Abstract: Microfluidic devices for analyzing cellular components from biological samples which contain more than one cell type are provided. The microdevice separates cells by type, releases cellular components such as DNA (e.g. by cell lysis) and processes the cellular components (for example, by amplification) to generate products of interest for further analysis. Samples that can be analyzed using the microfluidic devices include forensic samples such as samples from sexual assault victims, and the products of interest include short tandem repeat (STR) amplicons for DNA profiling.

Abstract: A collection device for a biological sample to capture target compounds such as viruses or other pathogens or particles for testing from within the sample and move the captured target compound to a separate chamber for subsequent processing. The collection device can include an openable substance blister including capture particles located in a cup interior. Capture particles can attract and bind the target compounds from the sample. An extraction tube extracts any nucleic acid from the target compound for storage or subsequent amplification and testing to confirm presence of known microorganisms. The extraction tube can comprise a heat-deformable material and can be connected to a microfluidic cartridge for further processing of nucleic acid including, amplification and detection. The microfluidic cartridge includes valves and a plurality of chambers for amplification.

Abstract: A collection device for a biological sample to capture target compounds such as viruses or other pathogens or particles for testing from within the sample and move the captured target compound to a separate chamber for subsequent processing. The collection device can include an openable substance blister including capture particles located in a cup interior. Capture particles can attract and bind the target compounds from the sample. An extraction tube extracts any nucleic acid from the target compound for storage or subsequent amplification and testing to confirm presence of known microorganisms. The extraction tube can comprise a heat-deformable material and can be connected to a microfluidic cartridge for further processing of nucleic acid including, amplification and detection. The microfluidic cartridge includes valves and a plurality of chambers for amplification.

Abstract: A cartridge interface module (CIM), configured to engage with a removable microfluidic cartridge in a nucleic acid analyzer system can include a fluidics component, which is configured to initiate and support a liquid extraction of nucleic acids from a biological sample contained in the removable microfluidic cartridge. The CIM also includes a polymerase chain reaction (PCR) assembly component which can be configured to initiate and support amplification of the extracted nucleic acids. The CIM may also include a high voltage electrodes component that is configured to initiate and support separation of the amplified nucleic acids into nucleic acid fragments in a separation channel of the removable microfluidic cartridge. The CIM also includes a detection optics component that can be configured to collect, detect, and direct label nucleic acid fragments. The CIM is configured to integrate with a microfluidic chip architecture of an inserted removable microfluidic cartridge.

Abstract: A microfluidic cartridge can include at least one nucleic acid analysis portion. Each nucleic acid analysis portion can include a fluidic network being configured for micro-liter volumes or less, a sample input at the beginning of the fluidic network, a plurality of vent ports and fluidic channels in the fluidic network configured to effectuate hydrodynamic movement within the fluidic network, an extraction mixture reservoir in the fluidic network, a mixing chamber in the fluidic network, an amplification chamber in the fluidic network, and a separation channel in the fluidic network. A nucleic acid analyzer can be capable of performing nucleic acid analysis using the microfluidic cartridge. A nucleic acid analysis method can be performed using the microfluidic cartridge.

Abstract: A wheel and bracket device that is removably attachable to a ladder. The present invention allows users to more conveniently transport a ladder, ladder tree stand, or other such device, along with objects that may be supported thereon. The present invention is a bracket that is adapted to enclose a rail and a rung of a ladder and be securely affixed to the ladder via a locking mechanism, such as a locking pin. A wheel is rotatably attached to the bracket, thereby allowing users to push or pull the ladder across terrain, rather than being forced to carry the ladder.

Abstract: An integrated circuit (IC) chip containing a Delta-Sigma (??) filter module for a ?? analog-to-digital converter and a method of providing analog to digital conversion are disclosed. The IC chip includes a ?? filter that is connected to receive a digital data stream created by a ?? modulator, provide a multibit data value when a counter reaches a selected number of received bits, and reset the counter responsive to receiving a synchronization pulse. The IC chip also includes a FIFO buffer connected to store the multibit data value only when a synchronization flag is on and to send an interrupt towards a processing unit only after storing a selected number of multibit data values. The IC chip further includes a synchronization module connected to turn on the synchronization flag responsive to receiving the synchronization pulse and to turn off the synchronization flag responsive to the sending of the interrupt.

Abstract: An integrated circuit (IC) chip containing a Delta-Sigma (??) filter module for a ?? analog-to-digital converter and a method of providing analog to digital conversion are disclosed. The IC chip includes a ?? filter that is connected to receive a digital data stream created by a ?? modulator, provide a multibit data value when a counter reaches a selected number of received bits, and reset the counter responsive to receiving a synchronization pulse. The IC chip also includes a FIFO buffer connected to store the multibit data value only when a synchronization flag is on and to send an interrupt towards a processing unit only after storing a selected number of multibit data values. The IC chip further includes a synchronization module connected to turn on the synchronization flag responsive to receiving the synchronization pulse and to turn off the synchronization flag responsive to the sending of the interrupt.

Abstract: A microfluidic chip includes one or more reaction chambers to hold fluids for chemical or biochemical reactions, such as PCR. A non-contact heat source heats the reaction chamber and the fluid, such that the heat source does not contact the reaction chamber or the fluid. The heat source can heat the reaction chamber and the fluid separately, where the reaction chamber and the fluid separately absorb heat radiation from the heat source. A temperature sensor acquires a temperature of the reaction chamber and/or the fluid. Control circuitry controls the heat source according to a cycling profile for the reaction in the fluid to cycle the heat source between heating and not heating the reaction chamber and the fluid based on the temperature acquired by the temperature sensor. Cooling can be provided passively or actively.

Abstract: A microfluidic cartridge can include at least one nucleic acid analysis portion. Each nucleic acid analysis portion can include a fluidic network being configured for micro-liter volumes or less, a sample input at the beginning of the fluidic network, a plurality of vent ports and fluidic channels in the fluidic network configured to effectuate hydrodynamic movement within the fluidic network, an extraction mixture reservoir in the fluidic network, a mixing chamber in the fluidic network, an amplification chamber in the fluidic network, and a separation channel in the fluidic network. A nucleic acid analyzer can be capable of performing nucleic acid analysis using the microfluidic cartridge. A nucleic acid analysis method can be performed using the microfluidic cartridge.

Abstract: A microfluidic cartridge can include at least one nucleic acid analysis portion. Each nucleic acid analysis portion can include a fluidic network being configured for micro-liter volumes or less, a sample input at the beginning of the fluidic network, a plurality of vent ports and fluidic channels in the fluidic network configured to effectuate hydrodynamic movement within the fluidic network, an extraction mixture reservoir in the fluidic network, a mixing chamber in the fluidic network, an amplification chamber in the fluidic network, and a separation channel in the fluidic network. A nucleic acid analyzer can be capable of performing nucleic acid analysis using the microfluidic cartridge. A nucleic acid analysis method can be performed using the microfluidic cartridge.

Abstract: A method and circuit in which the drive strength of a FinFET transistor can be selectively modified, and in particular can be selectively reduced, by omitting the LDD extension formation in the source and/or in the drain of the FinFET. One application of this approach is to enable differentiation of the drive strengths of transistors in an integrated circuit by applying the technique to some, but not all, of the transistors in the integrated circuit. In particular in a SRAM cell formed from FinFET transistors the application of the technique to the pass-gate transistors, which leads to a reduction of the drive strength of the pass-gate transistors relative to the drive strength of the pull-up and pull-down transistors, results in improved SRAM cell performance.

Abstract: A wheel and bracket device that is removably attachable to a ladder. The present invention allows users to more conveniently transport a ladder, ladder tree stand, or other such device, along with objects that may be supported thereon. The present invention is a bracket that is adapted to enclose a rail and a rung of a ladder and be securely affixed to the ladder via a locking mechanism, such as a locking pin. A wheel is rotatably attached to the bracket, thereby allowing users to push or pull the ladder across terrain, rather than being forced to carry the ladder.

Abstract: A microfluidic chip includes one or more reaction chambers to hold fluids for chemical or biochemical reactions, such as PCR. A non-contact heat source heats the reaction chamber and the fluid, such that the heat source does not contact the reaction chamber or the fluid. The heat source can heat the reaction chamber and the fluid separately, where the reaction chamber and the fluid separately absorb heat radiation from the heat source. A temperature sensor acquires a temperature of the reaction chamber and/or the fluid. Control circuitry controls the heat source according to a cycling profile for the reaction in the fluid to cycle the heat source between heating and not heating the reaction chamber and the fluid based on the temperature acquired by the temperature sensor. Cooling can be provided passively or actively.

Abstract: A device and method of fabricating the same are disclosed. In an example, a device includes a first fin Field Effect Transistors (finFET) formed on a substrate. The first finFET including a fin formed on the substrate. The device further includes a second finFET formed on the substrate. The first finFET and the second finFET share the fin and wherein the first finFET is without any low density doped (LDD) extension region in the substrate and wherein the second FinFET is associated with a first LDD extension region formed in the substrate such that a drive strength of the second finFET is greater relative to a drive strength of the first finFET.

Abstract: A method and circuit in which the drive strength of a FinFET transistor can be selectively modified, and in particular can be selectively reduced, by omitting the LDD extension formation in the source and/or in the drain of the FinFET. One application of this approach is to enable differentiation of the drive strengths of transistors in an integrated circuit by applying the technique to some, but not all, of the transistors in the integrated circuit. In particular in a SRAM cell formed from FinFET transistors the application of the technique to the pass-gate transistors, which leads to a reduction of the drive strength of the pass-gate transistors relative to the drive strength of the pull-up and pull-down transistors, results in improved SRAM cell performance.

Abstract: A cartridge interface module (CIM), configured to engage with a removable microfluidic cartridge in a nucleic acid analyzer system can include a fluidics component, which is configured to initiate and support a liquid extraction of nucleic acids from a biological sample contained in the removable microfluidic cartridge. The CIM also includes a polymerase chain reaction (PCR) assembly component which can be configured to initiate and support amplification of the extracted nucleic acids. The CIM may also include a high voltage electrodes component that is configured to initiate and support separation of the amplified nucleic acids into nucleic acid fragments in a separation channel of the removable microfluidic cartridge. The CIM also includes a detection optics component that can be configured to collect, detect, and direct label nucleic acid fragments. The CIM is configured to integrate with a microfluidic chip architecture of an inserted removable microfluidic cartridge.

Abstract: An onboard system for a rotary wing aircraft detects a limit cycle oscillation in the tail mast and provides a timely indication of the limit cycle oscillation to an aircrew before serious damage to the airframe is likely to occur.

Abstract: An onboard system for a rotary wing aircraft detects a limit cycle oscillation in the tail mast and provides a timely indication of the limit cycle oscillation to an aircrew before serious damage to the airframe is likely to occur.

Abstract: This application relates to cast enclosures for battery replacement application, such as enclosures configured to house power units comprising a fuel cell and an energy storage device. The enclosures function as protective enclosures and counterweights, provide mounting points and conduits for gases, fluids, plumbing and wiring, and serve as thermal energy storage/transfer devices. The enclosures are formed in a mold or die and comprise wall portions defining a plurality of internal subcompartments for receiving the various system components. In one embodiment of the invention channels may be formed in the wall portions of the enclosures for circulating a heat transfer fluid therethrough.