Patents by Inventor James Krom
James Krom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210161672Abstract: An injury or defect in articular cartilage is treated with a matrix implant that is applied above a barrier composition. The polymer-containing barrier composition is applied to the bottom of a cartilage lesion. The barrier composition can block migration of cells, blood, or other material from subchondral bone into the cartilage lesion.Type: ApplicationFiled: June 10, 2019Publication date: June 3, 2021Applicant: HISTOGENICS CORPORATIONInventor: James KROM
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Patent number: 10022469Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.Type: GrantFiled: August 26, 2016Date of Patent: July 17, 2018Assignee: Biosphere Medical, SAInventors: Philippe Reb, Marion Pierre, Barbara De Gioannis, James Krom
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Publication number: 20160361458Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.Type: ApplicationFiled: August 26, 2016Publication date: December 15, 2016Inventors: Philippe Reb, Marion Pierre, Barbara De Gioannis, James Krom
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Patent number: 9439861Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.Type: GrantFiled: May 8, 2013Date of Patent: September 13, 2016Assignee: Biosphere Medical, SAInventors: Philippe Reb, Marion Pierre, Barbara De Gioannis, James Krom
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Publication number: 20130252900Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.Type: ApplicationFiled: May 8, 2013Publication date: September 26, 2013Applicant: Biosphere Medical, SAInventors: Philippe Reb, Marion Pierre, Barbara De Gioannis, James Krom
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Patent number: 8057899Abstract: A nano-particle composition including a poly(alkenylbenzene) core and a poly (conjugated diene) or a poly(alkylene) surface layer is provided. The nano-particles have a mean average diameter less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can advantageously be incorporated into rubbers, elastomers, and thermoplastics.Type: GrantFiled: April 13, 2005Date of Patent: November 15, 2011Assignee: Bridgestone CorporationInventors: Xiaorong Wang, Chenchy Jeffrey Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
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Publication number: 20110182998Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.Type: ApplicationFiled: January 26, 2011Publication date: July 28, 2011Applicants: Biosphere Medical, Inc., BioSphere Medical, SAInventors: Philippe Reb, Pierre Marion, Barbara De Gioannis, James Krom
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Patent number: 7795344Abstract: A nano-particle composition including a poly(alkenylbenzene) core and a poly(conjugated diene), a poly(alkylene), or a poly(alkenylbenzene) surface layer is provided. The nano-particles have a mean average diameter of less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can be advantageously be incorporated into rubbers, elastomers, and thermoplastics.Type: GrantFiled: November 16, 2007Date of Patent: September 14, 2010Assignee: Bridgestone CorporationInventors: Xiaorong Wang, Chenchy Jeffrey Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
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Publication number: 20090048390Abstract: A nano-particle composition including a poly(alkenylbenzene) core and a poly(conjugated diene), a poly(alkylene), or a poly(alkenylbenzene) surface layer is provided. The nano-particles have a mean average diameter of less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can be advantageously be incorporated into rubbers, elastomers, and thermoplastics.Type: ApplicationFiled: November 16, 2007Publication date: February 19, 2009Inventors: Xiaorong Wang, Chenchy Jeffrey Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
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Publication number: 20070027264Abstract: Abstract of the Disclosure A multi-layer nano-particle composition including a polymer core and at least two additional layers is provided. The nano-particles have a mean average diameter less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can be advantageously incorporated into rubbers, elastomers, and thermoplastics.Type: ApplicationFiled: June 29, 2005Publication date: February 1, 2007Applicant: Bridgestone CorporationInventors: Xiaorong Wang, Victor Foltz, James Krom
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Publication number: 20060084722Abstract: A polymer nano-particle composition is provided, wherein the nano-particle includes a poly(alkenylbenzene) core and a surface layer including poly(conjugated diene). A method for self-assembly of the nano-particles is also provided. The polymer nano-particles are preferably less than about 100 nm in diameter.Type: ApplicationFiled: April 29, 2005Publication date: April 20, 2006Inventors: Georg Bohm, Xiaorong Wang, Chenchy Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
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Publication number: 20060067883Abstract: One aspect of the present invention relates to a microsphere, comprising a hydrophilic polymer comprising a plurality of pendant anionic groups; a transition-metal, lanthanide or group 13-14 metal oxide, polyoxometalate or metal hydroxide or combination thereof; and a first radioisotope that emits a therapeutic ?-particle. In certain embodiments, the microsphere further comprsies a second radioisotope that emits a diagnostic ?-ray; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In certain embodiments, the microsphere is composed of polymer impregnated with zirconia bound to 32p as the source of the therapeutic ?-emissions and 67Ga as the source of the diagnostic ?-emissions.Type: ApplicationFiled: July 19, 2005Publication date: March 30, 2006Applicant: Biosphere Medical, Inc.Inventors: James Krom, Alexander Schwarz
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Publication number: 20060036031Abstract: A reaction product is prepared by reacting a first polymer having pendant or terminal carboxyl or anhydride groups with a second polymer (e.g. elastomer) having an amine containing terminal group. The second polymer is anionically polymerized. The second polymer is functionalized by reacting the growing anionic chain end with an imine. Then a protic terminating agent terminates the growing chain end. The first and second polymers are reacted by mixing (desirably above their softening temperatures) and forming a blend with improved physical properties over a blend of similar polymers lacking a reactive amine group.Type: ApplicationFiled: August 17, 2005Publication date: February 16, 2006Inventors: James Krom, Xiaorong Wang
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Patent number: 6956084Abstract: A nano-particle composition including a poly (alkenylbenzene) core and a poly (conjugated diene) or a poly(alkylene) surface layer is provided. The nano-particles have a mean average diameter less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can advantageously be incorporated into rubbers, elastomers, and thermoplastics.Type: GrantFiled: August 19, 2002Date of Patent: October 18, 2005Assignee: Bridgestone CorporationInventors: Xiaorong Wang, Chenchy Jeffrey Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
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Publication number: 20050192408Abstract: A nano-particle composition including a poly(alkenylbenzene) core and a poly (conjugated diene) or a poly(alkylene) surface layer is provided. The nano-particles have a mean average diameter less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can advantageously be incorporated into rubbers, elastomers, and thermoplastics.Type: ApplicationFiled: April 13, 2005Publication date: September 1, 2005Inventors: Xiaorong Wang, Chenchy Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
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Publication number: 20030198810Abstract: A nano-particle composition including a poly (alkenylbenzene) core and a poly (conjugated diene) or a poly(alkylene) surface layer is provided. The nano-particles have a mean average diameter less than about 100 nm. The nano-particles can be modified via, for example, hydrogenation or functionalization. The nano-particles can advantageously be incorporated into rubbers, elastomers, and thermoplastics.Type: ApplicationFiled: August 19, 2002Publication date: October 23, 2003Inventors: Xiaorong Wang, Chenchy Jeffrey Lin, James Hall, Sandra Warren, James Krom, Hajime Kondo, Koichi Morita
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Patent number: 6437050Abstract: A polymer nano-particle composition is provided, wherein the nano-particle includes a poly(alkenylbenzene) core and a surface layer including poly(conjugated diene). The polymer nano-particles are preferably less than about 100 nm in diameter. The nano-particles can be made by a dispersion polymerization process.Type: GrantFiled: October 4, 2001Date of Patent: August 20, 2002Assignee: Bridgestone CorporationInventors: James Krom, Xiaorong Wang