Abstract: A genealogical research and record keeping system and method for identifying commonalities in haplotypes and other genetic characteristics of a biological sample of two or more individual members. Chromosomal fragments identical by descent identify family ties between siblings, parents and children and ancestors and progeny across many generations. It is particularly useful in corroborating and improving the accuracy of genealogical data and identifying previously unknown genetic relationships.

Abstract: A genealogical research and record keeping system and method for identifying commonalities in haplotypes and other genetic characteristics of two or more individual members of a biological sample. Chromosomal fragments identical by descent identify family ties between siblings, parents and children and ancestors and progeny across many generations. It is particularly useful in corroborating and improving the accuracy of genealogical data, and identifying previously unknown genetic relationships.

Abstract: A method, system and device for visually spatial caller identification includes a caller identification visual alerting device configured to capture current caller identification information from an incoming call. A stored caller identification list stores a plurality of entries of reference caller identification information and a corresponding respective plurality of entries of spatial visual indicator patterns. The reference caller identification information is matched with the current caller identification information. The caller identification visual alerting device further includes a spatial visual indicator configured to activate a plurality of illuminatable elements according to one of the plurality of spatial visual indicator patterns.

Abstract: A glucose sensor assembly useful in patient systems includes an oxygen sensor from which glucose levels in the vicinity of the peritoneal cavity may be inferred. The sensor assembly may be associated with electronics, such as any or all of a DC power supply, an LED source of blue light, a photoreceptor for red light, a CPU, and transceiver, by a direct percutaneous connection. Alternatively they may be associated transdermally with the sensor and some of the electronics being located subdurally. Insulin infusion means are contemplated to respond manually or mechanically to information from the sensors through the CPU. Mechanical response may be automatic. Infusion means may be located subdurally. It is contemplated that the present invention enable revitalization or replacement of fluorescing compounds and glucose oxidase within the sensor assembly.

Abstract: An implantable biosensor assembly and system includes an enzymatic sensor probe from which subcutaneous and interstitial glucose levels may be inferred. The assembly may be associated by direct percutaneous connection with electronics, such as for signal amplification, sensor polarization, and data download, manipulation, display, and storage. The biosensor comprises a miniature probe characterized by lateral flexibility and tensile strength and has large electrode surface area for increased sensitivity. Irritation of tissues surrounding the probe is minimized due to ease of flexibility and small cross section of the sensor. Foreign body reaction is diminished due to a microscopically rough porous probe surface.

Abstract: A glucose sensor assembly useful in patient systems includes an oxygen sensor from which glucose levels in the vicinity of the peritoneal cavity may be inferred. The sensor assembly may be associated with electronics, such as any or all of a DC power supply, an LED source of blue light, a photoreceptor for red light, a CPU, and transceiver, by a direct percutaneous connection. Alternatively they may be associated transdermally with the sensor and some of the electronics being located subdurally. Insulin infusion means are contemplated to respond manually or mechanically to information from the sensors through the CPU. Mechanical response may be automatic. Infusion means may be located subdurally. It is contemplated that the present invention enable revitalization or replacement of fluorescing compounds and glucose oxidase within the sensor assembly.

Abstract: A genealogical research and record keeping system and method for identifying commonalities in haplotypes and other genetic characteristics of two or more individual members of a biological sample. Chromosomal fragments identical by descent identify family ties between siblings, parents and children and ancestors and progeny across many generations. It is particularly useful in corroborating and improving the accuracy of genealogical data, and identifying previously unknown genetic relationships.

Abstract: A pump assembly for ambulatory peritoneal dialysis transfer procedures includes a portable power supply geared to drive a high-volume peristaltic pump. A cassette of the pump comprises an encasement; tubing including an inner portion positioned within the encasement, a patient-side portion for connection to an indwelling peritoneal dialysis catheter and an opposing portion connectable to a system for containment and communication of a peritoneal dialysis solution which may be one single-compartment bag assembly; a safety valve for selectively occluding and permitting the communication of the solution through the inner portion; and a filter preferably interposed along the patient-side portion which filters air and particles from peritoneal dialysate that is flowing toward a patient and which allows peritoneal dialysate to flow substantially freely and unfiltered away from the patient.

Abstract: A pump assembly for ambulatory peritoneal dialysis transfer procedures includes a portable power supply geared to drive a high-volume peristaltic pump. A cassette of the pump comprises an encasement; tubing including an inner portion positioned within the encasement, a patient-side portion for connection to an indwelling peritoneal dialysis catheter and an opposing portion connectable to a system for containment and communication of a peritoneal dialysis solution which may be one single-compartment bag assembly; a safety valve for selectively occluding and permitting the communication of the solution through the inner portion; and a filter preferably interposed along the patient-side portion which filters air and particles from peritoneal dialysate that is flowing toward a patient and which allows peritoneal dialysate to flow substantially freely and unfiltered away from the patient.

Abstract: A nail-permeable medication means is disclosed for delivering a medicament through nails, claws, hoofs, or other similar hardened tissue of dermal derivation. The nail-permeable medication means includes a proteolytic enzyme component which facilitates permeation of substances through the hardened nail or keratin tissue, and also includes a medicament component selected to treat a specific disease. The nail-permeable medication means is particularly useful for treating onychomycosis of the fingernail or toenail, and avoids the need for more drastic therapeutic modalities, such as removal of the nail.

Abstract: A nail-permeable medication means is disclosed for delivering a medicament through nails, claws, hoofs, or other similar hardened tissue of dermal derivation. The nail-permeable medication means includes a proteolytic enzyme component which facilitates permeation of substances through the hardened nail or keratin tissue, and also includes a medicament component selected to treat a specific disease. The nail-permeable medication means is particularly useful for treating onychomycosis of the fingernail or toenail, and avoids the need for more drastic therapeutic modalities, such as removal of the nail.

Abstract: A sealed ventilation circuit interface system, which enables simultaneous patient ventilation and safe tracheal suctioning, is structured to accommodate any of a wide variety of commercially available suction catheters. The interface system comprises a manifold assembly, and an adaptor. The manifold assembly may be attached to a patient for an extended period, while the adaptor is advantageously constructed as a single procedural use disposable device. The adaptor couples with the manifold assembly, and may be configured to effect the introduction of a catheter through a normally closed valve structure carried by the manifold assembly. The adaptor may alternatively be configured to interface the manifold with a bronchoscope or other appliance. A vacuum valve assembly biased in an open position is selectively actuated between open and closed positions and can be locked in a closed position. The vacuum valve remains at either position without ongoing manual pressure.

Abstract: A sealed ventilation circuit adapter that enables simultaneous patient ventilation and safe tracheal suctioning is embodied to accommodate any of a wide variety of commercially available suction catheters. The adapter comprises a manifold assembly, and a catheter carrier. The manifold assembly may be attached to a patient for an extended period, while the catheter carrier is advantageously constructed as a single procedural use disposable device. The carrier couples with the manifold assembly and functions to effect an introduction of a catheter through a normally closed valve structure carried by the manifold assembly.

Abstract: Novel apparatus and methods for a circumferential laser and methods for using a circumferential burning laser are disclosed. The circumferential burning laser comprises a conical surface at the distal end of a probe of the laser which is coated with a highly reflective material such as gold. The conical, reflective surface is designed so as to direct the laser light which is emitted through the interior metal lumen of the laser probe so that the laser light is redirected perpendicular to the longitudinal axis of the laser probe. This is in contradistinction to the typical laser probe wherein the laser light is directed longitudinally through the end of the laser probe. The laser light is provided by a carbon dioxide laser which is attached at the proximal end of the laser probe.The present invention also comprises methods for using a circumferential burning laser. The methods for using a circumferential burning laser involve placing the above-described laser probe in position relative to a target site.

Abstract: A ventilating and aspirating apparatus for delivering respiratory gases to the trachea and the congested lungs and breathing passageways of a patient includes a flexible catheter tube extendable into and withdrawable from the patient's trachea. The catheter is housed within a pliable sheath extending from a manifold that is attachable to an endotracheal tube. The sheath has a slit defined by backing members formed along elongate opposed edges. A releasable, air tight "ziplock" seal is effected at the slit by a bead on one backing member and a groove to sealingly receive the bead on the other backing member. A "ziplock" actuator is structured as a slider member which travels along the bead and groove, and includes converging ends to hold the bead in the groove and a conduit member extending centrally through the slider member to interconnect an end of the catheter tube inside the sheath through a vacuum valve carried by the slider member outside the sheath to a vacuum source.

Abstract: A surgical laser smoke evacuation system includes a sensor positioned at the surgical site to determine the need for evacuation. A vacuum pump draws smoke from the site through a system of conduits, including an in line filter. The filter tends to become clogged over time. A sensor determines changes in the pressure drop across the filter, and is connected to a control mechanism which adjusts the speed of the vacuum pump to maintain an approximately constant flow across the filter.

Abstract: The invention comprises a handpiece for use in a surgical procedure which involves directing a surgical agent to a target area of a person's body which procedure produces an unwanted smoke plume. The handpiece includes both a probe for directing a surgical agent, such as a CO.sub.2 laser beam, and a smoke eliminator for removing with suction the smoke created by the surgical procedure. The probe has no functional components for creating the laser beam, and is thus economical enough to be disposable after one use. The smoke eliminator includes a nozzle and/or an offset suction port so configured as to create a votrex flow in the smoke in the target area upstream in the fluid flow pathway of smoke through the hand piece from the distal tip of the hand piece.

Abstract: A laser surgical instrument is embodied as a handpiece supportable on the wrist and forearm of a surgeon. The handpiece is connected by an umbilical cord to a remote console. An internal shutter mechanism is actuated by steady finger pressure applied by the surgeon at a fixture grasped by the hand during use. An annular aiming beam is projected through an aperture in a physical distance gauge to focus concentric with the surgical laser beam.

Abstract: Computer operated projectors are positioned to project onto an uneven surface or relief map prepared to reflect a remote surface. If the remote surface is geographical, the surface is at a scale in which the horizontal scale is substantially larger than the vertical scale. A sound system provides surround sound. A second substrate or movie screen and projector are positioned to provide related video images.

Abstract: A cannula and method for bidirectional blood flow, the cannula being constructed so as to provide a bifurcated flow path, each branch of the flow path independently communicating through telescoping cannulae and a venipuncture needle initially projecting beyond the exterior cannula to facilitate venipuncture and thereafter being displaceable away from the venipuncture site to permit unobstructed simultaneous fluid flow in opposite directions through each of the bifurcated flow paths.