Abstract: A medical device known as an implantable therapeutic substance infusion device is configured for implanting in humans to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spastisity, cancer, and many other conditions. The therapeutic substance infusion device has a piston pump with an anti-cavitation valve to reduce gas formation, increase accuracy, improve efficiency and has many other improvements. The therapeutic substance infusion device has a housing, a therapeutic substance reservoir, a power source carried in the housing, electronics, a piston pump, an inlet valve, and anti-cavitation valve. The piston pump is configured for pumping therapeutic substance from the therapeutic substance reservoir through an infusion port at a programmed rate.

Abstract: A pharmaceutical composition, having utility as a diuretic or aldosterone antagonist, comprising spironolactone and an aqueous homogenizingly effective amount of a material selected from the group consisting of (i) sodium carboxymethylcellulose, and (ii) a mixture of methylcellulose and a dimethylpolysiloxane polymer.Also disclosed is a method of diuretic or hyperaldosteronism treatment by administration of such composition, e.g., by oral administration.

Abstract: An antibiotic composition comprising rifampin, a dimethyl polysiloxane polymer, and a cationic or non-ionic surfactant, wherein the rifampin, dimethyl polysiloxane polymer, and surfactant are present in relative amounts such that the composition is aqueously homogenizable with low foaming.Also disclosed is a method of antibiotic treatment wherein such composition is administered orally, either in a solid dosage form or in an aqueous medium.

Abstract: A novel alkali metal cation-charged, cation exchange resin is provided. The resin includes about 15-50 mEq % of calcium ion, and about 5-13 mEq % of magnesium ion. The calcium ion and magnesium ion loading prevent serious depletion of alkaline earth metal values from body fluids. Also provided is a method of treating a host having hypernatremia or hyperkalemia, using the resin. In one embodiment, the resin includes a supplementary amount of bioavailable calcium ion.

Abstract: In the salting of vegetables, such as cucumbers, control of fermentation using brine acidity as the monitor and continually and rapidly determining brine acidity with tris(hydroxymethyl)aminomethane as a standard.