Patents by Inventor James L. Manley

James L. Manley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitory RNAs to RNA binding proteins hnRNPA1, hnRNPA2 and PTB and uses thereof
    Patent number: 9206426
    Abstract: Provided herein are methods to reduce or slow down cell growth, for example in a cancer cell comprising contacting a cell with an effective amount of a combination of inhibitory RNA molecules targeting hnRNPA1, hnRNPA2 and PTB. Provided are methods to identify agents which reduce the levels of hnRNPA1, hnRNPA2 or PTB. Provided are methods to identify agents which increase ratio of PKM1/PKM2 proteins, or reduce PKM2 levels, or increase PKM1 levels.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: December 8, 2015
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: James L. Manley, Mo Chen, Charles David, Jian Zhang
  • INHIBITORY RNAS TO RNA BINDING PROTEINS HNRNPA1, HNRNPA2 AND PTB AND USES THEREOF
    Publication number: 20130203835
    Abstract: Provided herein are methods to reduce or slow down cell growth, for example in a cancer cell comprising contacting a cell with an effective amount of a combination of inhibitory RNA molecules targeting hnRNPA1, hnRNPA2 and PTB. Provided are methods to identify agents which reduce the levels of hnRNPA1, hnRNPA2 or PTB. Provided are methods to identify agents which increase ratio of PKM1/PKM2 proteins, or reduce PKM2 levels, or increase PKM1 levels.
    Type: Application
    Filed: March 7, 2011
    Publication date: August 8, 2013
    Inventors: James L. Manley, Mo Chen, Charles David, Jian Zhang
  • Peptide that kills growing but not stationary cells
    Patent number: 6696546
    Abstract: The present invention provides purified and synthetic peptides comprising the amino acid sequences shown in SEQ ID NO: 1 and SEQ ID NO: 3. The invention also provides pharmaceutical compositions comprising the peptides and methods of killing dividing cells and treating abnormalities and tumors in a subject using the peptides.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: February 24, 2004
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Gareth Lane Bond, James L. Manley, Carol Prives