Abstract: A headgear assembly for a full-face under-nose respiratory mask can include a flexible headgear connector element. A free end of each of upper straps of the headgear is coupled to the headgear connector element, which is configured to extend laterally across and be removably fastened to a frame of the respiratory mask below a tip of a user's nose. A respiratory mask assembly can include a bias vent in communication with a cushion module and configured to allow air to be exhausted from the cushion module through the bias vent. The bias vent can be provided with a diffuser including a diffuser material configured to extend over the bias vent. The diffuser material provides a tortuous air path from the bias vent through the diffuser. The bias vent and/or the diffuser can be provided on various components of the assembly.

Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.

Abstract: A method for efficiently generating a plurality of personalized email strategies and corresponding personalized emails for campaign recipients is disclosed. Multi-dimensional data comprising account data, recipient data, and seller data is received from one or more data sources. The received multi-dimensional data is processed to extract relevant features. A dynamic feature hierarchy is generated using the extracted features. A pre-trained machine learning model is fine-tuned using the dynamic feature hierarchy to generate email strategies, wherein model parameters are adjusted based on the hierarchy during fine-tuning. A plurality of email strategies is generated for each recipient by applying the fine-tuned model's recommendations. An email strategy is selected from the plurality of strategies based on one or more factors. A personalized email corresponding to the selected email strategy is generated. The personalized email and the selected email strategy used to generate it are displayed to a user.

Abstract: The present disclosure provides novel nucleic acid-guided nucleases and methods of using the nucleases for genome editing. The present disclosure further provides a system for editing a target region in a genome comprising a nucleic acid-guided nuclease, a heterologous guide nucleic acid for complexing with the nucleic acid-guided nuclease, and an editing polynucleotide configured to bind to the target region.

Abstract: Embodiments are disclosed for a generating graph representations of neural networks to be used as input for one or more metanetworks. Architectural information can be extracted from a neural network and used to generate graph a representation. A subgraph can be generated for each layer of the neural network, where each subgraph includes nodes that correspond to neurons and connecting edges that correspond to weights. Each layer of the neural network can be associated with a bias node that is connected to individual nodes of that layer using edges representing bias weights. Various types of neural networks and layers of neural networks can be represented by such graphs, which are then used as inputs for metanetworks. The subgraphs can be combined into a comprehensive graph representation of the neural network, which can be provided as input to a metanetwork to generate network parameters or perform another such operation.

Abstract: A coupler including a fitting for mounting to externally threaded reinforcing bar for use in concrete construction, the fitting including a body having a portion with an internal thread for engagement with the thread of the reinforcing bar, wherein the internal thread has an asymmetric thread form having an outer ramped portion and an inner ramped portion, the outer ramped portion being inclined to a central axis of the coupler at a first angle, the inner ramped portion being inclined to the central axis of the coupler at a second angle, the first angle being smaller in magnitude than the second angle.

Abstract: The technology described herein provides an automated software-testing platform that functions in an undefined action space. The technology described herein starts with an undefined action space but begins to learn about the action space through random exploration. Both the action taken during testing and the resulting state may be communicated to a centralized testing service. The technology described herein also mines the action telemetry data and state telemetry data to identify action patterns that produce a sought after result. Once a plurality of action patterns is identified and, at least, a partial model of the action space is built, the testing on the test machines may be split into random test mode, replay test mode, and a pioneering test mode.

Abstract: In some embodiments there is provided a headgear assembly for a full-face under-nose respiratory mask comprising a strap assembly including a rear panel, a crown strap, a pair of opposing upper side straps, and a pair of opposing lower side straps. The assembly further comprises a flexible headgear connector element, wherein a free end of each of the upper straps is coupled to the headgear connector element, and wherein the headgear connector element is configured to extend laterally across and be removably fastened to a frame of the respiratory mask below a tip of a user's nose. There is also provided a respiratory mask assembly comprising a mask frame and a cushion module, the mask frame comprising a breathing gas inlet configured to receive a supply of breathable gas and to deliver the breathable gas to the cushion module, the cushion module being configured to form a seal with a user's face.

Abstract: Embodiments of a method of modulating a potency level phenotype of a source population of cells include culturing the source cell population in a liquid medium within a cell culture incubator, the incubator is configured to independently regulate one or more variable parameters of gaseous conditions within the incubator, the more than one variable atmospheric parameters within the incubator being regulated independently of each other and independently of ambient external gaseous conditions. The method further includes regulating the one or more variable parameters of the gaseous condition within the incubator such that at least one of the one or more variable parameter differs from an ambient level of the respective variable parameter, and as a consequence of such difference from ambient conditions, the subset population is driven from a first potency level phenotype to a second potency level phenotype.

Abstract: Embodiments of a cell culture incubator system provided herein have two or more individual incubators and atmospheric regulation system configured to regulate atmospheric conditions within the environmental chamber of each individual incubator. The atmospheric regulation system has a single integrated controller system that controls atmospheric regulation of each of the individual incubators independently of the one or more other individual incubators. Atmospheric conditions within each of the individual incubators include at least the oxygen level and the total gas pressure, which are regulated independently of each other.

Abstract: Embodiments of a method of modulating a potency level phenotype of a source population of cells include culturing the source cell population in a liquid medium within a cell culture incubator, the incubator is configured to independently regulate one or more variable parameters of gaseous conditions within the incubator, the more than one variable atmospheric parameters within the incubator being regulated independently of each other and independently of ambient external gaseous conditions. The method further includes regulating the one or more variable parameters of the gaseous condition within the incubator such that at least one of the one or more variable parameter differs from an ambient level of the respective variable parameter, and as a consequence of such difference from ambient conditions, the subset population is driven from a first potency level phenotype to a second potency level phenotype.

Abstract: Embodiments of the provided technology relate to a gas flow and liquid flow regulation system within a cell culture instrument. Embodiments of the gas and liquid flow regulation system include a pressurizable gas-mixing chamber, a cell culture compartment that includes a cell culture vessel having and a gas space, and a gas flow system. The gas flow system is driven by gas pressure, and is adaptable to provide an atmospheric condition of hypoxia and hyperbaric pressure within the cell culture compartment. The liquid flow regulation system is driven by hydraulic pressure.

Abstract: Example embodiments of the described technology provide an apparatus for testing an electrochemical system. The apparatus may comprise a testing module electrically coupled to the electrochemical system. The testing module may comprise a discharge circuit configured to draw current from the electrochemical system at a plurality of different rates. The discharge circuit may be configured to continuously draw current from the electrochemical system once a test of the electrochemical system is commenced. The apparatus may also comprise a measurement module which may be configured to measure voltage across terminals of the electrochemical system and current drawn from the electrochemical system during the test. The apparatus may also comprise a processor. The processor may be configured to compensate at least in part the measured voltage for voltage drift which was generated by continuously drawing current from the electrochemical system.

Abstract: The present disclosure relates to a method of modulating a phenotype a source population of cells to assume a desired phenotype. The method includes culturing the source cell population within an incubator configured to regulate the variable atmospheric parameters of oxygen level and total atmospheric pressure level.

Abstract: Embodiments of a method of modulating a potency level phenotype of a source population of cells include culturing the source cell population in a liquid medium within a cell culture incubator, the incubator is configured to independently regulate one or more variable parameters of gaseous conditions within the incubator, the more than one variable atmospheric parameters within the incubator being regulated independently of each other and independently of ambient external gaseous conditions. The method further includes regulating the one or more variable parameters of the gaseous condition within the incubator such that at least one of the one or more variable parameter differs from an ambient level of the respective variable parameter, and as a consequence of such difference from ambient conditions, the subset population is driven from a first potency level phenotype to a second potency level phenotype.

Abstract: A method includes generating motion data by receiving a gyroscope data from a gyroscope sensor, performing integration using the gyroscope data and generating an integrated gyroscope data using a first processor. The method further includes receiving a data from one or more sensors, other than the gyroscope sensor, and performing sensor fusion using the integrated gyroscope data and the data to generate motion data using a second processor.

Abstract: Embodiments of the invention relate to a cell culture incubator having a gas flow regulation system that exerts control over atmospheric parameters within the incubator. Particular embodiments include an enclosed environmental chamber and a control unit operably linked thereto, the control unit having an oxygen module and a pressure module. Control unit embodiments, by way of these modules, are configured to regulate both oxygen partial pressure and total gas pressure within the enclosed environmental chamber. Embodiments of the control unit are adapted (a) to provide instructions to the oxygen module to regulate an oxygen level to an instructed hypoxic oxygen level and (b) to provide instructions to the pressure module to regulate total gas pressure to an instructed positive pressure level. The regulation of oxygen to the instructed hypoxic level prevails despite an oxygen partial pressure-increasing effect of the positive pressure condition associated with the instructed positive pressure level.

Abstract: Embodiments of the invention relate to a cell culture incubator having a gas flow regulation system that exerts control over atmospheric parameters within the incubator. Particular embodiments include an enclosed environmental chamber and a control unit operably linked thereto, the control unit having an oxygen module and a pressure module. Control unit embodiments, by way of these modules, are configured to regulate both oxygen partial pressure and total gas pressure within the enclosed environmental chamber. Embodiments of the control unit are adapted (a) to provide instructions to the oxygen module to regulate an oxygen level to an instructed hypoxic oxygen level and (b) to provide instructions to the pressure module to regulate total gas pressure to an instructed positive pressure level. The regulation of oxygen to the instructed hypoxic level prevails despite an oxygen partial pressure-increasing effect of the positive pressure condition associated with the instructed positive pressure level.

Abstract: Embodiments of a method of modulating a potency level phenotype of a source population of cells include culturing the source cell population in a liquid medium within a cell culture incubator, the incubator is configured to independently regulate one or more variable parameters of gaseous conditions within the incubator, the more than one variable atmospheric parameters within the incubator being regulated independently of each other and independently of ambient external gaseous conditions. The method further includes regulating the one or more variable parameters of the gaseous condition within the incubator such that at least one of the one or more variable parameter differs from an ambient level of the respective variable parameter, and as a consequence of such difference from ambient conditions, the subset population is driven from a first potency level phenotype to a second potency level phenotype.