Abstract: Methods for administering oligonucleotides, nucleotide analogs, and non-nucleotide disruptor compounds to modulate the NK-1receptor biosynthetic pathway in humans and other mammals are provided. Oligonucleotides, and especially antisense oligonucleotides complementary to nucleic acids in the pathway that produces the NK-1 receptor, and those complementary to nucleic acids in pathways that regulate NK-1 receptor production and function, are useful, inter alia, to reduce pain, inflammation, and the undesirable effects of many diseases and conditions that involve NK-1 receptors. Non-nucleotide disrupter compounds and nucleotide analog compounds that act to modulate the NK-1receptor biosynthetic pathway to thereby regulate NK-1 receptor production and function, are similarly useful. The invention relates also to pharmaceutical preparations for humans and other mammals containing one or more oligonucleotides, nucleotide analogs, or non-nucleotide disrupter compounds.

Abstract: A coordinate measuring machine (10) having a three point support for a work supporting table (24) mounted over a base (12) constructed of a thermally dissimilar material. A first fixed support, (26A) and a laterally compliant second support (26B) are located at the front of the machine. The second front support (26B) is comprised of a pair of webs (28) oriented to be compliant in the lateral direction to allow relative thermal growth between the table (24) and base (12) while being rigid in the longitudinal direction to prevent rotation of the table (24) about the fixed front support (26A). Stacked crossed roller bearings (38A, 38B) provide a frictionless third point of support at the rear of the table (24).

Abstract: The present invention is a one-bit full adder circuit having a fast carry. The circuit may be implemented using integrated injection logic in which case the circuit comprises six NAND gates and two wired AND gates. Advantageously, there is only a single gate delay in the carry path.

Abstract: The disclosure shows a telephone range extender which is automatically adaptable to the length of the connected subscriber loop. A loop resistance detector within the range extender discriminates between loops within a plurality of ranges of lengths. For extremely short loops not requiring range extension, the range extender circuits are disconnected from the loop. For intermediate length loops, the gain of a bidirectional voice frequency amplifier is set at a low value to provide just sufficient gain for these loops. For longer loops, the gain of the amplifier is increased to provide sufficient amplification for the longer range. For extremely long loops, the range extender is disconnected since such loops must be served by remote amplification facilities. An automatic range extender of this type is shown connected behind the first stage of the central office switch in order to concentrate range extenders on a larger plurality of subscriber loops.

Abstract: A line current measuring arrangement employs two separate toroidal cores with line windings and control windings. The line windings cause equal amounts of the same polarity of magnetizing intensity H in the cores when a line current flows. The control windings are pulsed by control signals to cause equal changes of opposite polarity of control H in the two cores to drive the two cores to opposite polarities of saturation of magnetic induction B. The same control windings also provide a succession of voltage pulses where the amplitudes and polarities of the pulses are measures of differences in the changes of B in the two cores. A succession of voltage pulses is cumulatively and algebraically integrated to provide a changing output voltage which is a measure of the cumulative integration. The output voltage is effective through the agency of the same control windings to cause feedback H in both cores in opposition to any line H.

Abstract: A multi-axis load cell of the type adapted to generate signals corresponding to each of the various force and moment components exerted on the load cell is disclosed, comprised of a hub and a housing interconnected by three flexure arms, each flexure arm fixed at one end to one of the hub or housing and at the other end to a beam flexure element fixed to the other of the hub or housing. Each flexure beam is designed to be readily deflected in directions aligned with its respective flexure arm but offers substantially greater resistance to deflection in other directions, so that a centering bias force is provided without restricting the bending deflection of the flexure arms relied on to measure the force and moment components.Two sets of displacement transducers are provided, each set consisting of three transducers, with the first set arranged in pinwheel fashion about the load cell axis to measure the XY displacement components and torsional about the load cell axis.

Abstract: A reorientation device for use with a general purpose object manipulator is disclosed, comprised of an arrangement for rotating the object while in the grasp of the manipulator through predetermined detented angles, this reorientation thereby reducing the range of manipulation motions required to be executed by the manipulator device. The specific reorientation arrangement includes pneumatically operated rack and pinion devices adapted to rotate turnover plates through a 180.degree. angle, each of the turnover plates being adapted to carry a respective one of a set of manipulator fingers. By means of a pneumatically operated interposer pin, the rotation of each turnover plate can be selectively arrested at a predetermined angle of rotation short of the full degree of rotation produced by the rack and pinion devices.