Patents by Inventor James Knott
James Knott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250076297Abstract: Provided herein are materials and methods for in vivo labeling of membrane proteins using plasma-induced modification of biomolecules (PLIMB).Type: ApplicationFiled: August 28, 2024Publication date: March 6, 2025Inventors: Daniel Benjamin, Faraz Choudhury, Jonathan Schmitz, James Dowell, Alexis Lawton, Samantha Knott
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Publication number: 20250076308Abstract: Provided herein are materials and methods for plasma-free labeling of biological molecules with trifluoromethyl and hydroxyl radicals generated using a peroxide and a radical precursor such as sodium triflinate. The methods provided herein find use in labeling of molecules, such as cell-membrane proteins, in live, intact cells.Type: ApplicationFiled: September 6, 2024Publication date: March 6, 2025Inventors: Daniel Benjamin, Faraz Choudhury, Jonathan Schmitz, James Dowell, Alexis Lawton, Samantha Knott, Patric Sadecki
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Publication number: 20200281243Abstract: The present invention relates to dietary product comprising a plurality of amino acids, wherein the dietary product comprises all the essential amino acids and wherein the dietary product is substantially devoid of asparagine, processes of preparation of the product and methods and uses thereof in therapeutic applications such as the treatment of cancer.Type: ApplicationFiled: November 13, 2018Publication date: September 10, 2020Applicant: CANCER RESEARCH TECHNOLOGY LTDInventors: Greg Hannon, Simon James Knott
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Patent number: 8720841Abstract: A clamp assembly including a base member, wherein the base member includes a top surface and a bottom surface, and wherein at least one of the top and bottom surfaces is adapted for fixed or releasable association with a substrate; a first support arm, wherein the first support arm includes an inner surface and an outer surface, and wherein the first support arm is displaceable along a first axis, a second support arm, wherein the second support arm includes an inner surface and an outer surface, and wherein the second support arm is displaceable along the first axis, and wherein the first and second support arms are biased such that the inner surfaces of the support members contact each other at a first contact point.Type: GrantFiled: October 11, 2010Date of Patent: May 13, 2014Inventors: Michael Morren, James Knott, Donald Morren, James Morren
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Publication number: 20110101190Abstract: A clamp assembly including a base member, wherein the base member includes a top surface and a bottom surface, and wherein at least one of the top and bottom surfaces is adapted for fixed or releasable association with a substrate; a first support arm, wherein the first support arm includes an inner surface and an outer surface, and wherein the first support arm is displaceable along a first axis, a second support arm, wherein the second support arm includes an inner surface and an outer surface, and wherein the second support arm is displaceable along the first axis, and wherein the first and second support arms are biased such that the inner surfaces of the support members contact each other at a first contact point.Type: ApplicationFiled: October 11, 2010Publication date: May 5, 2011Inventors: Michael Morren, James Knott, Donald Morren, James Morren
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Patent number: 7416621Abstract: A method is disclosed for rounding and/or flattening an annular part that is out of round and/or not flat due to non-uniform internal stresses. The part is first checked for out of round and/or out of flat conditions. Out of round parts are then rounded by introducing compressive stresses into selected surface sections of the part whereby the introduced compressive stresses cause deformation of the annular part thereby rounding the annular part. Alternatively, out of round parts are rounded by relieving compressive stresses in selected surface sections of the part whereby the relieving of compressive stresses causes deformation of the annular part thereby rounding the annular part. Out of flat parts are flattened by introducing compressive stresses into selected surface sections of the part whereby the introduced compressive stresses cause deformation of the annular part thereby flattening the annular part.Type: GrantFiled: July 22, 2005Date of Patent: August 26, 2008Assignee: GKN Sinter Metals, Inc.Inventor: Henry James Knott
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Publication number: 20070007325Abstract: A carton with a handle opening formed in an end wall includes one or more inserts—each being hingedly connected to a handle panel structure for reinforcing and improving the ergonomics of the handle opening. Each handle panel structure includes a reinforcing portion that reinforces the weight-bearing edge of the handle opening. In certain embodiments, this reinforcing portion is formed by folding the multiple panels of the handle panel structure into a hollow box beam shape with a handle edge that reinforcingly aligns with the weight-bearing edge of the handle opening to provide structural integrity. In certain other embodiments, the reinforcing portion is the outermost edge of the handle panel structure, which similarly aligns to support the integrity of the handle opening. The handle opening is further cushioned and reinforced by a punchout flap that folds inward through the handle opening and wraps around the handle panel structure.Type: ApplicationFiled: September 21, 2005Publication date: January 11, 2007Inventors: Tsugihiko Suzuki, Aaron Bates, James Knotts
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Publication number: 20060261138Abstract: A carton includes a tray (110) and a lid (120). The tray includes a pair of handles (400, 405), each comprising a first panel (370) extending in a first direction, a second panel (350) extending in a second direction, and a third panel (330) extending in a third direction. The lid is removably attached to the tray. The lid is positioned between the pair of handles.Type: ApplicationFiled: May 19, 2006Publication date: November 23, 2006Inventors: Aaron Bates, James Knotts
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Publication number: 20060049388Abstract: A wire mesh sandwich construction which comprises an array of line wires, an array of cross wires overlying said array of line wires and a barrier material disposed between the array of line wires and the array of cross wires. The array of line wires is spaced apart from the array of cross wires to form points of intersection therebetween. The array of line wires is joined to said array of cross wires at the points of intersection and through the barrier material, thus securing the barrier material between the array of line wires and the array of cross wires.Type: ApplicationFiled: August 30, 2004Publication date: March 9, 2006Inventors: James Knott, James Knott
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Patent number: 6876114Abstract: A magnetic flux shield extending substantially the entire width of a magnetic disk drive spindle motor magnet is mounted between the magnet and the disk drive's base frame and rotates with the magnet. The flux shield is formed of a magnetic material to capture any stray magnetic flux from the motor magnet that may produce power draining eddy currents in the base frame.Type: GrantFiled: June 28, 2001Date of Patent: April 5, 2005Assignee: Seagate Technology LLCInventors: Ralph James Knotts, Garry Edward Korbel
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Patent number: 6850388Abstract: Embodiments of the invention generally provide an apparatus and method for, sealing an outer surface of a shaft to an inner surface of a hub. In one embodiment, the invention provides a magnetic fluid seal held in a gap defined by a top member and a bottom member. In one aspect, the distance from the rotational axis of the shaft to the outer periphery of the lower member is less than the distance between the rotational axis of the shaft and the outer periphery of the upper member. In another aspect, the lower member has a member that slopes between a first radial distance to a second radial distance, relative the rotational axis of the shaft. In another aspect, the member has a stepped region including a first and second region where the first stepped region corresponds to a first radial distance, and the second stepped region corresponds to a second radial distance, relative the rotational axis of the shaft.Type: GrantFiled: February 5, 2002Date of Patent: February 1, 2005Assignee: Seagate Technology LLCInventor: Ralph James Knotts
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Publication number: 20040197736Abstract: A polymerisable resin injection moulded denture is manufactured by making a first impression in a stock impression tray and producing a first cast model therefrom, providing a second impression tray special to the patient by forming a thermo plastic resin sheet on the first cast model, the resin sheet being such as to provide stability equivalent at least to that of 0.75 mm of stainless steel sheet, using said second impression tray with suitable adhesive to take a second accurate impression in silicone-free alginate impression material giving set volume stability to within 0.005% and from it making an accurate model die upon which a way replica denture is constructed and a mould thereof is produced of dental gypsum in a special flask which during injection moulding is subjected to progressive adjustment of clamping pressure between mould halves with rising injection pressure.Type: ApplicationFiled: March 19, 2004Publication date: October 7, 2004Inventor: Nigel James Knott
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Patent number: 6742253Abstract: A presently-preferred process for manufacturing a connecting rod comprises placing a heated preform suitable for being formed into the connecting rod into a closed forge die, and forging the preform in a first forging operation while the preform is at a forging temperature to form an as-forged connecting rod having vertical flash extending therefrom. The presently-preferred process further comprises placing the as-forged connecting rod in a second forge die while the as-forged connecting rod is at a temperature substantially equal to the forging temperature, and forging the vertical flash in a second forging operation. The presently-preferred process also comprises removing the as-forged connecting rod from the second forge die, and machining the as-forged connecting rod to predetermined dimensions.Type: GrantFiled: June 29, 2001Date of Patent: June 1, 2004Assignee: GKN Sinter MetalsInventors: Timothy E. Geiman, Ronald Lee Trosin, Henry James Knott
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Publication number: 20030000087Abstract: A presently-preferred process for manufacturing a connecting rod comprises placing a heated preform suitable for being formed into the connecting rod into a closed forge die, and forging the preform in a first forging operation while the preform is at a forging temperature to form an as-forged connecting rod having vertical flash extending therefrom. The presently-preferred process further comprises placing the as-forged connecting rod in a second forge die while the as-forged connecting rod is at a temperature substantially equal to the forging temperature, and forging the vertical flash in a second forging operation. The presently-preferred process also comprises removing the as-forged connecting rod from the second forge die, and machining the as-forged connecting rod to predetermined dimensions.Type: ApplicationFiled: June 29, 2001Publication date: January 2, 2003Inventors: Timothy E. Geiman, Ronald Lee Trosin, Henry James Knott
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Publication number: 20020070616Abstract: A motor comprises a shaft supported from a base frame and supporting a hub and one or more on the outer diameter thereof. A stator is supported from the shaft, and comprises a plurality of laminations supporting coils which are sequentially energized to cause rotation of a hub which overlies the stator and supports a magnet and back iron radially adjacent these stator coils. A shield is provided extending substantially the entire width of the magnet and intervening between the magnet and the base frame and rotating with the magnet. The flux shield is formed of a magnetic material to capture any stray magnetic flux from the motor magnet.Type: ApplicationFiled: June 28, 2001Publication date: June 13, 2002Inventors: Ralph James Knotts, Garry Edward Korbel