Abstract: A bead construct includes a bead, a fluorophore molecule, first and second linker molecules and a ligand molecule. The fluorophore molecule comprises at least two subunits connected to each other by at least one internal linker that provides conformational freedom to the at least two subunits. An optical signal emitted by the fluorophore molecule changes when reducing the conformational freedom of the at least two subunits to each other. The first linker molecule is connected to the bead and to one of the subunits of the flurophore molecule. The second linker molecule is connected to another one of the subunits of the fluorophore molecule. The ligand molecule is connected to the second linker molecule.

Abstract: This invention includes a fluorophore-tagged antimalarial represented by the following structural formula (1) or a salt thereof. This invention relates to the synthesis of fluorophore-tagged antimalarials and describes the synthesis of a fluorophore-tagged antimalarial. These fluorophore-tagged antimalarials can be used to image live cells to determine the location of the antimalarial in the cell, identify drug resistance and growth related pathways in Plasmodium isolates, identify new drug targets and chemo-sensitizers to reverse drug resistance.

Abstract: A system for and method of investing a lump sum amount in order to return N periodic installments at a specified confidence level. A set of candidate investment instruments is selected from a universe of investment instruments. Data regarding the returns of the candidate investment vehicles during preceding periods is collected. Based on the data, minimum expected returns at the confidence level (MER) from each investment vehicle at the return date of each installment is compiled. Investment vehicles are selected for each of the N periods, with the selection criteria maximizing the MER for each of the respective periods. A normalization factor is developed that is based on the MERs of the selected investment vehicles, for the associated respective periods.

Abstract: A method of generating a SQL statement for retrieving a data set from a database via a user interface and a database server and then processing the data set recursively. The method comprises the following steps: a) inputting a nested n-pass expression to the user interface in a form that the database server cannot execute; and b) converting the nested n-pass expression into a SQL statement that the database server can execute, the SQL statement having a level of recursion for each level of nesting of the n-pass expression, each level of recursion operating in use on the results of at least one of the preceding levels.

Abstract: A memory cache interface (12) serially accesses each way in an M-way set asociative memory cache (11) when it performs a read operation. The memory cache returns a data quantum and a tag corresponding to each presented input. The memory cache interface presents a portion of a main memory address and a new value of a way signal to the memory cache until it finds a match between the output tag and the remainder of the main memory address. The memory cache interface allows set-associative caches to be constructed from simple memory blocks for use with devices in which the memory cache interface may be incorporated. The memory cache interface may be incorporated into such devices as data processors and microcontrollers.