Abstract: Disclosed herein are compounds useful for treating obstructive lung diseases. The compounds are TAS2Rs agonists and may further be used to treat disorders and conditions implicated by TAS2R. In some instances the disclosed compounds can be used to treat asthma.

Abstract: Disclosed herein are compounds that can prevent and treat C. difficile by inhibiting sporulation. Also disclosed herein are compositions and formulations comprising the compound disclosed herein. Methods of preventing and treating C. difficile comprising administering the compounds described herein are also disclosed.

Abstract: Disclosed herein are compounds that can prevent and treat C. difficile by inhibiting sporulation. Also disclosed herein are compositions and formulations comprising the compound disclosed herein. Methods of preventing and treating C. difficile comprising administering the compounds described herein are also disclosed.

Abstract: The present disclosure is directed to methods for the treatment of inflammation or pain, particularly methods using compositions containing a compound of formula (I).

Abstract: Disclosed herein are compounds useful for treating obstructive lung diseases. The compounds are TAS2Rs agonists and may further be used to treat disorders and conditions implicated by TAS2R. In some instances the disclosed compounds can be used to treat asthma.

Abstract: The present disclosure is directed to methods for the treatment of inflammation or pain, particularly methods using compositions containing a compound of formula (I).

Abstract: A patient interface includes a cushion having a body with a front portion and a rear portion. The front portion has a lower opening structured to receive a flow of a treatment gas and a coupling mechanism. The rear portion is structured to engage a user's face and provide a generally continuous seal therewith. The patient interface further includes a frame having a torus shaped portion defining an opening. The opening has at least a portion of the coupling mechanism disposed therein.

Abstract: A request for retrieving a cached data object from a data object cache used to cached data objects retrieved from one or more primary data sources is received from a data object requester. Responsive to determining that the cached data object in the data object cache is expired, it is determined whether the cached data object in the data object cache is still within an extended time period. If the cached data object in the data object cache is still within an extended time period, it is determined whether the cached data object is free of a cache invalidity state change caused by a data change operation. If the cached data object is free of a cache invalidity state change, the cached data object is returned to the data object requester.

Abstract: A request for retrieving a cached data object from a data object cache used to cached data objects retrieved from one or more primary data sources is received from a data object requester. Responsive to determining that the cached data object in the data object cache is expired, it is determined whether the cached data object in the data object cache is still within an extended time period. If the cached data object in the data object cache is still within an extended time period, it is determined whether the cached data object is free of a cache invalidity state change caused by a data change operation. If the cached data object is free of a cache invalidity state change, the cached data object is returned to the data object requester.

Abstract: A request for retrieving a cached data object from a data object cache used to cached data objects retrieved from one or more primary data sources is received from a data object requester. Responsive to determining that the cached data object in the data object cache is expired, it is determined whether the cached data object in the data object cache is still within an extended time period. If the cached data object in the data object cache is still within an extended time period, it is determined whether the cached data object is free of a cache invalidity state change caused by a data change operation. If the cached data object is free of a cache invalidity state change, the cached data object is returned to the data object requester.

Abstract: A patient interface includes a cushion having a body with a front portion and a rear portion. The front portion has a lower opening structured to receive a flow of a treatment gas and a coupling mechanism. The rear portion is structured to engage a user's face and provide a generally continuous seal therewith. The patient interface further includes a frame having a torus shaped portion defining an opening. The opening has at least a portion of the coupling mechanism disposed therein.

Abstract: An illumination source is disclosed that features, in one embodiment, an at least generally conical body extending outward along an axis of illumination, a socket supported with respect to the body having a pair of connector surfaces for receiving power and having an axis of insertion at least generally parallel to the axis of illumination, and one or more LED illumination elements supported with respect to the body such that at least a portion of their illumination axes are at least generally parallel to the axis of illumination of the source. A power supply has electrical inputs operatively connected to the socket and electrical outputs operatively connected to the LED illumination elements, and a front face is positioned opposite the socket along the illumination axis.

Abstract: An illumination source is disclosed that features, in one embodiment, an at least generally conical body extending outward along an axis of illumination, a socket supported with respect to the body having a pair of connector surfaces for receiving power and having an axis of insertion at least generally parallel to the axis of illumination, and one or more LED illumination elements supported with respect to the body such that at least a portion of their illumination axes are at least generally parallel to the axis of illumination of the source. A power supply has electrical inputs operatively connected to the socket and electrical outputs operatively connected to the LED illumination elements, and a front face is positioned opposite the socket along the illumination axis.

Abstract: In one general aspect, an LED-based illumination source is disclosed that includes a screw-in household base with an outer thread centered about an insertion axis. A directional-type illumination housing is mechanically connected to the base and has a round light delivery end centered around the insertion axis and has a diameter that is larger than the base. One or more LED illumination elements occupy a portion of the round light delivery end of the directional-type illumination housing and each has an optical axis at least generally parallel with the insertion axis and face away from the base. One or more at least generally coplanar lenses have at least generally parallel optical axes each being aligned with one of the elements and being positioned opposite from the base with respect to the elements.