Abstract: The present invention provides stable, pure and potent compositions optimized for administration to neonates and/or preterm infants, and use of the same in methods for treating intraventricular hemorrhage (IVH), bronchopulmonary dysplasia (BPD), and/or chronic lung disease of prematurity (CLD), comprising administering to a subject in need of treatment a pharmaceutical composition comprising insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3), and a polysorbate 20 surfactant at high effective doses in low volumes in an infant resulting high serum IGF-1 exposure and treatment of IVH, BPD and/or CLD. In some aspects, provided herein are methods for manufacturing the compositions comprising a single-use bag, wherein the compositions have improved stability, reduced oxidation and increased potency.

Abstract: The present disclosure relates to pharmaceutical compositions of anti-CD40 antibodies, such as humanized anti-CD40 antibodies. The pharmaceutical compositions may be used in various therapeutic, prophylactic and diagnostic methods. The antibodies block the ability of CD40 to bind CD154 without activating the cell expressing CD40 (e.g., a B cell).

Abstract: The present disclosure features a pharmaceutical formulation containing an anti-CD40 antibody, KPL-404.

Abstract: The present disclosure relates to dosing regimens of pharmaceutical compositions of anti-CD40 antibodies, such as humanized anti-CD40 antibodies, and uses thereof in the treatment of rheumatoid arthritis.

Abstract: Techniques and systems for enhancing vertical edges during photopolymer-based three-dimensional (3D) printing are described.

Abstract: Techniques and systems for enhancing vertical edges during photopolymer-based three-dimensional (3D) printing are described.

Abstract: The invention is directed to a method for producing a polypeptide composition comprising: combining a polypeptide with a volatile additive to form a liquid mixture and lyophilizing the liquid mixture to obtain a lyophilized polypeptide composition.

Abstract: Techniques and systems for enhancing vertical edges during photopolymer-based three-dimensional (3D) printing are described.

Abstract: A cloud computing system includes a plurality of tenants that are permitted to access cloud hosted applications. The system includes an input governance layer associated with each application, and an output governance layer associated with each application. The input governance layer and the output governance layer include an encapsulation of a cloud hosted application. The governance layers receive a request from a tenant-user to access a first application on the cloud computing system, check a governance database to determine if the tenant-user is authorized to access the first application, and allows or denies access accordingly.

Abstract: A system, method, apparatus and computer program product is described to provide a plurality of connectors, the connectors configured to support one or more applications in at least one configuration selected from a group of configurations including: i) a non-tenant, and non-tenant aware, application, ii) a non-tenant, but tenant aware, application, iii) a many tenant application, iv) a multi-tenant application, and v) a native multi-tenant application. Also provided are one or more application programming interfaces (APIs) to the connectors, the one or more APIs providing a substantially uniform interface to applications supported by the connectors. In one embodiment, a governance layer provides the APIs, and the governance layer communicates with the connectors, so that an application's tenancy support is obfuscated.

Abstract: A cloud computing system includes a plurality of tenants that are permitted to access cloud hosted applications. The system includes an input governance layer associated with each application, and an output governance layer associated with each application. The input governance layer and the output governance layer include an encapsulation of a cloud hosted application. The governance layers receive a request from a tenant-user to access a first application on the cloud computing system, check a governance database to determine if the tenant-user is authorized to access the first application, and allows or denies access accordingly.

Abstract: A cloud computing system includes a plurality of tenants that are permitted to access cloud hosted applications. The system includes an input governance layer associated with each application, and an output governance layer associated with each application. The input governance layer and the output governance layer include an encapsulation of a cloud hosted application. The governance layers receive a request from a tenant-user to access a first application on the cloud computing system, check a governance database to determine if the tenant-user is authorized to access the first application, and allows or denies access accordingly.

Abstract: A system, method, apparatus and computer program product is described to provide a plurality of connectors, the connectors configured to support one or more applications in at least one configuration selected from a group of configurations including: i) a non-tenant, and non-tenant aware, application, ii) a non-tenant, but tenant aware, application, iii) a many tenant application, iv) a multi-tenant application, and v) a native multi-tenant application. Also provided are one or more application programming interfaces (APIs) to the connectors, the one or more APIs providing a substantially uniform interface to applications supported by the connectors. In one embodiment, a governance layer provides the APIs, and the governance layer communicates with the connectors, so that an application's tenancy support is obfuscated.

Abstract: A cloud computing system includes a plurality of tenants that are permitted to access cloud hosted applications. The system includes an input governance layer associated with each application, and an output governance layer associated with each application. The input governance layer and the output governance layer include an encapsulation of a cloud hosted application. The governance layers receive a request from a tenant-user to access a first application on the cloud computing system, check a governance database to determine if the tenant-user is authorized to access the first application, and allows or denies access accordingly.

Abstract: The invention is directed to a method for producing a polypeptide composition comprising: combining a polypeptide with a volatile additive to form a liquid mixture and lyophilizing the liquid mixture to obtain a lyophilized polypeptide composition.