Abstract: Systems and apparatuses include a cab floor defining a center plane, a seat slide actuator coupled to the cab floor and selectively moveable in a direction transverse to the center plane relative to the cab floor, and a seat supported by the seat slide actuator and moveable therewith.

Abstract: This disclosure relates generally to surgical retractors and surgical retractor systems configured to provide access to a surgical site, such as a portion of a patient's spine. Also disclosed are retractor blades or blade assemblies connectable to surgical retractors. A self-adjusting retractor blade includes a sheath extending from a proximal end to a distal end, with the sheath having an engagement portion at the proximal end configured for releasable engagement with a surgical retractor system, a channel extending to the distal end, and a blade tip at least partially contained within the channel, the blade tip configured to slide within the channel. The blade tip may be biased in a first position relative to the sheath. Methods of assembling and using the surgical retractors and surgical systems are also disclosed.

Abstract: The present invention relates to a non-invasive cardiac monitoring device that records cardiac data to infer physiological characteristics of a human, such as cardiac arrhythmias or other vital signs. Some examples of the invention allow for long-term monitoring of physiological signals. Further examples allow for processing of ECG and PPG data to calculate pulse arrival time. Some examples include a wearable cardiac monitor device on a chest that includes both the ECG and PPG sensor for long-term adhesion to a mammal for prolonged detection of cardiovascular signals.

Abstract: This application is directed to using a single instruction to initiate a sequence of computational operations related to a neural network activation function. An electronic device receives a single instruction to apply a linear activation operation to a set of first elements stored in one or more input vector registers. In response to the single instruction, the linear activation operation is implemented on the set of first elements to generate a set of output elements. For each first element, the electronic device detects a sign value of the respective first element, selects a respective scalar from one or more scalars based on the sign value, and applies the linear activation operation on the respective first element based on the selected respective scalar and a bias value to generate a respective element of the set of output elements. The electronic device quantizes the set of output elements.

Abstract: Certain aspects of the present disclosure provide techniques and apparatus for quantized machine learning. A quantized input matrix is accessed at a layer of a neural network, and a first interim value is generated in an accumulator by performing matrix multiplication, using the accumulator, of the quantized input matrix and a quantized weight matrix associated with the layer of the neural network. The first interim value is normalized based at least in part on one or more leading sign bits of the first interim value, and the normalized first interim value is dequantized. A second interim value is generated by applying a rounded right-shift operation to the dequantized normalized first interim value, and activation data is generated by applying an activation function to the second interim value.

Abstract: A storage device includes a non-volatile memory (NVM) device including an adjacent word line, a selected word line, and a storage controller. The storage controller transmits a command instructing a data recovery read operation for the selected word line to the NVM device. The NVM device applies at least one group determination read voltage to the adjacent word line to classify the adjacent memory cells into an aggressor cell group. In response to receiving the command, the NVM device generates read data for the selected word line based on a read voltage set and transmits the read data to the storage controller. If the first adjacent memory cells belong to a first aggressor cell group, the first sub-read voltage set is determined based on threshold voltage distributions associated with states of the selected memory cells and on a first coupling pattern by the first aggressor cell group.

Abstract: Topical compositions and methods for using topical compositions comprising tapinarof to treat mild to moderate atopic dermatitis or plaque psoriasis are described herein. Also described are clinical endpoints for treatment of subjects diagnosed with mild to moderate atopic dermatitis, wherein about 5% to about 35% of body surface area was affected, and Investigator Global Assessment (IGA) score was greater than or equal to 3. Also described are clinical endpoints for treatment of subjects diagnosed with chronic mild to moderate plaque psoriasis for greater than or equal to 6 months, wherein about 3% to about 20% of body surface area was affected, and Physician Global Assessment (PGA) score was greater than or equal to 2.

Abstract: A document response production method, the method including: receiving, as input, a document with requests for information, wherein each request for information is a text string; displaying a user interface on the display, the user interface simultaneously displaying a document viewer area, a virtual assistant area, and a text editor area; displaying the received document in the document viewer area; receiving, as input, a selected request for information from among the requests for information; displaying, in the virtual assistant area, one or more automatically selected recommended responses to the selected request for information, and displaying, in the virtual assistant area, one or more other selectable potential responses; based on the selected request for information, automatically generating or suggesting a text string response to the selected request for information; and displaying the text string response in the text editor area.

Abstract: The invention provides methods of identifying a subject having cancer, such as lung cancer, by analyzing expression levels of one or more NRF2 splice variants or NRF2 target genes. The invention also provides methods of treating cancer in a subject with a NRF2 pathway antagonist, wherein the subject expresses one or more NRF2 splice variants or overexpresses one or more NRF2 target genes.

Abstract: A patient support system may include a pelvic bolster assembly and a thoracic bolster assembly. Each of the assemblies may be attached to a conventional surgical table frame by the surgical table frame's longitudinal rails. A plurality of adjustment mechanisms and components are provided to allow for easy and safe manipulation of a patient before and during surgery.

Abstract: A reusable modular smoking filtration apparatus includes a tip having a tubular shape with a first end configured with a first coupling feature and a second end configured with a second coupling feature, a removable freshness plug configured to be coupled to the first coupling feature, and a removable cross-hair shaped filter configured to be coupled to the second coupling feature.

Abstract: Systems and methods for treating fluid stasis employ an airstream to move static fluid to one or more natural drainage areas for static fluid. A system for treating fluid stasis includes an airstream nozzle and an airflow generator for supplying an airflow to the airstream nozzle. The airflow nozzle is configured to output an airstream configured to be directed onto a patient to induce shear-thinning of static fluid and movement of static fluid toward one or more natural drainage areas for static fluid.

Abstract: Disclosed herein are surgical retractors and methods of using such surgical retractors where the surgical retractors include a base portion and two retractor blades. The base portion has (a) two extensions, each extension having a receiving area, and (b) and one or more engagement portions. Each retractor blade includes both a blade portion with proximal and distal ends and an arm portion extending from the proximal end of the blade portion. Each arm portion is received by a respective receiving area.

Abstract: A document response production method, the method including: receiving, as input, a document with requests for information, wherein each request for information is a text string; displaying a user interface on the display, the user interface simultaneously displaying a document viewer area, a virtual assistant area, and a text editor area; displaying the received document in the document viewer area; receiving, as input, a selected request for information from among the requests for information; displaying, in the virtual assistant area, one or more automatically selected recommended responses to the selected request for information, and displaying, in the virtual assistant area, one or more other selectable potential responses; based on the selected request for information, automatically generating or suggesting a text string response to the selected request for information; and displaying the text string response in the text editor area.

Abstract: A robotic medical device designed for tissue extraction, featuring a modular construction and motion control assembly. The system includes a robotic arm with multiple joints providing at least three degrees of freedom, a main body with a motorized vacuum pump, and a user interface for operational control. A needle assembly, secured within a removable proximal hub, incorporates a hollow needle with one or more cutting features, a geared wheel for transmitting oscillatory and translational motion, and a luer hub with an O-ring to maintain vacuum pressure. A suction tube connects the needle assembly to the vacuum pump, maintaining negative pressure. The device includes features such as a disposable and reusable elements, quick-connect mechanisms, and integrated sensors for monitoring motion and pressure.

Abstract: Disclosed herein are surgical retractors and methods of using such surgical retractors where the surgical retractors include a base portion and two retractor blades. The base portion has (a) two extensions, each extension having a receiving area, and (b) and one or more engagement portions. Each retractor blade includes both a blade portion with proximal and distal ends and an arm portion extending from the proximal end of the blade portion. Each arm portion is received by a respective receiving area.

Abstract: A patient support system may include a pelvic bolster assembly and a thoracic bolster assembly. Each of the assemblies may be attached to a conventional surgical table frame by the surgical table frame's longitudinal rails. A plurality of adjustment mechanisms and components are provided to allow for easy and safe manipulation of a patient before and during surgery.

Abstract: A retractor assembly that includes a base portion in slidable engagement with two or more retractor arms with at least one of the retractor arms releasably securing a retractor blade configured to be anchored to a bone anchor. The retractor blade includes an elongate blade portion with a retractor engagement portion positioned at the proximal end of the elongate blade portion and an anchor mechanism positioned at the distal end of the elongate blade portion. The anchor mechanism includes a first jaw and second jaw configured to engage the bone implant. When closed around or anchored to the bone implant—which may be a shank of a modular screw system—the components of the modular screw are able to be assembled to the shank without adjusting, loosening, or opening the anchor mechanism.

Abstract: The present disclosure is directed to foamable composition suitable for application as a foam to a body surface area affected by an inflammatory or autoimmune skin or hair disease in a human patient, comprising a foamable carrier component and a propellant component; wherein the foamable carrier component comprises a compound, which is ruxolitinib or deuruxolitinib, or a pharmaceutically acceptable salt of any of the aforementioned. The present disclosure is further directed to a foamable composition suitable for application as a foam to a body surface area affected by an inflammatory or autoimmune skin or hair disease in a human patient, comprising a foamable carrier component and a propellant component; wherein the foamable carrier component comprises a compound, which is ruxolitinib or deuterated ruxolitinib, or a pharmaceutically acceptable salt of any of the aforementioned, a hydroethanolic mixture, an emollient component, one or more C16-18 fatty alcohols, and an emulsifier component.

Abstract: A retractor assembly that includes a base portion in slidable engagement with two or more retractor arms with at least one of the retractor arms releasably securing a retractor blade configured to be anchored to a bone anchor. The retractor blade includes an elongate blade portion with a retractor engagement portion positioned at the proximal end of the elongate blade portion and an anchor mechanism positioned at the distal end of the elongate blade portion. The anchor mechanism includes a first jaw and second jaw configured to engage the bone implant. When closed around or anchored to the bone implant—which may be a shank of a modular screw system—the components of the modular screw are able to be assembled to the shank without adjusting, loosening, or opening the anchor mechanism.