Patents by Inventor James L. Diebold

James L. Diebold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multicyclic compounds and the use thereof
    Patent number: 8716493
    Abstract: The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: May 6, 2014
    Assignee: Cephalon, Inc.
    Inventors: Sankar Chatterjee, Reddeppa reddy Dandu, James L. Diebold, Derek D. Dunn, Robert L. Hudkins, Gregory J. Wells, Allison L. Zulli
  • Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-MET inhibitors
    Patent number: 8552186
    Abstract: The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: October 8, 2013
    Assignee: Cephalon, Inc.
    Inventors: Gulzar Ahmed, Henry J. Breslin, Jason Burke, Matthew A. Curry, James L. Diebold, Bruce D. Dorsey, Benjamin J. Dugan, Daming Feng, Diane E. Gingrich, Tao Guo, Keith S. Learn, Joseph Lisko, Rong-qiang Liu, Eugen F. Mesaros, Karen L. Milkiewicz, Gregory R. Ott, Jay P. Theroff, Tho Thieu, Rabindranath Tripathy, Theodore L. Underiner, Gregory J. Wells, Craig A. Zificsak
  • Pyrrolotriazines as ALK and JAK2 inhibitors
    Patent number: 8471005
    Abstract: The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: June 25, 2013
    Assignee: Cephalon, Inc.
    Inventors: Henry J. Breslin, Sankar Chatterjee, James L. Diebold, Bruce D. Dorsey, Derek D. Dunn, Diane E. Gingrich, Greg A. Hostetler, Robert L. Hudkins, Rachael Hunter, Kurt A. Josef, Joseph Lisko, Eugen F. Mesaros, Karen L. Milkiewicz, Gregory R. Ott, Babu G. Sundar, Jay P. Theroff, Tho Thieu, Rabindranath Tripathy, Theodore L. Underiner, Linda Weinberg, Gregory J. Wells, Craig A. Zificsak
  • Fused pyrrolocarbazoles
    Patent number: 8383813
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: February 26, 2013
    Assignee: Cephalon, Inc.
    Inventors: Nadine C. Becknell, Peter D. Brown, Reddeppareddy Dandu, James L. Diebold, Diane E. Gingrich, Robert L. Hudkins, Bruce A. Ruggeri, Ming Tao, Theodore L. Underiner, Allison L. Zulli
  • Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors
    Publication number: 20120165519
    Abstract: The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
    Type: Application
    Filed: March 6, 2012
    Publication date: June 28, 2012
    Applicant: Cephalon, Inc.
    Inventors: Gulzar Ahmed, Henry Joseph Breslin, Jason Burke, Matthew A. Curry, James L. Diebold, Bruce Dorsey, Benjamin J. Dugan, Daming Feng, Diane E. Gingrich, Tao Guo, Keith S. Learn, Joseph G. Lisko, Rong-qiang Liu, Eugen Mesaros, Karen Milkiewicz, Gregory R. Ott, Jay P. Theroff, Tho V. Thieu, Rabindranath Tripathy, Theodore L. Underiner, Gregory J. Wells, Craig A. Zificsak
  • Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors
    Patent number: 8148391
    Abstract: The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: April 3, 2012
    Assignee: Cephalon, Inc.
    Inventors: Gulzar Ahmed, Henry Joseph Breslin, Jason Burke, Matthew A. Curry, James L. Diebold, Bruce Dorsey, Benjamin J. Dugan, Daming Feng, Diane E. Gingrich, Tao Guo, Keith S. Learn, Joseph G. Lisko, Rong-Qiang Liu, Eugen Florin Mesaros, Karen Milkiewicz, Gregory R. Ott, Jay P. Theroff, Tho V. Thieu, Rabindranath Tripathy, Theodore L. Underiner, Gregory J. Wells, Craig A. Zificsak
  • PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS
    Publication number: 20120028919
    Abstract: The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
    Type: Application
    Filed: June 15, 2011
    Publication date: February 2, 2012
    Applicant: CEPHALON, INC.
    Inventors: Henry J. Breslin, Sankar Chatterjee, James L. Diebold, Bruce D. Dorsey, Derek D. Dunn, Diane E. Gingrich, Greg A. Hostetler, Robert L. Hudkins, Rachael Hunter, Kurt A. Josef, Joseph Lisko, Eugen F. Mesaros, Karen L. Milkiewicz, Gregory R. Ott, Babu G. Sundar, Jay P. Theroff, Tho Thieu, Rabindranath Tripathy, Theodore L. Underiner, Linda Weinberg, Gregory J. Wells, Craig A. Zificsak
  • Novel Fused Pyrrolocarbazoles
    Publication number: 20120004253
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Application
    Filed: September 16, 2011
    Publication date: January 5, 2012
    Applicant: CEPHALON, INC.
    Inventors: Nadine C. Becknell, Peter D. Brown, James L. Diebold, Diane E. Gingrich, Robert L. Hudkins, Reddeppareddy Dandu, Bruce A. Ruggeri, Ming Tao, Theodore L. Underiner, Allison L. Zulli
  • NOVEL MULTICYCLIC COMPOUNDS AND THE USE THEREOF
    Publication number: 20110059959
    Abstract: The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
    Type: Application
    Filed: November 18, 2010
    Publication date: March 10, 2011
    Applicant: CEPHALON, INC.
    Inventors: Sankar Chatterjee, James L. Diebold, Derek Dunn, Robert L. Hudkins, Reddeppareddy Dandu, Gregory J. Wells, Allison L. Zulli
  • Novel Fused Pyrrolocarbazoles
    Publication number: 20100152196
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Application
    Filed: February 18, 2010
    Publication date: June 17, 2010
    Applicant: CEPHALON, INC.
    Inventors: Nadine C. Becknell, James L. Diebold, Diane E. Gingrich, Robert L. Hudkins, Dandu R. Reddy, Ming Tao, Theodore L. Underiner, Allison L. Zulli
  • Fused pyrrolocarbazoles
    Patent number: 7671064
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: March 2, 2010
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, Allison L. Zulli, Dandu R. Reddy, Diane E. Gingrich, Ming Tao, Nadine C. Becknell, James L. Diebold, Theodore L. Underiner
  • FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS
    Publication number: 20090221555
    Abstract: The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
    Type: Application
    Filed: October 23, 2007
    Publication date: September 3, 2009
    Applicants: Cephalon, Inc., Pharmacopeia Drug Discovery, Inc.
    Inventors: Gulzar Ahmed, Adolph Bohnstedt, Henry Joseph Breslin, Jason Burke, Matthew A. Curry, James L. Diebold, Bruce Dorsey, Benjamin J. Dugan, Daming Feng, Diane E. Gingrich, Tao Guo, Koc-Kan Ho, Keith S. Learn, Joseph G. Lisko, Rong-qiang Liu, Eugen Mesaros, Karen Milkiewicz, Gregory R. Ott, Jonathan Parrish, Jay P. Theroff, Tho V. Thieu, Rabindranath Tripathy, Theodore L. Underiner, Jason C. Wagner, Linda Weinberg, Gregory J. Wells, Ming You, Craig A. Zificsak
  • Method of radio-sensitizing tumors using a radio-sensitizing agent
    Publication number: 20080146556
    Abstract: The present invention relates to a method of treating cancer using PARP inhibitors as radio-sensitization agents of tumors. Specifically the present invention relates to a method of radio-sensitization of tumors using a compound of Formula (I) or a pharmaceutically acceptable salt form thereof. The present invention also relates to a pharmaceutical compositions of PARP inhibitors for radiosensitizing tumors.
    Type: Application
    Filed: November 20, 2007
    Publication date: June 19, 2008
    Applicant: Cephalon, Inc.
    Inventors: James L. Diebold, Robert L. Hudkins, Sheila J. Miknyoczki, Bruce Ruggeri
  • Fused pyrrolocarbazoles
    Patent number: 7169802
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: January 30, 2007
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, Allison L. Zulli, Dandu R. Reddy, Diane E. Gingrich, Ming Tao, Nadine C. Becknell, James L. Diebold, Theodore L. Underiner
  • Multicatalytic protease inhibitors
    Patent number: 5990083
    Abstract: Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: November 23, 1999
    Assignee: Cephalon, Inc.
    Inventors: Mohamed Iqbal, James L. Diebold, Robert Siman, Sankar Chatterjee, James C. Kauer
  • Multicatalytic protease inhibitors
    Patent number: 5830870
    Abstract: Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: November 3, 1998
    Assignee: Cephalon, Inc.
    Inventors: Mohamed Iqbal, James L. Diebold, Robert Siman, Sankar Chatterjee, James C. Kauer
  • Fused pyrrolo?2,3-C! carbazole-6-ones
    Patent number: 5801190
    Abstract: Disclosed in this patent document are synthetic, biologically active molecules referred to as fused pyrrolo?2,3-c!carbazole-6-ones. These molecules are represented by the following general formulae: ##STR1## Methods for making and using the fused pyrrolo?2,3-c!carbazole-6-ones are also disclosed.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: September 1, 1998
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, James L. Diebold, Ernest Knight, Jr.
  • Fused pyrrolo[2,3-c]carbazole-6-ones
    Patent number: 5616724
    Abstract: Disclosed in this patent document are synthetic, biologically active molecules referred to as fused pyrrolo[2,3-c]carbazole-6-ones. These molecules are represented by the following general formulae: ##STR1## Methods for making and using the fused pyrrolo[2,3-c]carbazole-6-ones are also disclosed.
    Type: Grant
    Filed: February 21, 1996
    Date of Patent: April 1, 1997
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, James L. Diebold, Ernest Knight, Jr.
  • Multicatalytic protease inhibitors
    Patent number: 5614649
    Abstract: Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.
    Type: Grant
    Filed: November 3, 1995
    Date of Patent: March 25, 1997
    Assignee: Cephalon, Inc.
    Inventors: Mohamed Iqbal, James L. Diebold, Robert Siman, Sankar Chatterjee, James C. Kauer
  • Multicatalytic protease inhibitors
    Patent number: 5550262
    Abstract: Disclosed herein are inbibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: August 27, 1996
    Assignee: Cephalon, Inc.
    Inventors: Mohamed Iqbal, James L. Diebold, Robert Siman, Sankar Chatterjee, James C. Kauer