Abstract: The invention relates to LAG-3 binding agents, in particular particularly variable heavy chain (VH) sdAbs and bispecific agents that target both LAG-3 and PD-1, and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: The disclosure relates to CD137 binding agents and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: A solvent extraction process for removing poly- and perfluoroalkyl substances (PFAS) from a PFAS laden adsorbent is disclosed. The process comprises introducing a substantially pure solvent at an elevated temperature to a bed of the PFAS laden adsorbent and continuously removing PFAS laden solvent from the adsorbent, wherein the introducing and removing are carried out simultaneously and continuously until a desired amount of PFAS is removed from the adsorbent. Also disclosed is a process for degrading poly- and perfluoroalkyl substances (PFAS) to environmentally benign products. The process comprises providing an aqueous solution containing PFAS at a concentration of greater than 50 ppm; and subjecting the aqueous solution to ultrasound using at least one ultrasonic transducer at a frequency and power and for a time sufficient to degrade substantially all of the PFAS in the solution to carbon dioxide and fluoride.

Abstract: The invention relates to LAG-3 binding agents, in particular variable heavy chain (VH) sdAbs and bispecific agents that target both LAG-3 and PD-1, and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: A water treatment system is disclosed. The water treatment system comprises a filtration module comprising one or more ultrafiltration membrane configured to remove one or more non-PFAS contaminant from a PFAS contaminated water stream to provide a partially purified water stream containing soluble PFAS contaminants. The water treatment system also comprises a sorption module comprising one or more sorption units comprising a sorbent material, the sorption module being in fluid communication with the filtration module and downstream therefrom and configured to remove substantially all PFAS contaminants from the partially purified water stream to provide purified water that is substantially free from PFAS contamination.

Abstract: The invention relates to PD-1 binding agents that do not block the interaction of PD-1 with its ligands, and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: The invention relates to PD-1 binding agents that block the interaction of PD-1 with its ligands, and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: The invention relates to PD-1 binding agents that block the interaction of PD-1 with its ligands, and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: The invention relates to multifunctional PD-1 binding agents and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: The disclosure relates to multispecific agents that simultaneously bind CD137 and PD-1 and which comprise a single domain antibody specific to CD137 and a moiety that binds PD-1, for example a single domain antibody. The disclosure also relates to therapeutic and diagnostic applications of such agents, for example in the treatment of a cancer.

Abstract: The invention relates to multifunctional PD-1 binding agents and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: A water treatment system is disclosed. The water treatment system comprises a filtration module comprising one or more ultrafiltration membrane configured to remove one or more non-PFAS contaminant from a PFAS contaminated water stream to provide a partially purified water stream containing soluble PFAS contaminants. The water treatment system also comprises a sorption module comprising one or more sorption units comprising a sorbent material, the sorption module being in fluid communication with the filtration module and downstream therefrom and configured to remove substantially all PFAS contaminants from the partially purified water stream to provide purified water that is substantially free from PFAS contamination.

Abstract: The invention relates to LAG-3 binding agents, in particular particularly variable heavy chain (VH) sdAbs and bispecific agents that target both LAG-3 and PD-1, and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: The disclosure relates to CD137 binding agents and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: The disclosure relates to agents that simultaneously bind CD137 and PSMA and which comprise a single domain antibody specific to CD137 and a moiety that binds PSMA. The disclosure also relates to therapeutic and diagnostic applications of such agents, for example in the treatment or detection of a cancer.

Abstract: The invention relates to PD-1 binding agents that block the interaction of PD-1 with its ligands, and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: The invention relates to PD-1 binding agents that do not block the interaction of PD-1 with its ligands, and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: The invention relates to multifunctional PD-1 binding agents and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: Erosion electrodes and associated devices, systems, and methods for providing improved performance during a process driven by FEED and facilitated by fluid flushing of a worksite is disclosed. Use of erosion electrodes having varying cross-sectional geometries result in customizable channels, within which the FEED process may proceed, improving efficiency and efficacy of the process as the erosion electrode is advanced longitudinally into a workpiece.

Abstract: A method and apparatus are provided for presenting a reminder for a PIM record when there may be an opportunity for personal interaction regarding the PIM record. The opportunity for personal interaction regarding the PIM record may be identified in response to a trigger condition not associated with the PIM record. In one embodiment, an opportunity for interaction regarding a PIM record may be identified using identification information associated with the trigger condition. In another embodiment, an opportunity for interaction regarding a first PIM record may be identified when there is a contact associated with the first PIM record and a second PIM record, and there is an occurrence of a trigger condition associated with a second PIM record. In some embodiments, the portable electronic device may utilize additional information to identify or verify opportunities for interaction regarding a PIM record.