Patents by Inventor James Leiper

James Leiper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal structure
    Publication number: 20050176060
    Abstract: Structural coordinates obtainable by subjecting a crystal comprising a dimethylarginine dimethylaminohydrolase (DDAH) or a fragment thereof or an argininc deliminase (DI) or a fragment thercof to X-ray diffraction measurements and deducing the structural coordinales from the diffraction measurements arc used to identify, screen, characteristic, design or modify a chemical entity. The chemical entities so generated may be used in methods of Therapy or to identify the presence or absence of a DDAH or DI substrate.
    Type: Application
    Filed: August 17, 2001
    Publication date: August 11, 2005
    Inventors: Neil McDonald, Judith Murray-Rust, James Leiper, Mark McAlister, Patrick John Vallance
  • Dimethylarginine dimethylaminohydrolases
    Publication number: 20050153315
    Abstract: Two dimethylarginine dimethylaminohydrolase (DDAH) genes have been cloned from humans. These genes can be used to screen for inhibitors and activators of activity and/or expression of DDAHs. Inhibitors and activators of activity and/or expression of DDAHs are useful in the treatment of conditions in which abnormal metabolism of nitric oxide is implicated.
    Type: Application
    Filed: October 18, 2004
    Publication date: July 14, 2005
    Applicant: UNIVERSITY COLLEGE LONDON
    Inventors: Patrick Vallance, Ian Charles, James Leiper, Guy Whitley