Patents by Inventor James L. Bergey

James L. Bergey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preventing, stabilizing or causing regression of atherosclerosis employing a combination of a cholesterol lowering drug and an ace inhibitor
    Patent number: 6630502
    Abstract: A method is provided for slowing the progression of atherosclerosis in hypertensive or normotensive patients and reducing or eliminating atherosclerotic lesions in such patients by administering a combination of a cholesterol lowering drug such as pravastatin, and an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.
    Type: Grant
    Filed: December 2, 1991
    Date of Patent: October 7, 2003
    Assignee: E.R. Squibb & Sons, Inc.
    Inventors: James L. Bergey, Werner Tschollar, Cary S. Yonce, James C. Kawano
  • METHOD FOR PREVENTING, STABILIZING OR CAUSING REGRESSION OF ATHEROSCLEROSIS EMPLOYING A COMBINATION OF A CHOLESTEROL LOWERING DRUG AND AN ACE INHIBITOR
    Publication number: 20030149101
    Abstract: A method is provided for slowing the progression of atherosclerosis in hypertensive or normotensive patients and reducing or eliminating atherosclerotic lesions in such patients by administering a combination of a cholesterol lowering drug such as pravastatin, and an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.
    Type: Application
    Filed: December 2, 1991
    Publication date: August 7, 2003
    Inventors: JAMES L. BERGEY, WERNER TSCHOLLAR, CARY S. YONCE, JAMES C. KAWANO
  • Method for preventing onset of hypertension employing a cholesterol lowering drug
    Patent number: 5593971
    Abstract: A method is provided for preventing or reducing the risk of hypertension in normotensive patients having insulin resistance by administering a cholesterol lowering drug, such as pravastatin, alone or in combination with an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: January 14, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Werner Tschollar, Cary S. Yonce, James L. Bergey, James C. Kawano
  • Method for treating hypertension employing a cholesterol lowering drug
    Patent number: 5461039
    Abstract: A method is provided for treating hypertension in normotensive patients having insulin resistance by administering a cholesterol lowering drug, such as pravastatin, alone or in combination with an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: October 24, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Werner Tschollar, Cary S. Yonce, James L. Bergey, James C. Kawano
  • Method for preventing onset of hypertension employing a cholesterol lowering drug
    Patent number: 5298497
    Abstract: A method is provided for preventing or reducing the risk of hypertension in normotensive patients having insulin resistance by administering a cholesterol lowering drug, such as pravastatin, alone or in combination with an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.
    Type: Grant
    Filed: June 1, 1992
    Date of Patent: March 29, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Werner Tschollar, Cary S. Yonce, James L. Bergey, James C. Kawano
  • Pharmaceutical composition and method for treating cardiovascular diseases using substituted anilides and sulfonamides
    Patent number: 5116851
    Abstract: A novel pharmaceutical composition and method is disclosed for the treatment of cardiovascular diseases, e.g. myocardial ischemia and/or arrhythmia. The method and composition include an effective amount of a compound of the formula ##STR1## wherein X, Y, R, R.sub.1, A, A', m, n, p, p' and B are as defined herein.
    Type: Grant
    Filed: January 26, 1990
    Date of Patent: May 26, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John Krapcho, James L. Bergey, Gary J. Grover
  • Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation
    Patent number: 5008284
    Abstract: Zofenopril, fosinopril, (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-pro line or a pharmaceutically acceptable salt thereof alone or in combination with a thrombolytic, antiarrhythmic, or antifibrillatory agent is employed to reduce pre- and post-ischemic myocardial arrhythmias and fibrillations as well as reducing arrhythmias associated with congestive heart failure.
    Type: Grant
    Filed: December 18, 1989
    Date of Patent: April 16, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gary J. Grover, James L. Bergey
  • Method of reducing pre-and post-ischemic myocardial arrhythmias and fibrillation
    Patent number: 4962095
    Abstract: Zofenopril, fosinopril, (S)-1-[6-amino-2-[[hydroxy (4-phenylbutyl) phosphinyl]oxy]-1-oxohexyl]-L-proline or a pharmaceutically acceptable salt thereof alone or in combination with a thrombolytic, antiarrhythmic, or antifibrillatory agent is employed to reduce pre-and post- ischemic myocardial arrhythmias and fibrillations as well as reducing arrhythmias associated with congestive heart failure.
    Type: Grant
    Filed: December 18, 1989
    Date of Patent: October 9, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gary J. Grover, James L. Bergey
  • Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation
    Patent number: 4931464
    Abstract: Zofenopril, fosinopril, (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-oxohexyl]-L-proli ne or a pharmaceutically acceptable salt thereof alone or in combination with a thrombolytic, antiarrhythmic, or antifibrillatory agent is employed to reduce pre- and post- ischemic myocardial arrhythmias and fibrillations as well as reducing arrhythmias associated with congestive heart failure.
    Type: Grant
    Filed: February 15, 1989
    Date of Patent: June 5, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gary J. Grover, James L. Bergey
  • N-3-Propenylaminopropyl-N'-phenylureas
    Patent number: 4474707
    Abstract: Compounds of the formula: ##STR1## wherein: Y is 2,6-dimethylphenyl, 2,5-dimethylphenyl, 5-bromo-2-methylphenyl, or 5-chloro-2-methylphenyl; andX is propenyl, propynyl, or cyclopropyl; or a non-toxic, pharmaceutically acceptable acid addition salt thereof; possess anti-arrhythmic activity.
    Type: Grant
    Filed: August 26, 1981
    Date of Patent: October 2, 1984
    Assignee: American Home Products Corporation
    Inventors: Theodore S. Sulkowski, James L. Bergey, Albert A. Mascitti
  • Antihypertensive agents
    Patent number: 4365063
    Abstract: 1,4,5,6,7,8-Hexahydro-2-alkyl-4-pentafluorophenyl-5-oxo-1,7-naphthyridine-3 -carboxylic acid esters and pharmaceutically acceptable salts thereof are useful antihypertensive agents.
    Type: Grant
    Filed: August 31, 1981
    Date of Patent: December 21, 1982
    Assignee: American Home Products Corporation
    Inventors: Theodore S. Sulkowski, James L. Bergey, Albert A. Mascitti
  • Anti-arrhythmic N-[3-alkylaminopropyl]-N'-phenylureas
    Patent number: 4348413
    Abstract: Compounds of the formula: ##STR1## wherein: Y is 2,6-dimethylphenyl, 2,5-dimethylphenyl, [5-bromo-2-methylphenyl], or 5-chloro-2-methylphenyl; andX is propyl, isopropyl, n-butyl, or isobutyl; or a non-toxic, pharmaceutically acceptable acid addition salt thereof; possess anti-arrhythmic activity.
    Type: Grant
    Filed: September 22, 1980
    Date of Patent: September 7, 1982
    Assignee: American Home Products Corporation
    Inventors: Theodore S. Sulkowski, James L. Bergey, Albert A. Mascitti
  • Antihypertensive agents
    Patent number: 4321384
    Abstract: 1,4,5,6,7,8-hexahydro-2-alkyl-4-aryl-5-oxo-1,7-naphthyridine-3-carboxylic acid esters and pharmaceutically acceptable salts thereof are useful antihypertensive agents.
    Type: Grant
    Filed: February 27, 1981
    Date of Patent: March 23, 1982
    Assignee: American Home Products Corporation
    Inventors: Theodore S. Sulkowski, James L. Bergey, Albert A. Mascitti
  • Method of suppressing cardiac arrhythmias
    Patent number: 4297373
    Abstract: Method of suppressing cardiac arrhythmias compounds of the formula: ##STR1## wherein: Y is 2,6-dimethylphenyl, 2,5-dimethylphenyl, 5-bromo-2-methylphenyl, or 5-chloro-2-methylphenyl; andX is propenyl, propynyl, or cyclopropyl; or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: October 9, 1980
    Date of Patent: October 27, 1981
    Assignee: American Home Products Corporation
    Inventors: Theodore S. Sulkowski, James L. Bergey, Albert A. Mascitti
  • N-[3-(lower)alkylaminopropyl]-N'-(disubstituted)phenylureas
    Patent number: 4224242
    Abstract: Compounds of the formula: ##STR1## wherein: Y is 2,6-dimethylphenyl, 2,5-dimethylphenyl, 3,5-dimethylphenyl, 2-chloro-6-methylphenyl, or 5-chloro-2-methylphenyl; andX is methyl, ethyl, propyl, isopropyl, n-butyl, or isobutyl;or a non-toxic, pharmaceutically acceptable acid addition salt thereof; possess anti-arrhythmic activity.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: September 23, 1980
    Assignee: American Home Products Corporation
    Inventors: Theodore S. Sulkowski, James L. Bergey, Albert A. Mascitti