Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticaccaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.

Abstract: The present disclosure provides ubonodin peptides, pharmaceutical formulations comprising ubonodin peptides and nucleic acids encoding ubonodin peptides. The disclosure also provides methods of treating Burkholderia infections in a subject in need thereof utilizing the described ubonodin peptides and pharmaceutical formulations.

Abstract: A system for cooling a heat generating component of a vehicle. The system includes a blower of a vehicle heating, ventilation, and air conditioning (HVAC) system. An air duct extends from the blower to the heat generating component to cool the heat generating component.

Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.

Abstract: A system for cooling a heat generating component of a vehicle. The system includes a blower of a vehicle heating, ventilation, and air conditioning (HVAC) system. An air duct extends from the blower to the heat generating component to cool the heat generating component.

Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticaccaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.

Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticcacaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticcacaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.

Abstract: The present disclosure provides a casing for an air conditioning unit including a main body, a door, a passing defining member, and a drain channel. The main body includes a fresh-air passage and a recirculation-air passage. The recirculation-air passage is positioned below the fresh-air passage. The door selectively opens and closes a communication hole through which the fresh-air passage and the recirculation-air passage are in fluid communication with each other. The passage defining member is disposed upstream of the communication hole and defines a lower side of the fresh-air passage. The drain channel extends from the passage defining member to a space outside of the recirculation-air passage to discharge condensed water generated in the fresh-air passage.

Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.

Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.

Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticcacaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticcacaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.

Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticaccaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.

Abstract: The present disclosure provides a casing for an air conditioning unit including a main body, a door, a passing defining member, and a drain channel. The main body includes a fresh-air passage and a recirculation-air passage. The recirculation-air passage is positioned below the fresh-air passage. The door selectively opens and closes a communication hole through which the fresh-air passage and the recirculation-air passage are in fluid communication with each other. The passage defining member is disposed upstream of the communication hole and defines a lower side of the fresh-air passage. The drain channel extends from the passage defining member to a space outside of the recirculation-air passage to discharge condensed water generated in the fresh-air passage.

Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.

Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.

Abstract: A fastening device for securing a first component to a second component includes a latch coupled with the first component and a catch coupled with the second component. The fastening device further includes a convex portion formed with one of the latch and the catch and a concave portion formed with the other of the latch and the catch. The catch is configured to engage with the latch when the concave portion receives the convex portion.

Abstract: A dual joint block for pressing a seal against an air conditioner thermal expansion valve housing. The dual joint block includes a body having an inner face and an outer face. The body defines a first aperture and a second aperture. The first aperture extends through the body between the inner face and the outer face. The first aperture is configured to completely surround a first conduit extending therethrough. The second aperture extends through the body between the inner face and the outer face, and is configured to completely surround a second conduit extending therethrough.

Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticaccaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.

Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.

Abstract: A dual joint block for pressing a seal against an air conditioner thermal expansion valve housing. The dual joint block includes a body having an inner face and an outer face. The body defines a first aperture and a second aperture. The first aperture extends through the body between the inner face and the outer face. The first aperture is configured to completely surround a first conduit extending therethrough. The second aperture extends through the body between the inner face and the outer face, and is configured to completely surround a second conduit extending therethrough.