Abstract: Provided are modified arginine deiminase (ADI) proteins, including ADI proteins that comprise one or more substitutions which increase expression in bacteria as insoluble and refoldable inclusion bodies. Also provided are methods of producing the modified ADI proteins, compositions comprising the ADI proteins, and related methods of treating arginine-dependent and related diseases such as cancer.

Abstract: One embodiment of the present invention provides a system for implementing a persistence application programming interface (API) that is platform independent and can make up-calls to business logic. During operation, the system receives a request at the API to execute a command at a persistence tier of an n-tier distributed application. In response to the request, the system determines an entity type for an entity affected by the command. Next, the system identifies a function at a middle tier of the n-tier distributed application that is associated with the entity type and the command, wherein the middle tier includes the business logic. The system then sends an instruction to the middle tier to execute the function. Finally, upon receiving a confirmation at the API that the function executed, the system executes the command at the persistence tier.

Abstract: A method for managing multi-tenancy database access, including receiving credentials from a user associated with a first organization and a second organization, validating the credentials received from the user, logging the user into an access module, generating a first realm ID associated with the credentials and a first access type, generating a second realm ID associated with the credentials and a second access type, storing the first realm ID, the second realm ID, and the credentials in an authentication module, generating a connection request, establishing a connection from the access module to a data repository based on the connection request, generating a first identifier associated with the first realm ID and a second identifier associated with the second realm ID after establishing the connection; and storing the first identifier, the first realm ID, the second identifier, and the second realm ID in the data repository.

Abstract: One embodiment of the present invention provides a system that facilitates managing metadata associated with entities and entity types in a computing system. During operation, the system initializes a global static metadata cache containing global static metadata at the computing system. Next, the system initializes a global dynamic metadata cache containing global dynamic metadata at the computing system. The system then receives a command to initialize a session at the computing system. In response to the command, the system determines a realm for the session, wherein the realm is a virtual private partition of the computing system. The system then initializes a realm-scoped dynamic metadata cache containing realm-scoped dynamic metadata associated with the realm at the computing system. Finally, the system executes operations on the computing system in compliance with the global static metadata, the global dynamic metadata, and the realm-scoped dynamic metadata.

Abstract: One embodiment of the present invention provides a system for implementing a persistence application programming interface (API) that is platform independent and can make up-calls to business logic. During operation, the system receives a request at the API to execute a command at a persistence tier of an n-tier distributed application. In response to the request, the system determines an entity type for an entity affected by the command. Next, the system identifies a function at a middle tier of the n-tier distributed application that is associated with the entity type and the command, wherein the middle tier includes the business logic. The system then sends an instruction to the middle tier to execute the function. Finally, upon receiving a confirmation at the API that the function executed, the system executes the command at the persistence tier.

Abstract: One embodiment of the present invention provides a system that facilitates managing metadata associated with entities and entity types in a computing system. During operation, the system initializes a global static metadata cache containing global static metadata at the computing system. Next, the system initializes a global dynamic metadata cache containing global dynamic metadata at the computing system. The system then receives a command to initialize a session at the computing system. In response to the command, the system determines a realm for the session, wherein the realm is a virtual private partition of the computing system. The system then initializes a realm-scoped dynamic metadata cache containing realm-scoped dynamic metadata associated with the realm at the computing system. Finally, the system executes operations on the computing system in compliance with the global static metadata, the global dynamic metadata, and the realm-scoped dynamic metadata.