Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

Abstract: A metal or metal alloy foil substrate, preferably an unetched and uncoated metal or metal alloy foil substrate, such as but not limited to titanium, palladium, lead, nickel, tin, platinum, silver, gold, zirconium, molybdenum, tantalum, palladium-silver alloy, platinum-rhodium alloy, platinum-ruthenium alloy, and/or platinum-iridium alloy, is used as the cathode in an electrolytic capacitor, preferably an aluminum electrolytic capacitor having a multiple anode flat, stacked capacitor configuration. Despite a 120 Hz bridge capacitance measurement lower than with etched aluminum, the use of an unetched and uncoated metal or metal alloy foil cathode according to the present invention will inhibit gas production and not cause the capacitor to swell. Furthermore, an electrolytic capacitor built with a 30 micron unetched and uncoated foil cathode according to the present invention can deliver a stored to discharge energy ratio sufficient for use in pulse discharge applications, such as an in an ICD.

Abstract: A method for manufacturing an electrolytic capacitor with improved deformation qualities includes impregnating an electrolytic capacitor with a first electrolyte, aging the electrolytic capacitor after impregnating and reimpregnating the electrolytic capacitor with a second electrolyte. The water content of the second electrolyte is lower than the water content of the first electrolyte. The second electrolyte may also have a lower viscosity and a higher conductivity than the first electrolyte.

Abstract: A method of producing a highly etched electrode for a capacitor from a foil is disclosed. The method comprises first applying a composition to the foil to form a plurality of deposits on the foil surface. The method then includes heating the deposits to form micron-sized features and etching the foil. Preferably, the micron-sized features facilitate etching of the foil surface at the location of the micron-sized features. After etching, the foil is optionally further processed in a combination of optional steps such as widening, forming and finishing steps. The controlled application and heating of deposits on the foil surface allows for positional control of tunnel initiation during etching. Thus, the present invention relates to a method of controlling the etching of a foil, such that tunnel initiation density and the location of tunnel initiation is controlled.

Abstract: A process for producing high stability crystalline anodic aluminum oxide includes anodizing an anodic foil, hydrating the foil, and forming a barrier oxide layer on the foil. Anodizing the anodic foil produces nano-porous amorphous oxides which can then be converted to a crystalline precursor material by hydrating the foil. Next, an oxide layer formation step is utilized to form a barrier oxide layer on the surface of the anodized and hydrated foil. The resulting anodic oxides have very low levels of defects, voids and tensile stresses and have rise times as low as about 1 second to about 3 seconds after exposure of the formed samples to boiling water for 2 hours.

Abstract: Improved covers for electrolytic capacitors, offering both durability and low extractability of halides by high temperature electrolytes, can be produced from molding compositions comprising thermoset polymers having low halide extractability, preferably based on materials such as phenolic resins, and nonporous fillers, the compositions preferably being essentially free of porous fillers.

Abstract: Improved covers for electrolytic capacitors, offering both durability and low extractability of halides by high temperature electrolytes, can be produced from molding compositions including thermoset polymers having low halide extractability, preferably based on materials such as phenolic resins, and nonporous fillers, the compositions preferably being essentially free of porous fillers.

Abstract: An electrolytic solution is comprised of a borate, at least one dicarboxylic acid and at least one hydrotropic agent. The hydrotropic agent serves to maintain soluability at low temperatures, for example, in glycol type solvents. The invention also provides use of 1,10 dodecanedioic acid or dimer acid, thus improving the cost of the electrolyte is improved over use of branched chain dicarboxylic acids, while the use of the hydrotropic agent maintains solubility at acceptable temperatures.

Abstract: The invention provides a method of constructing an electrolytic capacitor with a heat sink, which includes attaching a surface area of the heat sink in intimate contact with a surface area of the capacitor. The invention also provides a method of constructing an electrolytic capacitor with a heat sink which includes the steps of (i) selecting a surface area of the electrolytic capacitor and a surface area of the heat sink for intimate contact, and (ii) attaching the surface area of the heat sink in intimate contact with and the surface area of the electrolytic capacitor. Moreover, the invention provides for an electrolytic capacitor constructed in accordance with the methods described above and also for a device including an electrolytic capacitor having a surface area in intimate contact with a surface area of a heat sink.

Abstract: The invention provides an improved electrolytic capacitor built having (i) an inactive core element; (ii) an active element wound around the inactive core element; and (iii) a package which houses both the active element and the inactive core element.

Abstract: Capacitance of anodized aluminum foil is increased by treating the foil after etching but before anodizing with an aqueous solution of a salt of valve metal, the oxide of which has a dielectric constant of at least about 20 and heating the foil to convert the salt to an oxide.

Abstract: An improved low voltage aluminum electrolytic capacitor foil produced by a method of controlled hydration in warm water without the use of passivators having increased capacitance for a given size and using less energy in its formation.

Abstract: The invention involves a method of preparing aluminum foil for use as an anode in electrolytic capacitors. The resultant electrolytic capacitor is improved by subjecting the etched aluminum foil to a heat treatment of 100.degree. to 600.degree. C. for about 10 seconds to 20 minutes prior to the treatment with nitric acid.

Abstract: In a cargo-transfer system wherein a truck-mounted boom is extendable into a cargo space to manipulate a cargo-lift mechanism, the improvement comprising a lowerable roller mechanism carried by the lift mechanism to slightly elevate the mechanism from the cargo space floor, thereby transferring the cargo weight to the floor, thus relieving the load that would otherwise have to be carried by the outboard end of the boom. The invention permits greater cargo weights and/or a greater extension of the boom, and/or a lighter and cheaper boom, and/or a lower cost power system.

Abstract: Method and apparatus for manufacturing portland cement characterized by a plurality of steps. First, there is introduced into the feed end of a rotary kiln at a first rate a first mixture containing calcareous material for the cement; and at a second rate a second mixture including at least one of argillaceous material and siliceous material for the cement. Either or both mixtures may be coarsely ground. Next, there is introduced into the combustion zone of the kiln at a third rate a third mixture and a fuel, the third rate of the third mixture being complementary with the second rate of the second mixture and the first rate of the first mixture so as to form a balanced cement clinker for the cement, the cement clinker being discharged from the discharge end of the kiln for further processing into the desired final form of the cement.