Patents by Inventor James Lah

James Lah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MASS SPECTROMETRY ANALYSIS OF MARKERS FOR ALZHEIMER'S DISEASE
    Publication number: 20260126454
    Abstract: Provided herein is a sensitive, quantitative, and scalable targeted proteomics assay of Alzheimer's Disease biomarkers representing neuronal, glial, vasculature and metabolic pathways. The biomarkers are protease-digested peptides selected from biological samples of individuals having normal A? and Tau levels (AT?) and from symptomatic and asymptomatic individuals having low A? and high Tau levels (AT+). The assay uses selective reaction monitoring-based mass spectrometry (SRM-MS) of peptides in the biological samples after digestion.
    Type: Application
    Filed: August 25, 2023
    Publication date: May 7, 2026
    Applicant: Emory University
    Inventors: Nicholas Seyfried, Duc Duong, Allan Levey, James Lah, Caroline Watson
  • Parallel Enzyme Digestion for Protein Biomarker Detection
    Publication number: 20210262006
    Abstract: This disclosure relates to isotopically labeled internal standards that can be digested by an enzyme capable of C-terminal cleavage of a first amino acid and/or an enzyme capable of N-terminal cleavage of a second amino acid useful to generate standards for the measurement of quantities of peptides of interest in a sample.
    Type: Application
    Filed: June 18, 2019
    Publication date: August 26, 2021
    Inventors: Nicholas Seyfried, Duc Duong, Allan Levey, Maotian Zhou, James Lah
  • RNA splicing alterations and U1 small nuclear ribonucleoproteins in neurodegenerative diseases
    Patent number: 9758809
    Abstract: This disclosure relates to methods of diagnosing neurodegenerative disease by analyzing proteins or protein expression profiles in a subject, or RNA or RNA expression profiles in a subject. In certain embodiments, the disclosure contemplates the diagnosis of preclinical or symptomatic stages of Alzheimer's disease, mild cognitive impairment, or chronic traumatic encephalopathy by identification of components of U1 small nuclear ribonucleoproteins or fragments thereof which are capable of forming cytoplasmic tangle-like structures.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: September 12, 2017
    Assignee: Emory University
    Inventors: Allan I Levey, Junmin Peng, James Lah, Bing Bai, Chadwick McKinley Hales, Ping-Chung Chen, Nicholas Thomas Seyfried