Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Abstract: The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Abstract: This invention relates to a protective mouthguard for use by athletes that incorporates a color customizable feature, allowing users to customize the visible color of the mouthguard. The invented protective mouthguard has a u-shaped base that will fit inside of a user's mouth. The front surface of the mouthguard can be visible when the mouthguard is worn by the user inside of his mouth. A colorable strip is placed inside a cavity in the front wall of the mouthguard and is visible through holes that are placed in the front wall.

Abstract: This invention relates to a protective mouthguard for use by athletes that incorporates a color customizable feature, allowing users to customize the visible color of the mouthguard. The invented protective mouthguard has a u-shaped base that will fit inside of a user's mouth. The front surface of the mouthguard can be visible when the mouthguard is worn by the user inside of his mouth. A colorable strip is placed inside a cavity in the front wall of the mouthguard and is visible through holes that are placed in the front wall.

Abstract: A heart protector is described that comprises of an angular body. The angular body will have at least two contact points wherein the angular body is capable of being attached to a garment at said contact points such that the angular body is positioned in front of the heart of a user and said contact points are positioned at locations around the pectoral muscles of the user when said garment is worn by the user.

Abstract: This invention relates to a protective mouthguard for use by athletes that incorporates a color customizable feature, allowing users to customize the visible color of the mouthguard. The invented protective mouthguard has a u-shaped base that will fit inside of a user's mouth. The front surface of the mouthguard can be visible when the mouthguard is worn by the user inside of his mouth. A colorable strip is placed inside a cavity in the front wall of the mouthguard and is visible through holes that are placed in the front wall.

Abstract: A heart protector is described that comprises of an angular body. The angular body will have at least two contact points wherein the angular body is capable of being attached to a garment at said contact points such that the angular body is positioned in front of the heart of a user and said contact points are positioned at locations around the pectoral muscles of the user when said garment is worn by the user.

Abstract: A protective pad includes a pre-tensioned resilient padded membrane resiliently suspended to a semi-rigid shell. A cavity is defined between the pre-tensioned padded membrane and the shell. In use, the pad is attached to the limb or joint to be protected with the tensioned membrane engaging the limb or joint to be protected. The pre-tensioned membrane and air cushion in the cavity absorb the energy of an impact transferred by the shell during a sporting event or other activity.

Abstract: Manganese-free rare earth-transition metal AB5-type hydrogen-absorbing alloys having favorable high rate discharge characteristics, suitable for use in rechargeable batteries for electrical vehicles or hybrid electrical vehicles, include compositions of the general formula: R(CouAlvMwNi1−u−v−w)z, where R is at least one element selected from rare earth elements and yttrium (Y), M is at least one refractory metal selected from Groups IVB, VB, and VIB of the periodic table, the value of u is from 0 to about 0.25, v is from 0 to about 0.10, w is from 0 to about 0.05, and z, the ratio of R(CouAlvMwNi1−u−v−w)/R, is from about 4.70 to about 5.50. The unit cell volume is from about 87 to about 88.5 A3 at 25° C., the plateau pressure is from about 3 to about 10 apsi at 25° C., and the composition is essentially free of manganese.