Patents by Inventor James Krom

James Krom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210161672
    Abstract: An injury or defect in articular cartilage is treated with a matrix implant that is applied above a barrier composition. The polymer-containing barrier composition is applied to the bottom of a cartilage lesion. The barrier composition can block migration of cells, blood, or other material from subchondral bone into the cartilage lesion.
    Type: Application
    Filed: June 10, 2019
    Publication date: June 3, 2021
    Applicant: HISTOGENICS CORPORATION
    Inventor: James KROM
  • Patent number: 10022469
    Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: July 17, 2018
    Assignee: Biosphere Medical, SA
    Inventors: Philippe Reb, Marion Pierre, Barbara De Gioannis, James Krom
  • Publication number: 20160361458
    Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.
    Type: Application
    Filed: August 26, 2016
    Publication date: December 15, 2016
    Inventors: Philippe Reb, Marion Pierre, Barbara De Gioannis, James Krom
  • Patent number: 9439861
    Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: September 13, 2016
    Assignee: Biosphere Medical, SA
    Inventors: Philippe Reb, Marion Pierre, Barbara De Gioannis, James Krom
  • Publication number: 20130252900
    Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.
    Type: Application
    Filed: May 8, 2013
    Publication date: September 26, 2013
    Applicant: Biosphere Medical, SA
    Inventors: Philippe Reb, Marion Pierre, Barbara De Gioannis, James Krom
  • Patent number: 8057899
    Abstract: A nano-particle composition including a poly(alkenylbenzene) core and a poly (conjugated diene) or a poly(alkylene) surface layer is provided. The nano-particles have a mean average diameter less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can advantageously be incorporated into rubbers, elastomers, and thermoplastics.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: November 15, 2011
    Assignee: Bridgestone Corporation
    Inventors: Xiaorong Wang, Chenchy Jeffrey Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
  • Publication number: 20110182998
    Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.
    Type: Application
    Filed: January 26, 2011
    Publication date: July 28, 2011
    Applicants: Biosphere Medical, Inc., BioSphere Medical, SA
    Inventors: Philippe Reb, Pierre Marion, Barbara De Gioannis, James Krom
  • Patent number: 7795344
    Abstract: A nano-particle composition including a poly(alkenylbenzene) core and a poly(conjugated diene), a poly(alkylene), or a poly(alkenylbenzene) surface layer is provided. The nano-particles have a mean average diameter of less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can be advantageously be incorporated into rubbers, elastomers, and thermoplastics.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: September 14, 2010
    Assignee: Bridgestone Corporation
    Inventors: Xiaorong Wang, Chenchy Jeffrey Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
  • Publication number: 20090048390
    Abstract: A nano-particle composition including a poly(alkenylbenzene) core and a poly(conjugated diene), a poly(alkylene), or a poly(alkenylbenzene) surface layer is provided. The nano-particles have a mean average diameter of less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can be advantageously be incorporated into rubbers, elastomers, and thermoplastics.
    Type: Application
    Filed: November 16, 2007
    Publication date: February 19, 2009
    Inventors: Xiaorong Wang, Chenchy Jeffrey Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
  • Publication number: 20070027264
    Abstract: Abstract of the Disclosure A multi-layer nano-particle composition including a polymer core and at least two additional layers is provided. The nano-particles have a mean average diameter less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can be advantageously incorporated into rubbers, elastomers, and thermoplastics.
    Type: Application
    Filed: June 29, 2005
    Publication date: February 1, 2007
    Applicant: Bridgestone Corporation
    Inventors: Xiaorong Wang, Victor Foltz, James Krom
  • Publication number: 20060084722
    Abstract: A polymer nano-particle composition is provided, wherein the nano-particle includes a poly(alkenylbenzene) core and a surface layer including poly(conjugated diene). A method for self-assembly of the nano-particles is also provided. The polymer nano-particles are preferably less than about 100 nm in diameter.
    Type: Application
    Filed: April 29, 2005
    Publication date: April 20, 2006
    Inventors: Georg Bohm, Xiaorong Wang, Chenchy Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
  • Publication number: 20060067883
    Abstract: One aspect of the present invention relates to a microsphere, comprising a hydrophilic polymer comprising a plurality of pendant anionic groups; a transition-metal, lanthanide or group 13-14 metal oxide, polyoxometalate or metal hydroxide or combination thereof; and a first radioisotope that emits a therapeutic ?-particle. In certain embodiments, the microsphere further comprsies a second radioisotope that emits a diagnostic ?-ray; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In certain embodiments, the microsphere is composed of polymer impregnated with zirconia bound to 32p as the source of the therapeutic ?-emissions and 67Ga as the source of the diagnostic ?-emissions.
    Type: Application
    Filed: July 19, 2005
    Publication date: March 30, 2006
    Applicant: Biosphere Medical, Inc.
    Inventors: James Krom, Alexander Schwarz
  • Publication number: 20060036031
    Abstract: A reaction product is prepared by reacting a first polymer having pendant or terminal carboxyl or anhydride groups with a second polymer (e.g. elastomer) having an amine containing terminal group. The second polymer is anionically polymerized. The second polymer is functionalized by reacting the growing anionic chain end with an imine. Then a protic terminating agent terminates the growing chain end. The first and second polymers are reacted by mixing (desirably above their softening temperatures) and forming a blend with improved physical properties over a blend of similar polymers lacking a reactive amine group.
    Type: Application
    Filed: August 17, 2005
    Publication date: February 16, 2006
    Inventors: James Krom, Xiaorong Wang
  • Patent number: 6956084
    Abstract: A nano-particle composition including a poly (alkenylbenzene) core and a poly (conjugated diene) or a poly(alkylene) surface layer is provided. The nano-particles have a mean average diameter less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can advantageously be incorporated into rubbers, elastomers, and thermoplastics.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: October 18, 2005
    Assignee: Bridgestone Corporation
    Inventors: Xiaorong Wang, Chenchy Jeffrey Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
  • Publication number: 20050192408
    Abstract: A nano-particle composition including a poly(alkenylbenzene) core and a poly (conjugated diene) or a poly(alkylene) surface layer is provided. The nano-particles have a mean average diameter less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can advantageously be incorporated into rubbers, elastomers, and thermoplastics.
    Type: Application
    Filed: April 13, 2005
    Publication date: September 1, 2005
    Inventors: Xiaorong Wang, Chenchy Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
  • Publication number: 20030198810
    Abstract: A nano-particle composition including a poly (alkenylbenzene) core and a poly (conjugated diene) or a poly(alkylene) surface layer is provided. The nano-particles have a mean average diameter less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can advantageously be incorporated into rubbers, elastomers, and thermoplastics.
    Type: Application
    Filed: August 19, 2002
    Publication date: October 23, 2003
    Inventors: Xiaorong Wang, Chenchy Jeffrey Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
  • Patent number: 6437050
    Abstract: A polymer nano-particle composition is provided, wherein the nano-particle includes a poly(alkenylbenzene) core and a surface layer including poly(conjugated diene). The polymer nano-particles are preferably less than about 100 nm in diameter. The nano-particles can be made by a dispersion polymerization process.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: August 20, 2002
    Assignee: Bridgestone Corporation
    Inventors: James Krom, Xiaorong Wang