, INC.Inventors: Xinhua Zhao, Mark Anton Held, Tina Huynh, Lily Yuin Chao, Na Trinh, Matthias Helmut Schmalisch, Bryan Yeh, James Kealey, Kevin Lee Dietzel
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Publication number: 20210115452Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as isobutanol are disclosed. For example, genetically modified methanotrophs that are capable of generating isobutanol at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.Type: ApplicationFiled: April 27, 2017Publication date: April 22, 2021Inventors: Jeffrey David ORTH, Louis A. CLARK, Lily Yuin CHAO, Na My TRINH, Christopher Cheyney FARWELL, Xinhua ZHAO, Matthias Helmut SCHMALISCH, Grayson Thomas WAWRZYN, Xuezhi LI, Mark Anton HELD, Kevin Lee DIETZEL, James KEALEY
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Publication number: 20200115713Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.Type: ApplicationFiled: January 30, 2018Publication date: April 16, 2020Inventors: Xinhua ZHAO, Mark Anton HELD, Tina HUYNH, Lily Yuin CHAO, Na TRINH, Matthias Helmut SCHAMLISCH, Bryan YEH, James KEALEY, Kevin Lee DIETZEL
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Publication number: 20200040366Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 1,4-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 1,4-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.Type: ApplicationFiled: March 13, 2018Publication date: February 6, 2020Inventors: Xinhua ZHAO, Tina HUYNH, Jeffrey ORTH, Lily Yuin CHAO, James KEALEY
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Publication number: 20200040344Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO; 1,4-BDO; isobutyraldehyde; isobutanol; 1-butanol; n-butanol; ethanol; fatty alcohols; and fatty acid methyl ester are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO; 1,4-BDO; isobutyraldehyde; isobutanol; 1-butanol; n-butanol; ethanol; fatty alcohols; and fatty acid methyl ester at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed. These microorganisms and methods make use of molecular switches to regulate gene expression.Type: ApplicationFiled: January 30, 2018Publication date: February 6, 2020Inventors: Mark Anton HELD, Xinhua ZHAO, Lily Yuin CHAO, Na TRINH, James KEALEY, Kein Lee DIETZEL
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GENETICALLY MODIFIED CELLS AND METHODS FOR CONVERTING (R)-METHYLMALONYL COA TO (S)-METHYLMALONYL COA
Publication number: 20090098615Abstract: Recombinant Escherichia coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases not present in wild-type E. coli host cells.Type: ApplicationFiled: November 5, 2007Publication date: April 16, 2009Inventors: Daniel SANTI, Larry Peck, Linda Dayem, James Kealey -
Genetically modified cells and methods for converting (R)-methylmalonyl CoA to (S)-methylmalonyl CoA
Patent number: 7291486Abstract: Recombinant Escherichia coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases not present in wild-type E. coli host cells.Type: GrantFiled: April 21, 2004Date of Patent: November 6, 2007Assignee: KOSAN Biosciences, Inc.Inventors: Daniel Santi, Linda Dayem, James Kealey -
Patent number: 7011959Abstract: Recombinant E. coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases and is not present in wild-type E. coli host cells.Type: GrantFiled: October 27, 2000Date of Patent: March 14, 2006Assignee: Kosan Biosciences, Inc.Inventors: Daniel Santi, Larry Peck, Linda Dayem, James Kealey
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Publication number: 20040185541Abstract: Recombinant host cells that comprise recombinant DNA expression vectors that drive expression of a product and a precursor for biosynthesis of that product can be used to produce useful products such as polyketides in host cells that do not naturally produce the product or produce the product or precursor at low levels due to the absence of the precursor or the presence of the precursor in rate limiting amounts.Type: ApplicationFiled: April 21, 2004Publication date: September 23, 2004Inventors: Daniel Santi, Linda Dayem, James Kealey
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Publication number: 20020142401Abstract: Recombinant host cells that comprise recombinant DNA expression vectors that drive expression of a product and a precursor for biosynthesis of that product can be used to produce useful products such as polyketides in host cells that do not naturally produce the product or produce the product or precursor at low levels due to the absence of the precursor or the presence of the precursor in rate limiting amounts.Type: ApplicationFiled: August 29, 2001Publication date: October 3, 2002Inventors: Daniel Santi, Linda Dayem, James Kealey