Abstract: Provided herein are methods of treating the symptoms associated with autism spectrum disorder (ASD) by administering a therapeutically effective amount of a triptan.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: In general, techniques for integration of diverse software applications in i) a co-location facility, ii) communication interconnection network facility, or iii) both, are described. For example, a transformation engine for datacenter colocation and network interconnection products may assist in a dynamic i) transformation of commands and ii) data structure translation as well as data structure transformation between a source application (SA) and a target application (TA) via two or more translation assist templates.

Abstract: At least one user is designated to manage assets including management delegations, access restrictions, and access permissions. Management responsibilities are applied based on business rules and based on a hierarchical model. The hierarchical model enables a well-defined logical flow of delegations and restrictions with pruning capability. User groups, asset groups, asset trees and asset permissions may be defined. The designated user can manage a single asset or all assets or a subset of assets. An asset may belong to one or more asset groups.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: A performance, analytics and auditing (PAA) system is configured to operate with a complex web application including a portal application and its sub systems non-intrusively. The PAA system includes a first component configured to capture behavior-related information from the portal application, a second component configured to capture performance-related information from the portal application, a third component configured to capture auditing-related information from the portal application. The PAA system is further configured to start or stop with minimal impact on the portal application, wherein the PAA system is coded using Aspect Oriented Programming (AOP) and able to collect information from multiple threads.

Abstract: Integration of diverse software applications in i) a co-location facility, ii) communication interconnection network facility or ii) both. A transformation engine for datacenter colocation and network interconnection products may assist in a dynamic i) transformation of commands and ii) data structure translation as well as data structure transformation between a source application (SA) and a target application (TA) via two or more translation assist templates. The translation assist templates correlate to various combinations of the SAs, TAs, and the colocation or the network interconnection products. The network transformation engine may generate a new translation assist template when information regarding a new or updated application or product is loaded into a database.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: A logical customer organization model is applied to group the individual agreements into separate logical customer organizations, wherein the groupings can be region based groupings, organization groupings and departmental groupings. Unified login identification (ID) model is applied to enable a first user to login to a portal using a first login ID to access a first asset in a first asset group according to a first logical customer organization. The unified login ID model enables the first user to use the same first login ID to access a second asset in the first asset group according to the first logical customer organization. The unified login ID model also enables the first user to login to the portal using a second login ID to access one or more assets in a second asset group according to a second logical customer organization. Each of the first and second logical customer organization may be associated with one or more asset groups and one or more user groups.

Abstract: At least one user is designated to manage assets including management delegations, access restrictions, and access permissions. Management responsibilities are applied based on business rules and based on a hierarchical model. The hierarchical model enables a well-defined logical flow of delegations and restrictions with pruning capability. User groups, asset groups, asset trees and asset permissions may be defined. The designated user can manage a single asset or all assets or a subset of assets. An asset may belong to one or more asset groups.

Abstract: A logical customer organization model is applied to group the individual agreements into separate logical customer organizations, wherein the groupings can be region based groupings, organization groupings and departmental groupings. Unified login identification (ID) model is applied to enable a first user to login to a portal using a first login ID to access a first asset in a first asset group according to a first logical customer organization. The unified login ID model enables the first user to use the same first login ID to access a second asset in the first asset group according to the first logical customer organization. The unified login ID model also enables the first user to login to the portal using a second login ID to access one or more assets in a second asset group according to a second logical customer organization. Each of the first and second logical customer organization may be associated with one or more asset groups and one or more user groups.

Abstract: A performance, analytics and auditing (PAA) system is configured to operate with a complex web application including a portal application and its sub systems non-intrusively. The PAA system includes a first component configured to capture behavior-related information from the portal application, a second component configured to capture performance-related information from the portal application, a third component configured to capture auditing-related information from the portal application. The PAA system is further configured to start or stop with minimal impact on the portal application, wherein the PAA system is coded using Aspect Oriented Programming (AOP) and able to collect information from multiple threads.

Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.

Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.

Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.

Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.

Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers. A variety of marker genes are provided, wherein changes in the levels of expression of one or more of the marker genes is correlated with the presence of breast cancer.

Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human ovarian cancers. A variety of novel markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of ovarian cancer.