Patents by Inventor James L. McGrath

James L. McGrath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11931739
    Abstract: Provided are methods, devices, and kits for the isolation and detection of one or more analytes of interest from a biological sample using microslit filter membranes. In various examples, the methods use capture particles and binding agents for specific recognition of one or more analytes of interest.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: March 19, 2024
    Assignees: SiMPore Inc., University of Rochester
    Inventors: James A. Roussie, James L. McGrath, Richard E. Waugh, Kilean S. Lucas, Joshua J. Miller
  • Publication number: 20210325386
    Abstract: The invention provides devices and methods for detecting viruses, bacteria, and other analytes of interest in a fluid sample. The fluid sample flows through a first microfluidic channel to a nanoporous or microporous membrane on which are disposed ligands, such as antibodies, specific for the analyte. If the analyte of interest is captured by the ligand, it clogs the pores of the membrane, preventing the fluid sample from passing through the membrane and diverting the fluid into a second channel. Detecting movement of the fluid sample in the second channel signals the presence of the analyte in the fluid sample, while failure of the fluid sample to move in the second channel signals absence of the analyte in the fluid sample.
    Type: Application
    Filed: February 15, 2021
    Publication date: October 21, 2021
    Applicant: University of Rochester
    Inventor: James L. McGrath
  • Publication number: 20210129146
    Abstract: Provided are methods, devices, and kits for the isolation and detection of one or more analytes of interest from a biological sample using microslit filter membranes. In various examples, the methods use capture particles and binding agents for specific recognition of one or more analytes of interest.
    Type: Application
    Filed: August 16, 2018
    Publication date: May 6, 2021
    Inventors: James A. Roussie, James L. McGrath, Richard E. Waugh, Kilean S. Lucas, Joshua J. Miller
  • Publication number: 20200333311
    Abstract: Provided are methods of preparing, detecting, and/or assaying an analyte of interest from a sample. The methods utilize functionalized silicon membranes, such as, for example, functionalized silicon nanomembranes. Samples that can be used in the methods may be biological samples, food samples, environmental samples, industrial samples, or a combination thereof. Also provided are kits to perform methods of the present disclosure.
    Type: Application
    Filed: January 7, 2019
    Publication date: October 22, 2020
    Inventors: Jared A. CARTER, James A. ROUSSIE, Gregory MADEJSKI, James L. McGRATH
  • Publication number: 20200191767
    Abstract: To reduce unwanted variation in the speed of DNA translocating solid-state nanopores, a nanoscale pre-confinement of translocating molecules is demonstrated using an ultra-thin nanoporous silicon nitride (NPN) membrane separated from a single sensing nanopore by a nanoscale cavity. Comprehensive experimental results demonstrate that the presence of this nanofilter results in a global minimum in the coefficient of variation of passage times in the sensing pore over a range of DNA sizes which depends on the height of the cavity. Such advanced nanopore devices minimize the standard deviation of the passage time distribution independently of its diameter and stability. These results also represents the first experimental verification that the inter- and intra-molecular passage time variation depends on the conformational entropy of such molecule prior to translocation, while providing a practical strategy for controlling transport across solid-state nanopores.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 18, 2020
    Inventors: Vincent TABARD-COSSA, Kyle BRIGGS, Gregory MADEJSKI, James L. MCGRATH
  • Patent number: 9437988
    Abstract: An electrical connector is provided with a first ground contact and a second ground contact. The first ground contact includes a first ground coupling portion and a pair of first ground contact portions extending substantially orthogonal from the first ground coupling portion. The pair of first ground contact portions includes a first upper ground contact portion stepped from a first lower ground contact portion. The second ground contact includes a second ground coupling portion and a pair of second ground contact portions extending substantially orthogonal from the second ground coupling portion. The pair of second ground contact portions includes a second upper ground contact portion stepped from a second lower ground contact portion. The second ground contact is positioned with the first ground contact such that their respective upper or lower ground contact portions are adjacent to each other.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: September 6, 2016
    Assignees: Tyco Electronics Corporation, Tyco Electronics Japan G.K.
    Inventors: James L. McGrath, Takeshi Nakashima, Izumi Hasegawa, Isao Igarashi
  • Patent number: 9397424
    Abstract: Connector assembly including a board connector configured to be mounted to a circuit board. The board connector includes a connector housing having a reception slot. The reception slot opens in a vertical direction that is parallel to an elevation axis. The elevation axis is perpendicular to the circuit board when the board connector is mounted thereto. The board connector also includes electrical contacts that are positioned along the reception slot. The electrical contacts are configured to engage corresponding contacts of a module card. The connector assembly also includes a coupling mechanism attached to the board connector. The coupling mechanism includes a support frame that extends away from the board connector along the elevation axis. The coupling mechanism also includes a latch body that is attached to the support frame and faces the reception slot to define a module-receiving space therebetween that is configured to receive the module card.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: July 19, 2016
    Assignee: Tyco Electronics Corporation
    Inventors: Stephen N. Figuerado, James L. McGrath
  • Publication number: 20160149323
    Abstract: Connector assembly including a board connector configured to be mounted to a circuit board. The board connector includes a connector housing having a reception slot. The reception slot opens in a vertical direction that is parallel to an elevation axis. The elevation axis is perpendicular to the circuit board when the board connector is mounted thereto. The board connector also includes electrical contacts that are positioned along the reception slot. The electrical contacts are configured to engage corresponding contacts of a module card. The connector assembly also includes a coupling mechanism attached to the board connector. The coupling mechanism includes a support frame that extends away from the board connector along the elevation axis. The coupling mechanism also includes a latch body that is attached to the support frame and faces the reception slot to define a module-receiving space therebetween that is configured to receive the module card.
    Type: Application
    Filed: December 12, 2014
    Publication date: May 26, 2016
    Inventors: Stephen N. Figuerado, James L. McGrath
  • Publication number: 20160111833
    Abstract: An electrical connector is provided with a first ground contact and a second ground contact. The first ground contact includes a first ground coupling portion and a pair of first ground contact portions extending substantially orthogonal from the first ground coupling portion. The pair of first ground contact portions includes a first upper ground contact portion stepped from a first lower ground contact portion. The second ground contact includes a second ground coupling portion and a pair of second ground contact portions extending substantially orthogonal from the second ground coupling portion. The pair of second ground contact portions includes a second upper ground contact portion stepped from a second lower ground contact portion. The second ground contact is positioned with the first ground contact such that their respective upper or lower ground contact portions are adjacent to each other.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 21, 2016
    Inventors: James L. McGrath, Takeshi Nakashima, Izumi Hasegawa, Isao Igarashi
  • Patent number: 8771018
    Abstract: A card edge connector includes a housing having a mating end and a mounting end with a card edge slot configured to receive a circuit card therein. Signal contacts are held by the housing and have mating portions configured to be electrically coupled to corresponding signal pads of the circuit card and tail portions configured to be electrically coupled to a corresponding circuit board. Ground contacts are held by the housing and have tail portions configured to be electrically coupled to the circuit board, bifurcated portions extending from corresponding tail portion, first mating portions extending from corresponding bifurcated portions, and second mating portions extending from corresponding bifurcated portions.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: July 8, 2014
    Assignee: Tyco Electronics Corporation
    Inventor: James L. McGrath
  • Publication number: 20130316585
    Abstract: A card edge connector includes a housing having a mating end and a mounting end with a card edge slot configured to receive a circuit card therein. Signal contacts are held by the housing and have mating portions configured to be electrically coupled to corresponding signal pads of the circuit card and tail portions configured to be electrically coupled to a corresponding circuit board. Ground contacts are held by the housing and have tail portions configured to be electrically coupled to the circuit board, bifurcated portions extending from corresponding tail portion, first mating portions extending from corresponding bifurcated portions, and second mating portions extending from corresponding bifurcated portions.
    Type: Application
    Filed: May 24, 2012
    Publication date: November 28, 2013
    Applicant: Tyco Electronics Corporation
    Inventor: James L McGrath
  • Patent number: 8518276
    Abstract: A process for forming a porous nanoscale membrane is described. The process involves applying a nanoscale film to one side of a substrate, where the nanoscale film includes a semiconductor material; masking an opposite side of the substrate; etching the substrate, beginning from the masked opposite side of the substrate and continuing until a passage is formed through the substrate, thereby exposing the film on both sides thereof to form a membrane; and then simultaneously forming a plurality of randomly spaced pores in the membrane. The resulting porous nanoscale membranes, characterized by substantially smooth surfaces, high pore densities, and high aspect ratio dimensions, can be used in filtration devices, microfluidic devices, fuel cell membranes, and as electron microscopy substrates.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: August 27, 2013
    Assignee: University of Rochester
    Inventors: Christopher C. Striemer, Philippe M. Fauchet, Thomas R. Gaborski, James L. McGrath
  • Patent number: 8501668
    Abstract: The invention provides a porous nanoscale membrane. In one embodiment, the membrane can be used as a filtration device to screen agents that disrupt or prevent molecular interactions. In one embodiment, the membrane allows for screening agents that disrupt or prevent molecular interactions using a small sample volume with efficient high-throughput screening applications.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: August 6, 2013
    Assignee: University of Rochester
    Inventors: James L. McGrath, Harold C. Smith
  • Publication number: 20130017716
    Abstract: The cable assembly may include a plug connector, a cable, and a connector. The plug connector may include a housing and a board assembly. The board assembly may include a printed circuit board. The edge of the printed circuit board may be enclosed with a material. The material may be an overmolded plastic or a coating of a material. In order to reduce the crosstalk in the areas where the cable shield is removed, a shielding assembly may be used. The shielding assembly may provide 360 degrees of shielding for the wire pair at the location where the cable shield is removed. The printed circuit board may have a trace layer, a core layer, and a ground plane layer. The ground plane layer may have a portion which is a solid layer and another portion which is a non-solid layer.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 17, 2013
    Applicant: Cinch Connectors, Inc.
    Inventors: Hecham K. Elkhatib, James L. McGrath, David W. Mendenhall, William J. MacKiliop, Alan A. Raclawski
  • Patent number: 8337243
    Abstract: The cable assembly may include a plug connector, a cable, and a connector. The plug connector may include a housing and a board assembly. The board assembly may include a printed circuit board. The edge of the printed circuit board may be enclosed with a material. The material may be an overmolded plastic or a coating of a material. In order to reduce the crosstalk in the areas where the cable shield is removed, a shielding assembly may be used. The shielding assembly may provide 360 degrees of shielding for the wire pair at the location where the cable shield is removed. The printed circuit board may have a trace layer, a core layer, and a ground plane layer. The ground plane layer may have a portion which is a solid layer and another portion which is a non-solid layer.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: December 25, 2012
    Assignee: Cinch Connectors, Inc.
    Inventors: Hecham K. Elkhatib, James L. McGrath, David W. Mendenhall, William J. MacKillop, Alan A. Raclawski
  • Patent number: 8298009
    Abstract: The cable assembly may include a plug connector, a cable, and a connector. The plug connector may include a housing and a board assembly. The board assembly may include a printed circuit board. The edge of the printed circuit board may be enclosed with a material. The material may be an overmolded plastic or a coating of a material. In order to reduce the crosstalk in the areas where the cable shield is removed, a shielding assembly may be used. The shielding assembly may provide 360 degrees of shielding for the wire pair at the location where the cable shield is removed. The printed circuit board may have a trace layer, a core layer, and a ground plane layer. The ground plane layer may have a portion which is a solid layer and another portion which is a non-solid layer.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: October 30, 2012
    Assignee: Cinch Connectors, Inc.
    Inventors: Hecham K. Elkhatib, James L. McGrath, David W. Mendenhall, William J. MacKillop, Alan A. Raclawski
  • Publication number: 20120267337
    Abstract: A process for forming a porous nanoscale membrane is described. The process involves applying a nanoscale film to one side of a substrate, where the nanoscale film includes a semiconductor material; masking an opposite side of the substrate; etching the substrate, beginning from the masked opposite side of the substrate and continuing until a passage is formed through the substrate, thereby exposing the film on both sides thereof to form a membrane; and then simultaneously forming a plurality of randomly spaced pores in the membrane. The resulting porous nanoscale membranes, characterized by substantially smooth surfaces, high pore densities, and high aspect ratio dimensions, can be used in filtration devices, microfluidic devices, fuel cell membranes, and as electron microscopy substrates.
    Type: Application
    Filed: April 20, 2012
    Publication date: October 25, 2012
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Christopher C. STRIEMER, Philippe M. FAUCHET, Thomas R. GABORSKI, James L. MCGRATH
  • Patent number: 8292647
    Abstract: A socket connector includes a dielectric housing extending longitudinally between a first end and a second end. The dielectric housing has a slot that extends longitudinally. The slot is configured to receive a circuit card therein. Contacts are held by the dielectric housing and exposed at the slot. The contacts are configured to be electrically connected to the circuit card. The contacts are configured to be terminated to a circuit board. A latch is provided at the first end and is configured to secure the circuit card in the dielectric housing. The latch includes a power conductor. The power conductor is configured to be electrically connected to the circuit card. The power conductor is configured to be terminated to the circuit board to supply power between the circuit board and the circuit card.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: October 23, 2012
    Assignees: Tyco Electronics Corporation, Tyco Electronics (Shanghai) Co., Ltd.
    Inventors: James L. McGrath, Richard Ma
  • Publication number: 20120171087
    Abstract: The present invention is drawn to methods for facilitating fluid flow through the nanopores of membranes, i.e., through sub-micron pores. The present invention is also directed to one or more apparatus for such fluid flow, and for nanoporous membranes modified to facilitate such fluid flow.
    Type: Application
    Filed: October 1, 2010
    Publication date: July 5, 2012
    Applicant: SIMPORE, INC.
    Inventors: Thomas R. Gaborski, James L. McGrath, Richard D. Richmond, Christopher C. Striemer
  • Patent number: 8182590
    Abstract: A process for forming a porous nanoscale membrane is described. The process involves applying a nanoscale film to one side of a substrate, where the nanoscale film includes a semiconductor material; masking an opposite side of the substrate; etching the substrate, beginning from the masked opposite side of the substrate and continuing until a passage is formed through the substrate, thereby exposing the film on both sides thereof to form a membrane; and then simultaneously forming a plurality of randomly spaced pores in the membrane. The resulting porous nanoscale membranes, characterized by substantially smooth surfaces, high pore densities, and high aspect ratio dimensions, can be used in filtration devices, microfluidic devices, fuel cell membranes, and as electron microscopy substrates.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: May 22, 2012
    Assignee: University of Rochester
    Inventors: Christopher C. Striemer, Philippe M. Fauchet, Thomas R. Gaborski, James L. McGrath