Abstract: A vehicle height sensing system for determining and indicating to a user whether a vehicle height exceeds a clearance height of an overhead obstruction includes a display panel is configured to be visible from a vehicle when the vehicle is driving toward the overhead obstruction. A measurement device is in communication with and operationally coupled to the display panel. The measurement device measures the vehicle height and communicates the vehicle height to the display panel. The measurement device includes a pair of poles that are positioned on opposite shoulders of a roadway and are aligned with each other across the roadway. Each of the pair of poles is in communication with the other to determine the vehicle height. The display panel provides a positive indicium when the vehicle height is less than the clearance height and a negative indicium when the vehicle height is greater than the clearance height.

Abstract: A vehicle height sensing system for determining and indicating to a user whether a vehicle height exceeds a clearance height of an overhead obstruction includes a display panel is configured to be visible from a vehicle when the vehicle is driving toward the overhead obstruction. A measurement device is in communication with and operationally coupled to the display panel. The measurement device measures the vehicle height and communicates the vehicle height to the display panel. The measurement device includes a pair of poles that are positioned on opposite shoulders of a roadway and are aligned with each other across the roadway. Each of the pair of poles is in communication with the other to determine the vehicle height. The display panel provides a positive indicium when the vehicle height is less than the clearance height and a negative indicium when the vehicle height is greater than the clearance height.

Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.

Abstract: Three-dimensional (3D) printing systems include a 3D printer that includes a print bed that has one or more walls arranged to enclose a basin configured to contain a printing material. A compression plate is configured to fit slidably within, or on top surfaces of, the one or more walls of the print bed. A bottom plate forms a base of the basin and is configured to fit slidably within the one or more walls of the print bed. An elevation controller moves one or both of the compression plate and the bottom plate towards each other to apply a specified compressive force on printing material within the basin. The compression plate and the bottom plate together seal the basin sufficiently to avoid leakage of the print material from the basin.

Abstract: A breakseal providing desired compliance characteristics for a reliable seal between the fitment of a liquid dispenser and the breakseal. A compliant material is provided on the non-wetted face of the breakseal, enabling compliance of the breakseal on a wetted face for sealing between the breakseal and the mating component. The breakseal may also include raised features on segments that are separated after rupturing that prevent or mitigate scoring of O-ring seals upon probe insertion. A wiping feature that provides redundant sealing between the breakseal and a mating cap or other mating connection may also be incorporated into the breakseal. The breakseal can also include a flat on an outer perimeter that may serve as a gate for injection molding, so that any gate vestige from the molding process will not protrude beyond the outer diameter of the breakseal to cause unwanted interference between the breakseal and the mating connection.

Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.

Abstract: A breakseal providing desired compliance characteristics for a reliable seal between the fitment of a liquid dispenser and the breakseal. A compliant material is provided on the non-wetted face of the breakseal, enabling compliance of the breakseal on a wetted face for sealing between the breakseal and the mating component. The breakseal may also include raised features on segments that are separated after rupturing that prevent or mitigate scoring of O-ring seals upon probe insertion. A wiping feature that provides redundant sealing between the breakseal and a mating cap or other mating connection may also be incorporated into the breakseal. The breakseal can also include a flat on an outer perimeter that may serve as a gate for injection molding, so that any gate vestige from the molding process will not protrude beyond the outer diameter of the breakseal to cause unwanted interference between the breakseal and the mating connection.

Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.

Abstract: This invention relates to methods, articles and compositions useful in detecting target substances in an alcoholic preservative solution, and for identifying sensors useful for binding to such targets. The methods allow for the simultaneous performance of sufficient fixation of a sample and binding of a detectable sensor to a target of interest in the sample. In one aspect, a method is provided that comprises contacting a sample suspected of containing a target with a detectable sensor molecule known to bind to such target in an alcoholic preservative solution. The method maybe performed in multiplex form to permit simultaneous analysis of a plurality of targets. Methods for identifying a sensor capable of binding to a desired target in an alcoholic preservative solution are also provided. An alcoholic preservative solution comprising one or more such detectable sensors is also provided. Also provided is a sample comprising a bound sensor provided by such a process.

Abstract: Three-dimensional (3D) printing systems include a 3D printer that includes a print bed that has one or more walls arranged to enclose a basin configured to contain a printing material. A compression plate is configured to fit slidably within, or on top surfaces of, the one or more walls of the print bed. A bottom plate forms a base of the basin and is configured to fit slidably within the one or more walls of the print bed. An elevation controller moves one or both of the compression plate and the bottom plate towards each other to apply a specified compressive force on printing material within the basin. The compression plate and the bottom plate together seal the basin sufficiently to avoid leakage of the print material from the basin.

Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.

Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.

Abstract: Methods, systems and computer readable media for processing one or more biological specimens carried by specimen slides. Images of objects in a specimen are acquired and objects of interest in the acquired images are identified. Additional images of identified objects of interest may be acquired at multiple wavelengths. Cellular features of objects of interest are extracted from images and may be used for classifying the specimen, e.g., as normal or suspicious/abnormal, based a probabilistic model that utilizes the extracted features.

Abstract: The invention relates to a cell fixative that can be used in the preparation of slides for investigation by microscopy techniques. In particular the present invention provides a cell fixative that contains a light curable mounting medium.

Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.

Abstract: A cytological material sample collection device comprises a cylinder having a longitudinal bore extending there through. The sample collection device further comprises a filter membrane configured for collecting a layer of cytological material when the bore is subjected to negative pressure. The sample collection device further comprises a drip guard disposed on the cylinder proximal to the membrane. The drip guard may include at least one access port in fluid communication with the bore. The sample collection device may further comprise a chuck that selectively mates with the cylinder, so that, after usage of the sample collection device, the cylinder can be discarded, while the chuck can be reused with subsequent cylinders.

Abstract: This invention relates to methods, articles and compositions useful in detecting target substances in an alcoholic preservative solution, and for identifying sensors useful for binding to such targets. The methods allow for the simultaneous performance of sufficient fixation of a sample and binding of a detectable sensor to a target of interest in the sample. In one aspect, a method is provided that comprises contacting a sample suspected of containing a target with a detectable sensor molecule known to bind to such target in an alcoholic preservative solution. The method maybe performed in multiplex form to permit simultaneous analysis of a plurality of targets. Methods for identifying a sensor capable of binding to a desired target in an alcoholic preservative solution are also provided. An alcoholic preservative solution comprising one or more such detectable sensors is also provided. Also provided is a sample comprising a bound sensor provided by such a process.

Abstract: The invention relates to methods for detecting and identifying potential biomarkers of high-grade cervical dysplasia in an individual human subject. The invention also relates to newly discovered biomarkers, as set forth in Tables 1-4 herein, which are associated with the dysplastic state of cervical cells. It has been discovered that a differential level of expression of any of these markers or combination of these markers correlates with a dysplastic condition in a human subject, e.g., a patient.

Abstract: Methods, systems and computer readable media for processing one or more biological specimens carried by specimen slides. Images of objects in a specimen are acquired and objects of interest in the acquired images are identified. Additional images of identified objects of interest may be acquired at multiple wavelengths. Cellular features of objects of interest are extracted from images and may be used for classifying the specimen, e.g., as normal or suspicious/abnormal, based a probabilistic model that utilizes the extracted features.