Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

Abstract: Systems and methods for joint document signing are described. According to one aspect, a method for joint document signing includes establishing a live communication session including a plurality of users. In some cases, the plurality of users correspond to a set of signers of a document. The method further includes initiating a signing process during the live communication session, receiving a signature for the document from each of the plurality of users during the live communication session based on the signing process, and generating a signed document including the signature from each of the plurality of users.

Abstract: An autonomous vehicle includes an autonomously driven vehicle frame with a retractable pivot mechanism disposed on a platform surface of the vehicle frame. Changeable utility pods are configured to attach to and be removed from the vehicle frame by way of the retractable pivot mechanism onboard the frame, and autonomously change the vehicle from a passenger transport to a logistics transport by changing utility pods. A processor provides autonomous vehicle operations that include extending the retractable pivot mechanism from a retracted position recessed in the platform surface of the vehicle frame to an extended position that engages a utility pod conveyor channel. The retractable pivot mechanism engages a conveyor channel disposed on a mating surface of a utility pod, and conveys the utility pod along the conveyor channel to a centered and laterally-aligned position on the vehicle frame by rotating the pod into position once centered over the pivot mechanism.

Abstract: An autonomous vehicle includes an autonomously driven vehicle frame with a retractable pivot mechanism disposed on a platform surface of the vehicle frame. Changeable utility pods are configured to attach to and be removed from the vehicle frame by way of the retractable pivot mechanism onboard the frame, and autonomously change the vehicle from a passenger transport to a logistics transport by changing utility pods. A processor provides autonomous vehicle operations that include extending the retractable pivot mechanism from a retracted position recessed in the platform surface of the vehicle frame to an extended position that engages a utility pod conveyor channel. The retractable pivot mechanism engages a conveyor channel disposed on a mating surface of a utility pod, and conveys the utility pod along the conveyor channel to a centered and laterally-aligned position on the vehicle frame by rotating the pod into position once centered over the pivot mechanism.

Abstract: A process and system is provided for removing total heat from a base load LNG liquefaction facility by using a hybrid cooling process. After liquefying a gas such as natural gas with a refrigerant, the refrigerant is transferred to a compression unit. In order to condense the compressed refrigerant, the refrigerant first flows through process coil bundles. As the refrigerant flows through the process coil bundles, water is sprayed, via a spray distribution system and a water reservoir, onto the outer surface of the process coil bundles. Air is passed over the process coil bundles via a fan system to allow heat transfer to take place and to cool and condense the refrigerant.

Abstract: A vehicle having a running board provided substantially beneath a vehicle door, which is accessible when the vehicle door is in an open orientation is disclosed.

Abstract: A door assembly is provided having an ergonomic egress handle. The egress handle includes a door release lever that is pivotally connected to an automotive vehicle door about an axis that is generally perpendicular to the door for unlatching the door so that the door may be opened relative to the vehicle. A method is also provided for operation of the door assembly.

Abstract: A door assembly is provided having an ergonomic egress handle. The egress handle includes a door release lever that is pivotally connected to an automotive vehicle door about an axis that is generally perpendicular to the door for unlatching the door so that the door may be opened relative to the vehicle. A method is also provided for operation of the door assembly.