Abstract: An optical system including a dual-layer microelectromechanical systems (MEMS) device, and methods of fabricating and operating the same are disclosed. Generally, the MEMS device includes a substrate having an upper surface; a top modulating layer including a number of light modulating micro-ribbons, each micro-ribbon supported above and separated from the upper surface of the substrate by spring structures in at least one lower actuating layer; and a mechanism for moving one or more of the micro-ribbons relative to the upper surface and/or each other. The spring structures are operable to enable the light modulating micro-ribbons to move continuously and vertically relative to the upper surface of the substrate while maintaining the micro-ribbons substantially parallel to one another and the upper surface of the substrate. The micro-ribbons can be reflective, transmissive, partially reflective/transmissive, and the device is operable to modulate a phase and/or amplitude of light incident thereon.

Abstract: Power management operations are performed by devices communicating using multiple bands simultaneously where a first wireless band can be used to send and receive power management control frames for use on a second wireless band of a wireless network. In this way, a device that is in a sleep or dose power management state on a first band can be instructed to enter an awake power management state on the first band based on a communication received over a second band that is currently active and receiving data. Embodiments of the present invention enable power to be conserved when a band is not currently being used, or when there is no more data available (buffered) for a specific band.

Abstract: Communications between an access point (AP) and a non-AP station (STA) are established in a plurality of frequency segments within a basic service set (BSS) bandwidth or on at least a first link and a second link. An extreme-high-throughput (EHT) subchannel selective transmission (SST) operation is performed between the AP and the non-AP STA in the plurality of frequency segments or on the first link and the second link. A trigger-enabled target wake time (TWT) session period (SP) for the EHT SST operation by either indicating one of the plurality of frequency segments as containing a resource unit (RU) allocation addressed to the non-AP STA or indicating one of the first link and the second link on which an operating frequency segment is located during the TWT SP.

Abstract: Disclosed are compositions and methods for targeted treatment of glioblastoma multiforme (GBM). In particular, chimeric antigen receptor (CAR) polypeptides are disclosed that can be used with adoptive cell transfer to target and kill Glioblastoma Stem Cells (GSCs). Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with Glioblastoma Stem Cells (GSCs) that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.

Abstract: A surgical instrument is disclosed herein. The surgical instrument can include an end effector that includes jaws configured to transition between an opened condition and a closed condition, a plurality of electrodes positioned within the jaws of the end effector, a control circuit, and a memory configured to store an algorithm configured to cause the control circuit to determine an impedance signal based on signals received from the plurality of electrodes, detect a media positioned between the jaws of the end effector based on the determined impedance signal, determine a position of the detected media based on the received signals, and generate an alert associated with the detected media and the determined position.

Abstract: The present invention relates to isolated polypeptides having pectinase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Abstract: Authenticating a mobile user device with a mobile network operator in advance of an MNO authentication request from the mobile user device can be done by a satellite network sending an authentication request to the MNO system, obtaining a set of authentication vectors related to the mobile user device, storing them into a proxy home location register, receiving the MNO authentication request from the mobile user device, generating an authentication request response based on the authentication vectors, sending the authentication request response to the mobile user device, receiving an authentication response including a received signed response, comparing the received signed response with the stored signed response, and if the received signed response and stored signed response match, deem that to be a successful authentication, add an MNO location update message to a request queue and forward the MNO location update message to the MNO system over the channel when available.

Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.

Abstract: Methods for determining the presence of an unmeasured chemical in an environment can include receiving a plurality of sensor readings from a plurality of chemical sensors, wherein each chemical sensor of the plurality of chemical sensors is configured to detect a different chemical, determining a cross-sensitivity pattern from one or more unmeasured chemicals in the plurality of sensor readings, comparing the cross-sensitivity pattern with one or more known chemical patterns, determining that the cross-sensitivity pattern matches at least one of the one or more known chemical patterns that correspond to one or more chemicals, and identifying one or more unmeasured chemicals based on determining that the cross-sensitivity pattern matches the at least one of the one or more known chemical patterns.

Abstract: Mechanisms are provided for compartmental epidemiological computer modeling based on mobility data. Machine learning training of an isolation rate prediction computer model is performed to generate a trained isolation rate prediction model that predicts an isolation rate of a biological population. Isolation data is received which comprises data indicating a measure of mobility of the biological population. The trained isolation rate prediction model is executed on input features extracted from the isolation data to generate a predicted isolation rate. A compartmental epidemiological computer model, comprising a plurality of compartments representing states of a population with regard to an infectious disease, is executed to simulate a progression of the infectious disease and flows of portions of the population from between compartments in the compartmental epidemiological computer model are controlled based on the predicted isolation rate.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Embodiments of the present invention provide an apparatus and method for a MAP wireless network that includes a collaborative channel sounding measurement phase to determine channel state information between devices (e.g., the channel state between an STA and a collaborative AP) for efficient configuration of the MAP wireless network and to improve the performance of the MAP wireless networks. The wireless AP and wireless STAs associated with the collaborative APs can simultaneously transmit by applying collaborative beamforming where the interferences between channels nullify each other (e.g., nulling), and the beamforming is performed based on a sounding phase performed by the collaborative APs.

Abstract: An access point (AP) and a station (STA) communicate with each other, with the AP indicating to the STA either or both of a preamble detection (PD) channel and a signaling (SIG) content channel and with the STA being initially monitoring a primary frequency segment of a plurality of frequency segments in an operating bandwidth of the AP. A downlink (DL) or triggered uplink (UL) communication is performed between the AP and the STA during a transmission opportunity (TXOP) such that: (i) during the TXOP, the STA monitors a preamble on the PD channel and decodes a SIG content on the SIG content channel; and (ii) after an end of the TXOP, the STA switches to the primary frequency segment.

Abstract: Coating compositions comprise: a curable compound comprising: a core chosen from a C6 carbocyclic aromatic ring, a C2-5 heterocyclic aromatic ring, a C9-30 fused carbocyclic aromatic ring system, a C4-30 fused heterocyclic aromatic ring system, C1-20 aliphatic, and C3-20 cycloaliphatic, and three or more substituents of formula (1) wherein at least two substituents of formula (1) are attached to the aromatic core; provided that no substituents of formula (1) are in an ortho position to each other on the same aromatic ring of the core; a polymer; and one or more solvents, wherein the total solvent content is from 50 to 99 wt % based on the coating composition.

Abstract: The present disclosure is directed to a computer system and techniques for automatically annotating objects in map data used for navigating an autonomous vehicle. Generally, the computer system is configured to obtain LiDAR data points for an environment around an autonomous vehicle, project the LiDAR data points onto image data, detect a target object in the image data, extract a subset of the LiDAR data points that corresponds to the detected target object, register the detected target object in map data if the extracted subset of the LiDAR data points satisfies registration criteria, and navigate the autonomous vehicle in the environment according to the map data.

Abstract: Polyphosphate compositions are produced by a process that includes the steps of continuously introducing a phosphate compound into a polymerization vessel, polymerizing the phosphate compound at a temperature of 250-450° C. for a time period sufficient to form the polyphosphate composition, and continuously discharging the polyphosphate composition from the polymerization vessel. The phosphate compound can be fed to the polymerization vessel in the form of an aqueous slurry containing 5-50 wt. % of the phosphate compound. Resulting polyphosphate compositions often contain at least 8 wt. % of a polyphosphate and less than 35 wt. % of the phosphate compound.

Abstract: Systems and methods for generating one or more single crystal monolayers from two-dimensional van der Waals crystals are disclosed herein. Example methods include providing a bulk material including a plurality of van der Waals crystal layers, and exfoliating one or more single crystal monolayers of van der Waals crystal from the bulk material by applying a flexible and flat metal tape to a surface of the bulk material. In certain embodiments, the one or more single crystal monolayers can be assembled into an artificial lattice. The present disclosure also provides techniques for manufacturing flexible and flat metal tape for generating one or more single crystal monolayers from two-dimensional van der Waals crystals. The present disclosure also provides compositions for creating a macroscopic artificial lattice.

Abstract: A gaming device comprises a display, a processor, and a memory storing (a) reel strip data defining a set of reel strips, each reel of the set of reel strips comprising prize value symbols and non-prize value symbols, wherein at least one reel strip of the set of reel strips comprises a designated symbol and (b) instructions.

Abstract: A system for predicting and summarizing medical events from electronic health records includes a computer memory storing aggregated electronic health records from a multitude of patients of diverse age, health conditions, and demographics including medications, laboratory values, diagnoses, vital signs, and medical notes. The aggregated electronic health records are converted into a single standardized data structure format and ordered arrangement per patient, e.g., into a chronological order. A computer (or computer system) executes one or more deep learning models trained on the aggregated health records to predict one or more future clinical events and summarize pertinent past medical events related to the predicted events on an input electronic health record of a patient having the standardized data structure format and ordered into a chronological order.