Patents by Inventor James Linton

James Linton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and Methods for Treating Stress Urinary Incontinence
    Publication number: 20240148485
    Abstract: The disclosure provides improved methods and devices to create a hammock effect to stabilize the urethra without creating an incision in the abdomen or the vagina, and without using a surgical mesh. Such implementations can also leave no permanent material in the body. The simplicity afforded by such procedures and methods permits treatment of patients on an outpatient basis, and avoids risks and disadvantages associated with the installation of a permanent mesh.
    Type: Application
    Filed: November 30, 2023
    Publication date: May 9, 2024
    Inventors: Jon I. Einarsson, James Bleck, John Aho, Jonathan Towle, Aidan Linton
  • Compositions and methods for programmable sensing and control through combinatorial molecular interactions
    Patent number: 11604198
    Abstract: Methods and compositions are provided for the selective activation of a BMP-dependent response in certain cell types. Methods include identifying a ligand or ligand combinations as well as cell receptor profiles that result in selectively activating a ligand-dependent response through interactions with ligand receptors on a first cell type that do not activate the ligand-dependent response in a second cell type.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: March 14, 2023
    Assignee: California Institute of Technology
    Inventors: Yaron E. Antebi, James Linton, Michael Elowitz, Heidi Klumpe
  • IN SITU READOUT OF DNA BARCODES
    Publication number: 20220396833
    Abstract: Disclosed herein include systems, methods, compositions, and kits for in situ readout of barcodes, such as DNA barcodes. Barcode constructs containing a promoter (e.g., a phage promoter) that is inactive in live cells can be integrated in the genomes of cells. Cells can be fixed, and phage RNA polymerase can be used for transcription of the barcode to RNA transcripts. The RNA transcripts can be detected using, for example, fluorescent imaging and used to determine barcode sequences.
    Type: Application
    Filed: August 4, 2022
    Publication date: December 15, 2022
    Inventors: Amjad Askary, Michael B. Elowitz, Mark W. Budde, Carlos Lois, Luis Sanchez Guardado, Long Cai, James Linton
  • In situ readout of DNA barcodes
    Patent number: 11421273
    Abstract: Disclosed herein include systems, methods, compositions, and kits for in situ readout of barcodes, such as DNA barcodes. Barcode constructs containing a promoter (e.g., a phage promoter) that is inactive in live cells can be integrated in the genomes of cells. Cells can be fixed, and phage RNA polymerase can be used for transcription of the barcode to RNA transcripts. The RNA transcripts can be detected using, for example, fluorescent imaging and used to determine barcode sequences.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: August 23, 2022
    Assignee: California Institute of Technology
    Inventors: Amjad Askary, Michael B. Elowitz, Mark W. Budde, Carlos Lois, Luis Sanchez Guardado, Long Cai, James Linton
  • IN SITU READOUT OF DNA BARCODES
    Publication number: 20200172968
    Abstract: Disclosed herein include systems, methods, compositions, and kits for in situ readout of barcodes, such as DNA barcodes. Barcode constructs containing a promoter (e.g., a phage promoter) that is inactive in live cells can be integrated in the genomes of cells. Cells can be fixed, and phage RNA polymerase can be used for transcription of the barcode to RNA transcripts. The RNA transcripts can be detected using, for example, fluorescent imaging and used to determine barcode sequences.
    Type: Application
    Filed: December 2, 2019
    Publication date: June 4, 2020
    Inventors: Amjad Askary, Michael B. Elowitz, Mark W. Budde, Carlos Lois, Luis Sanchez Guardado, Long Cai, James Linton
  • COMPOSITIONS AND METHODS FOR PROGRAMMABLE SENSING AND CONTROL THROUGH COMBINATORIAL MOLECULAR INTERACTIONS
    Publication number: 20200116717
    Abstract: Methods and compositions are provided for the selective activation of a BMP-dependent response in certain cell types. Methods include identifying a ligand or ligand combinations as well as cell receptor profiles that result in selectively activating a ligand-dependent response through interactions with ligand receptors on a first cell type that do not activate the ligand-dependent response in a second cell type.
    Type: Application
    Filed: December 2, 2019
    Publication date: April 16, 2020
    Inventors: Yaron E. Antebi, James Linton, Michael Elowitz, Heidi Klumpe
  • Compositions and methods for programmable sensing and control through combinatorial molecular interactions
    Patent number: 10527631
    Abstract: Methods and compositions are provided for the selective activation of a BMP-dependent response in certain cell types. Methods include identifying a ligand or ligand combinations as well as cell receptor profiles that result in selectively activating a ligand-dependent response through interactions with ligand receptors on a first cell type that do not activate the ligand-dependent response in a second cell type.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: January 7, 2020
    Assignee: California Institute of Technology
    Inventors: Yaron E. Antebi, James Linton, Michael Elowitz, Heidi Klumpe
  • Compositions and methods for programmable sensing and control through combinatorial molecular interactions
    Publication number: 20180172704
    Abstract: Methods and compositions are provided for the selective activation of a BMP-dependent response in certain cell types. Methods include identifying a ligand or ligand combinations as well as cell receptor profiles that result in selectively activating a ligand-dependent response through interactions with ligand receptors on a first cell type that do not activate the ligand-dependent response in a second cell type.
    Type: Application
    Filed: December 19, 2017
    Publication date: June 21, 2018
    Inventors: Yaron E. Antebi, James Linton, Michael Elowitz
  • GENETIC ANALYSIS OF CELLS
    Publication number: 20100179310
    Abstract: Some aspects relate to methods for genetic analysis of selected cells from within a heterogeneous population of cells. The population of cells first can be partitioned. Selected cells are identified by imaging, and then specifically targeted and lysed by irradiation with an energy beam, resulting in specific release of their cellular contents into the culture medium. The culture medium then can be sampled and assayed for the desired nucleic acids.
    Type: Application
    Filed: January 8, 2010
    Publication date: July 15, 2010
    Applicant: Cyntellect, Inc.
    Inventors: Fredrik Kamme, Gary Bright, Gustaf Angelborg, James Linton, Manfred Koller