Patents by Inventor James L. Yeager

James L. Yeager has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250186448
    Abstract: Various methods and compositions for using udenafil, or a pharmaceutical acceptable salt thereof, for improving enhanced liver fibrosis (ELF) score for improving, maintaining/stabilizing, preventing and/or reducing the rate of decline of fibrotic impaired liver function, transforming a fibrotic liver to a less fibrotic liver, maintaining fibrotic liver condition, and/or reversing fibrotic liver condition and function in patients who have fibrotic livers, especially patients having single ventricle heart disease (SVHD) who have undergone Fontan surgery and have Fontan physiology.
    Type: Application
    Filed: January 18, 2025
    Publication date: June 12, 2025
    Inventor: James L. YEAGER
  • Publication number: 20250064817
    Abstract: The present invention relates generally to the field of using udenafil or a pharmaceutically acceptable salt thereof in patients who have undergone the Fontan operation.
    Type: Application
    Filed: July 8, 2024
    Publication date: February 27, 2025
    Inventors: James L. Yeager, David J. Goldberg, Stephen M. Paridon
  • Publication number: 20240285630
    Abstract: Various methods and compositions for treating single ventricle heart disease (SVHD) patients, including patients who have undergone Fontan surgery and who have Fontan circulation (Fontan patient), to improve exercise performance, especially to improve exercise performance at peak or max VO2 in a sub-super Fontan population, i.e., a subgroup of Fontan patients who have a baseline peak or max VO2 of less than (<) 80% predicted, and to improve exercise performance at ventilatory anaerobic threshold (“VAT”) in both the super Fontan population, i.e., Fontan patients who have a baseline peak or max VO2 of greater than (?) 80% predicted, and the sub-super Fontan population.
    Type: Application
    Filed: December 20, 2022
    Publication date: August 29, 2024
    Applicant: MEZZION PHARMA CO., LTD.
    Inventor: James L. YEAGER
  • Patent number: 12048701
    Abstract: The present invention relates generally to the field of using udenafil or a pharmaceutically acceptable salt thereof in patients who have undergone the Fontan operation.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: July 30, 2024
    Assignees: Mezzion Pharma Co., Ltd., Children's Hospital of Philadelphia
    Inventors: James L. Yeager, David J. Goldberg, Stephen M. Paridon
  • Publication number: 20230218622
    Abstract: Various methods and compositions for using udenafil, or a pharmaceutical acceptable salt thereof, for improving enhanced liver fibrosis (ELF) score for improving, maintaining/stabilizing, preventing and/or reducing the rate of decline of fibrotic impaired liver function, transforming a fibrotic liver to a less fibrotic liver, maintaining fibrotic liver condition, and/or reversing fibrotic liver condition and function in patients who have fibrotic livers, especially patients having single ventricle heart disease (SVHD) who have undergone Fontan surgery and have Fontan physiology.
    Type: Application
    Filed: August 12, 2022
    Publication date: July 13, 2023
    Inventors: David J. Goldberg, Mark W. Russell, Kurt R. Schumacher, James L. Yeager
  • Publication number: 20220047601
    Abstract: The present invention relates generally to the field of using udenafil or a pharmaceutically acceptable salt thereof in patients who have undergone the Fontan operation.
    Type: Application
    Filed: November 24, 2020
    Publication date: February 17, 2022
    Inventors: James L. Yeager, David J. Goldberg, Stephen M. Paridon
  • Patent number: 11229617
    Abstract: A topical composition includes a non-steroidal anti-inflammatory drug (NSAID) in an aqueous carrier system which contains a cationic galactomannan gum. The carrier system includes, in addition to water and the cationic galactomannan gum, a lactate ester of a C2 to C16 saturated aliphatic alcohol, a monoprotic arylalkanoic acid (pKa 3.8 to 5), a solubility enhancer, and a C2 to C8 saturated aliphatic alcohol.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: January 25, 2022
    Assignee: ACHELIOS THERAPEUTICS, INC.
    Inventors: Servet Buyuktimkin, Nadir Buyuktimkin, James L. Yeager
  • Publication number: 20200360325
    Abstract: A topical composition includes a non-steroidal anti-inflammatory drug (NSAID) in an aqueous carrier system which contains a cationic galactomannan gum. The carrier system includes, in addition to water and the cationic galactomannan gum, a lactate ester of a C2 to C16 saturated aliphatic alcohol, a monoprotic arylalkanoic acid (pKa 3.8 to 5), a solubility enhancer, and a C2 to C8 saturated aliphatic alcohol.
    Type: Application
    Filed: May 29, 2020
    Publication date: November 19, 2020
    Inventors: Servet Buyuktimkin, Nadir Buyuktimkin, James L. Yeager
  • Patent number: 10653698
    Abstract: The present invention relates generally to the field of using udenafil or a pharmaceutically acceptable salt thereof in patients who have undergone the Fontan operation.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: May 19, 2020
    Assignees: Mezzion Pharma Co., Ltd., The Children's Hospital of Philadelphia
    Inventors: James L. Yeager, David J. Goldberg, Stephen M. Paridon
  • Patent number: 10588873
    Abstract: Aqueous, topical compositions contain an allylamine or an azole as an antifungal agent together with a lactate ester, an organic acid (pKa 3.8-5), ethanol, water, and a cationic galactomannan gum.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: March 17, 2020
    Assignee: Exodos Life Sciences LP
    Inventors: Servet Buyuktimkin, Nadir Buyuktimkin, James L. Yeager
  • Publication number: 20190365682
    Abstract: A topical composition includes a non-steroidal anti-inflammatory drug (NSAID) in an aqueous carrier system which contains a cationic galactomannan gum. The carrier system includes, in addition to water and the cationic galactomannan gum, a lactate ester of a C2 to C16 saturated aliphatic alcohol, a monoprotic arylalkanoic acid (pKa 3.8 to 5), a solubility enhancer, and a C2 to C8 saturated aliphatic alcohol.
    Type: Application
    Filed: September 14, 2017
    Publication date: December 5, 2019
    Inventors: Servet Buyuktimkin, Nadir Buyuktimkin, James L. Yeager
  • Publication number: 20190151260
    Abstract: Aqueous, topical compositions contain an allylamine or an azole as an antifungal agent together with a lactate ester, an organic acid (pKa 3.8-5), ethanol, water, and a cationic galactomannan gum.
    Type: Application
    Filed: January 23, 2019
    Publication date: May 23, 2019
    Inventors: Servet Buyuktimkin, Nadir Buyuktimkin, James L. Yeager
  • Patent number: 10272054
    Abstract: Aqueous, topical antifungal compositions contain an allylamine or an azole as the antifungal agent together with a lactate ester, an organic acid (pKa 3.8-5), a C2 to C6 saturated aliphatic alcohol, and a cationic galactomannan gum.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: April 30, 2019
    Assignee: Exodos Life Sciences LP
    Inventors: Servet Buyuktimkin, Nadir Buyuktimkin, James L. Yeager
  • Publication number: 20190030037
    Abstract: The present invention relates generally to the field of using udenafil or a pharmaceutically acceptable salt thereof in patients who have undergone the Fontan operation.
    Type: Application
    Filed: September 28, 2018
    Publication date: January 31, 2019
    Inventors: James L. Yeager, David J. Goldberg, Stephen M. Paridon
  • Publication number: 20190030038
    Abstract: The present invention relates generally to the field of using udenafil or a pharmaceutically acceptable salt thereof in patients who have undergone the Fontan operation.
    Type: Application
    Filed: September 28, 2018
    Publication date: January 31, 2019
    Applicants: Mezzion Pharma Co., Ltd., The Children's Hospital of Philadelphia, The Children's Hospital of Philadelphia
    Inventors: James L. Yeager, David J. Goldberg, Stephen M. Paridon
  • Publication number: 20180369174
    Abstract: The present disclosure provides methods and compositions which treat, alleviate, prevent, diminish or otherwise ameliorate the symptoms associated with peripheral neuropathies (e.g., neuropathic pain) or sunburn in a subject. Specifically, the present invention relates to topically administering a therapeutically effective amount of a pharmaceutically safe therapeutic agent directly to the region exhibiting pain in a subject.
    Type: Application
    Filed: December 16, 2016
    Publication date: December 27, 2018
    Inventors: Crist J. FRANGAKIS, William WILKISON, Servet BUYUKTIMKIN, Nadir BUYUKTIMKIN, James L. YEAGER
  • Patent number: 10137128
    Abstract: The present invention relates generally to the field of using udenafil or a pharmaceutically acceptable salt thereof in patients who have undergone the Fontan operation.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: November 27, 2018
    Assignees: Mezzion Pharma Co., Ltd., The Children's Hospital of Philadelphia
    Inventors: James L. Yeager, David J. Goldberg, Stephen M. Paridon
  • Publication number: 20180271813
    Abstract: A sprayable analgesic composition is an aqueous ethanolic solution which contains a nonsteroidal anti-inflammatory drug (NSAID), lauryl lactate, lactic acid, glyceryl monolaurate, propylene glycol and optionally an alkoxylated alcohol.
    Type: Application
    Filed: November 4, 2015
    Publication date: September 27, 2018
    Inventors: Servet Buyuktimkin, Nadir Buyuktimkin, James L. Yeager
  • Publication number: 20180256516
    Abstract: Aqueous, topical antifungal compositions contain an allylamine or an azole as the antifungal agent together with a lactate ester, an organic acid (pKa 3.8-5), a C2 to C6 saturated aliphatic alcohol, and a cationic galactomannan gum.
    Type: Application
    Filed: October 7, 2016
    Publication date: September 13, 2018
    Inventors: Servet Buyuktimkin, Nadir Buyuktimkin, James L. Yeager
  • Publication number: 20180169103
    Abstract: The present invention relates generally to the field of using udenafil or a pharmaceutically acceptable salt thereof in patients who have undergone the Fontan operation.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 21, 2018
    Inventors: James L. Yeager, David J. Goldberg, Stephen M. Paridon